{"id":"intra-amniotic-injection-of-digoxin","safety":{"commonSideEffects":[{"rate":null,"effect":"Maternal digoxin toxicity"},{"rate":null,"effect":"Fetal bradycardia"},{"rate":null,"effect":"Amniotic fluid infection/chorioamnionitis"},{"rate":null,"effect":"Premature rupture of membranes"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Digoxin is a cardiac glycoside that inhibits the Na+/K+-ATPase pump, increasing intracellular calcium and enhancing myocardial contractility while also slowing AV nodal conduction. When injected into amniotic fluid, digoxin diffuses across fetal membranes to reach fetal circulation, allowing direct treatment of fetal arrhythmias without systemic maternal administration. This route may provide higher fetal concentrations while potentially reducing maternal side effects.","oneSentence":"Intra-amniotic digoxin administration aims to treat fetal cardiac arrhythmias by crossing fetal membranes and exerting direct cardiac glycoside effects on fetal myocardium.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:16:39.867Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Fetal supraventricular tachycardia"},{"name":"Fetal atrial flutter"}]},"trialDetails":[{"nctId":"NCT01951079","phase":"PHASE3","title":"Intra Amniotic Injection of DIGOXIN for Feticide in Second Trimester Termination of Pregnancy","status":"UNKNOWN","sponsor":"Meir Medical Center","startDate":"2013-11","conditions":"Arrhythmia, ECG Changes, Hypotension","enrollment":100},{"nctId":"NCT01047748","phase":"NA","title":"A Trial of Digoxin Before Second-Trimester Abortion","status":"COMPLETED","sponsor":"White, Katharine O'Connell, M.D., M.P.H.","startDate":"2011-01","conditions":"Induced Abortion","enrollment":272}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":12,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Intra-amniotic injection of DIGOXIN","genericName":"Intra-amniotic injection of DIGOXIN","companyName":"Meir Medical Center","companyId":"meir-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Intra-amniotic digoxin administration aims to treat fetal cardiac arrhythmias by crossing fetal membranes and exerting direct cardiac glycoside effects on fetal myocardium. Used for Fetal supraventricular tachycardia, Fetal atrial flutter.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}