{"id":"intercostal-nerve-block","safety":{"commonSideEffects":[{"rate":null,"effect":"Pneumothorax"},{"rate":null,"effect":"Local anesthetic toxicity"},{"rate":null,"effect":"Bleeding/hematoma"},{"rate":null,"effect":"Nerve injury"}]},"_chembl":{"chemblId":"CHEMBL4297796","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This procedure involves injecting local anesthetic around the intercostal nerves that run along the ribs, temporarily interrupting pain signals from the chest wall and rib cage. It is used to provide analgesia for thoracic and upper abdominal surgical procedures, rib fractures, and post-operative pain management. The block can be administered as a single injection or continuous infusion via catheter.","oneSentence":"An intercostal nerve block is a regional anesthesia technique that delivers local anesthetic to the intercostal nerves to block pain sensation in the chest wall.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:16:24.555Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Post-operative pain management following thoracic surgery"},{"name":"Rib fracture pain management"},{"name":"Acute chest wall pain"}]},"trialDetails":[{"nctId":"NCT07498946","phase":"NA","title":"Comparison of Paravertebral Block and Deep Parasternal Intercostal Plane Block in Cardiac Surgery","status":"NOT_YET_RECRUITING","sponsor":"Gaziantep City Hospital","startDate":"2026-04-18","conditions":"Postoperative Pain, Cardiac Surgery, Postoperative Pain After Cardiac Surgery Via Median Sternotomy","enrollment":80},{"nctId":"NCT07493473","phase":"NA","title":"Parascapular Sub 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Cryoneurolysis to Treat Pain Following Thoracic Trauma","status":"ENROLLING_BY_INVITATION","sponsor":"University of California, San Diego","startDate":"2023-10-30","conditions":"Rib Fracture, Rib Fracture Multiple","enrollment":120},{"nctId":"NCT05642026","phase":"PHASE4","title":"INTERCOSTAL NERVE BLOCK: Efficacy of CINB for Patients With Multiple Rib Fractures","status":"RECRUITING","sponsor":"Zachary Warriner","startDate":"2025-09-23","conditions":"Rib Fractures","enrollment":180},{"nctId":"NCT05171179","phase":"PHASE3","title":"The Use of Pecs Blocks in Combination With Exparel in Breast Reconstruction Surgery","status":"COMPLETED","sponsor":"Northwestern University","startDate":"2021-10-22","conditions":"Mammaplasty","enrollment":60},{"nctId":"NCT07163026","phase":"NA","title":"Comparison of Two Plane Blocks Used in Open Ventral Hernia Repair Operations","status":"NOT_YET_RECRUITING","sponsor":"Ankara Ataturk Sanatorium Training and Research Hospital","startDate":"2025-09-30","conditions":"Ventral Hernia, Postoperative Pain, Postoperative Nausea","enrollment":50},{"nctId":"NCT05865327","phase":"NA","title":"UltrasouNd-guided Percutaneous Intercostal Nerve Cryoneurolysis for Analgesia Following Traumatic Rib Fracture","status":"RECRUITING","sponsor":"Sunnybrook Health Sciences Centre","startDate":"2023-10-23","conditions":"Rib Fractures, Rib Fracture Multiple, Rib; Fracture, With Flail Chest","enrollment":24},{"nctId":"NCT06833697","phase":"NA","title":"A Comparative Study of Erector Spinae Plane Block and Serratus Posterior Superior Intercostal Plane Block on Postoperative Opioid Consumption Following Breast and Axillary Dissection Surgery","status":"COMPLETED","sponsor":"Medipol University","startDate":"2025-01-27","conditions":"Breast Surgery, Erector Spinae Plane Block, Serratus Posterior Superior Intercostal Plane Block","enrollment":60},{"nctId":"NCT06983249","phase":"NA","title":"Rhomboid Intercostal and Subserratus Plane Block Versus Quadratus Lumborum Block in Management of Postoperative Pain After Open Nephrectomy","status":"ACTIVE_NOT_RECRUITING","sponsor":"Ain Shams University","startDate":"2025-07-01","conditions":"Open Nephrectomy Surgery","enrollment":50},{"nctId":"NCT07134660","phase":"NA","title":"Thoracic Surgery Intercostal Block Trial With Liposomal vs. Hydrochloride Bupivacaine","status":"NOT_YET_RECRUITING","sponsor":"Shanghai Pulmonary Hospital, Shanghai, China","startDate":"2025-09-01","conditions":"Postoperative Pain, Acute, Lung Cancer","enrollment":210},{"nctId":"NCT04990713","phase":"NA","title":"QoR40 Between Intercostal Block and Intercostal Block and Serratus Plane Catheter During VATS","status":"RECRUITING","sponsor":"London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's","startDate":"2022-06-30","conditions":"Video Assisted Thoracic Surgery (VATS), Pain Management","enrollment":200},{"nctId":"NCT06838039","phase":"NA","title":"Assessing the Impact of Additional Serratus Anterior Block Within 24-Hour on Postoperative Pain After Rhomboid Intercostal