{"id":"intensive-bp-control","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Syncope"},{"rate":null,"effect":"Acute kidney injury"},{"rate":null,"effect":"Hyperkalemia"},{"rate":null,"effect":"Fatigue"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Intensive BP control typically involves the use of multiple antihypertensive agents (such as ACE inhibitors, ARBs, calcium channel blockers, and/or diuretics) to achieve lower blood pressure targets than standard care. This approach aims to reduce the risk of stroke, myocardial infarction, heart failure, and chronic kidney disease by maintaining stricter BP targets, often <120 mmHg systolic in high-risk populations.","oneSentence":"Intensive blood pressure control reduces cardiovascular and cerebrovascular morbidity and mortality through aggressive pharmacological management of hypertension.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:49:26.576Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertension management for cardiovascular risk reduction"},{"name":"Prevention of stroke and myocardial infarction in high-risk patients"}]},"trialDetails":[{"nctId":"NCT04040634","phase":"NA","title":"Optimal Blood Pressure for the prevenTIon of Major vAscuLar Events in Patients With DIABETES Mellitus (OPTIMAL-DIABETES)","status":"ACTIVE_NOT_RECRUITING","sponsor":"Hospital Israelita Albert Einstein","startDate":"2019-08-08","conditions":"Diabetes Mellitus, High 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