{"id":"insulin-asp-b28","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypoglycemia"},{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Weight gain"},{"rate":null,"effect":"Lipodystrophy"}]},"_chembl":{"chemblId":"CHEMBL1201631","moleculeType":"Protein"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This insulin analog has aspartic acid substituted at position B28 of the insulin B-chain, which modifies its pharmacokinetic properties compared to human insulin. It acts as an exogenous insulin replacement therapy, mimicking the body's natural insulin response by facilitating cellular glucose uptake, promoting glycogen synthesis, and inhibiting gluconeogenesis. The structural modification allows for faster absorption and onset of action compared to regular human insulin.","oneSentence":"Insulin Asp(B28) is a rapid-acting insulin analog that binds to insulin receptors on cells to promote glucose uptake and utilization for energy and storage.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:49:08.360Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Type 1 diabetes mellitus"},{"name":"Type 2 diabetes mellitus"}]},"trialDetails":[],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":8,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["NovoRapid","NovoRapid insulin","Aspart insulin","Novolog"],"phase":"marketed","status":"active","brandName":"Insulin, Asp(B28)-","genericName":"Insulin, Asp(B28)-","companyName":"Oxford University Hospitals NHS Trust","companyId":"oxford-university-hospitals-nhs-trust","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Insulin Asp(B28) is a rapid-acting insulin analog that binds to insulin receptors on cells to promote glucose uptake and utilization for energy and storage. Used for Type 1 diabetes mellitus, Type 2 diabetes mellitus.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}