{"id":"intensive-treatment-with-sodium-bicarbonate","safety":{"commonSideEffects":[{"rate":null,"effect":"Metabolic alkalosis"},{"rate":null,"effect":"Hypernatremia"},{"rate":null,"effect":"Hypokalemia"},{"rate":null,"effect":"Nausea"}]},"_chembl":{"chemblId":"CHEMBL1353","moleculeType":"Small molecule","molecularWeight":"84.01"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Intensive sodium bicarbonate treatment works by systemic alkalinization, which counteracts the acidic microenvironment typical of solid tumors. The alkaline pH is hypothesized to reduce tumor cell proliferation, enhance drug penetration, and improve oxygenation. This approach is based on the observation that cancer cells thrive in acidic conditions and may be suppressed by pH normalization.","oneSentence":"Sodium bicarbonate raises blood and tissue pH to create an alkaline environment that may inhibit tumor growth and enhance chemotherapy efficacy.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:49:25.615Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Solid tumors (investigational approach to enhance chemotherapy and reduce tumor acidosis)"}]},"trialDetails":[{"nctId":"NCT07451561","phase":"NA","title":"Role of Combination Therapy of Glucose Insulin Potassium Infusion (GIK), Intravenous Hydrocortisone and Oral Sevelamer in Treatment of Acute Aluminum Phosphide Poisoned Cases Admitted to Intensive Care Unit (ICU) at Sohag University Hospitals.","status":"NOT_YET_RECRUITING","sponsor":"Sohag University","startDate":"2026-03","conditions":"Acute Aluminum Phosphide Poisoned Cases","enrollment":74},{"nctId":"NCT03399331","phase":"PHASE1","title":"Honey or Olive Oil for Treating Oral Mucositis in Children and Adults With Leukemia Receiving Intensive Chemotherapy","status":"COMPLETED","sponsor":"American University of Beirut Medical Center","startDate":"2017-07-10","conditions":"Oral Mucositis, Leukemia","enrollment":45},{"nctId":"NCT01491243","phase":"PHASE4","title":"N-GAL Allows Intensive Treatment of Contrast Induced Nephropathy","status":"UNKNOWN","sponsor":"University of Roma La Sapienza","startDate":"2014-01","conditions":"Coronary Artery Disease","enrollment":100}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":412,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Intensive treatment with sodium bicarbonate","genericName":"Intensive treatment with sodium bicarbonate","companyName":"University of Roma La Sapienza","companyId":"university-of-roma-la-sapienza","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Sodium bicarbonate raises blood and tissue pH to create an alkaline environment that may inhibit tumor growth and enhance chemotherapy efficacy. Used for Solid tumors (investigational approach to enhance chemotherapy and reduce tumor acidosis).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}