Block in VATS Patients","status":"RECRUITING","sponsor":"Al-Quds University","startDate":"2025-04-01","conditions":"Post Operative Pain, VATS","enrollment":50},{"nctId":"NCT06384664","phase":"NA","title":"Cryoablation Effects on Acute and Chronic Pain After Thoracotomy and Thoracoscopy","status":"RECRUITING","sponsor":"University of Michigan","startDate":"2024-06-03","conditions":"Pain, Postoperative, Intrathoracic Procedure","enrollment":80},{"nctId":"NCT07102173","phase":"NA","title":"Comparison of Loco-regional Analgesic Techniques in Patients Undergoing Video Assisted Thoracoscopic Surgery (VATS)","status":"NOT_YET_RECRUITING","sponsor":"ASST Sette Laghi","startDate":"2025-08-01","conditions":"Loco-regional Anesthesia","enrollment":72},{"nctId":"NCT05993273","phase":"NA","title":"Pain Control After VATS Anatomical Pulmonary Resections","status":"COMPLETED","sponsor":"University Hospital Padova","startDate":"2023-04-05","conditions":"Lung Cancer, Pain, Postoperative, Thoracic Neoplasms","enrollment":75},{"nctId":"NCT05906134","phase":"PHASE1, PHASE2","title":"Minimally Invasive Esophagectomy Pain Control Trial","status":"RECRUITING","sponsor":"Swedish Medical Center","startDate":"2022-04-26","conditions":"Postoperative Pain, Acute, Postoperative Complications","enrollment":30},{"nctId":"NCT07079436","phase":"NA","title":"EIT Evaluation of Pulmonary Ventilation With Different Ropivacaine Concentrations in Intercostal Nerve Blockade","status":"NOT_YET_RECRUITING","sponsor":"Fudan University","startDate":"2025-08-10","conditions":"Intercostal Nerve Block, Pulmonary Ventilation, Anesthesia, Local","enrollment":72},{"nctId":"NCT06225895","phase":"NA","title":"Bilateral Rhomboid Intercostal Block for Perioperative Analgesia in Patients Undergoing Bilateral Reduction Mammoplasty","status":"COMPLETED","sponsor":"Zagazig University","startDate":"2024-02-01","conditions":"Analgesia","enrollment":72},{"nctId":"NCT04985500","phase":"EARLY_PHASE1","title":"ESP/PIF for Sternotomy","status":"ACTIVE_NOT_RECRUITING","sponsor":"Icahn School of Medicine at Mount Sinai","startDate":"2021-07-09","conditions":"Cardiac Surgery, Sternotomy","enrollment":225},{"nctId":"NCT07061262","phase":"NA","title":"External Oblique Plane Block and Subcostal Tap Block for Laparoscopic Cholecystectomy","status":"COMPLETED","sponsor":"Haseki Training and Research Hospital","startDate":"2024-01-01","conditions":"Peripheral Nerve Block, Cholecystectomy, Laparoscopic, Pain After Surgery","enrollment":90},{"nctId":"NCT07053397","phase":"NA","title":"We Have Two Groups. Both Groups Received a Deep Serratus Anterior Plane Block. One Group Had a Catheter for Continuous Infusion, While the Other Received IV Analgesics Postoperatively. Analgesic Effects Between the Two Groups Were Compared","status":"COMPLETED","sponsor":"Istanbul Medeniyet University","startDate":"2025-01-26","conditions":"Pain Management After Surgery, Regional Anaesthesia","enrollment":50},{"nctId":"NCT06392191","phase":"NA","title":"Comparison of Bupivacaine Liposomal vs Bupivacaine Combined With Dexamethasone for Postoperative Pain in VATS","status":"COMPLETED","sponsor":"Affiliated Hospital of Jiaxing University","startDate":"2024-11-10","conditions":"Thoracic Surgery","enrollment":148},{"nctId":"NCT07021651","phase":"NA","title":"COMPARISON OF ERECTOR SPINA PLAN BLOCK AND THORACIC PARAVERTEBRAL BLOCK FOR PERIOPERATIVE ANALGESIA","status":"NOT_YET_RECRUITING","sponsor":"Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital","startDate":"2025-07-10","conditions":"Paravertebral Block","enrollment":60},{"nctId":"NCT07003698","phase":"NA","title":"Postoperative Analgesic Efficacy of Recto Intercostal Nerve Block","status":"NOT_YET_RECRUITING","sponsor":"Ankara Etlik City Hospital","startDate":"2025-06-22","conditions":"Laparoskopic Cholecystectomy, Recto Intercostal Nerve Block","enrollment":60},{"nctId":"NCT07002541","phase":"NA","title":"PECS-II vs ESP in Nociception Level Index Guided Breast Surgery","status":"RECRUITING","sponsor":"Koç University","startDate":"2024-12-01","conditions":"Intraoperative Pain, Postoperative Pain","enrollment":90},{"nctId":"NCT04864210","phase":"PHASE2","title":"Video-assisted Thoracoscopic Surgery - Exparel Study","status":"COMPLETED","sponsor":"Nada Sadek","startDate":"2021-02-02","conditions":"Pain, Postoperative","enrollment":176},{"nctId":"NCT06810375","phase":"PHASE3","title":"Erector Spinae Versus Intercostal Nerve Blocks With Liposomal Bupivacaine for Analgesia in Thoracic Surgery","status":"RECRUITING","sponsor":"George Washington University","startDate":"2025-03-01","conditions":"Lung 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