{"id":"insulin-actrapid","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypoglycemia"},{"rate":null,"effect":"Weight gain"},{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Lipodystrophy"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Actrapid is a soluble (regular) human insulin formulation that mimics the body's natural insulin secretion in response to meals. It binds to insulin receptors on muscle, fat, and liver cells, facilitating glucose transport into cells and promoting glycogen synthesis while inhibiting gluconeogenesis. This rapid-acting formulation is typically used in combination with longer-acting insulins or as a bolus therapy with meals.","oneSentence":"Insulin Actrapid is a rapid-acting insulin that binds to insulin receptors on cells to promote glucose uptake and utilization, lowering blood glucose levels.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:49:10.754Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Type 1 diabetes mellitus"},{"name":"Type 2 diabetes mellitus"}]},"trialDetails":[{"nctId":"NCT02230137","phase":"NA","title":"Text Message for Adolescents With Poorly Controlled Type 1 Diabetes","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2015-02","conditions":"Type 1 Diabetes","enrollment":92},{"nctId":"NCT02728635","phase":"NA","title":"Epigenetic Regulation of Human Adipose Tissue Distribution","status":"ACTIVE_NOT_RECRUITING","sponsor":"AdventHealth Translational Research Institute","startDate":"2016-07","conditions":"Obesity","enrollment":27},{"nctId":"NCT07494084","phase":"PHASE4","title":"Sleep Loss and Circadian Misalignment - Mechanisms of Insulin Resistance","status":"NOT_YET_RECRUITING","sponsor":"Washington State University","startDate":"2026-05-01","conditions":"Shift Work Schedule, Circadian Rhythm, Insulin Resistance","enrollment":24},{"nctId":"NCT05713799","phase":"PHASE2","title":"Trial of the Combination of Alpha-Lipoic Acid and Mirabegron in Women and in Men With Obesity","status":"NOT_YET_RECRUITING","sponsor":"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","startDate":"2026-04-01","conditions":"Insulin Resistance, Obesity","enrollment":60},{"nctId":"NCT07494474","phase":"","title":"Risk Assessment of Pancreatic Islet Autoimmunity in Patients With AITD","status":"NOT_YET_RECRUITING","sponsor":"Nanjing Medical University","startDate":"2026-08-31","conditions":"Autoimmune Thyroid Disease","enrollment":834},{"nctId":"NCT06602141","phase":"NA","title":"Assessments of Adipogenesis, Lipid Turnover and Cellular Composition in Adipose Tissue in Response to Endurance Exercise","status":"RECRUITING","sponsor":"AdventHealth Translational Research Institute","startDate":"2024-09-11","conditions":"Obesity","enrollment":70},{"nctId":"NCT07496320","phase":"NA","title":"Critical Food Ingredients on Immunocompetence to Prevent the Risk and Development of Obesity/Metabolic Syndrome","status":"COMPLETED","sponsor":"IMDEA Food","startDate":"2024-10-23","conditions":"Immunological Status, Healthy Volunteers, Healthy Volunteers - Male and Female","enrollment":60},{"nctId":"NCT05933499","phase":"PHASE2","title":"Effect of Tirzepatide and Bimagrumab on Body Composition, Insulin Sensitivity, and Bone in Adults With Obesity","status":"RECRUITING","sponsor":"Massachusetts General Hospital","startDate":"2025-11-05","conditions":"Obesity","enrollment":63},{"nctId":"NCT02346838","phase":"NA","title":"Prebiotics, Gut Microbiota, and Cardiometabolic Health","status":"COMPLETED","sponsor":"Virginia Polytechnic Institute and State University","startDate":"2014-01","conditions":"Prediabetes","enrollment":22},{"nctId":"NCT07293715","phase":"PHASE4","title":"Permissive Versus Strict Intrapartum Glucose Management in Type 1 Diabetes (PRISM-T1D)","status":"RECRUITING","sponsor":"Ohio State University","startDate":"2026-02-25","conditions":"Pregnancy, High Risk, Type 1 Diabetes","enrollment":44},{"nctId":"NCT02556840","phase":"NA","title":"Impact on Birth Weight of Two Therapeutic Strategies (Insulin Therapy From the Beginning of Pregnancy vs. Insulin Therapy Initiated According to Fetal Growth Evaluated by Ultrasonography Measurements) in Pregnant Women With Monogenic Diabetes","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2016-04-25","conditions":"Maturity-Onset Diabetes of the Young","enrollment":46},{"nctId":"NCT07037420","phase":"PHASE2","title":"ALXN2420 Versus Placebo in Combination With Somatostatin Analogs in Participants With Acromegaly","status":"RECRUITING","sponsor":"Alexion Pharmaceuticals, Inc.","startDate":"2025-10-28","conditions":"Acromegaly","enrollment":60},{"nctId":"NCT07495956","phase":"PHASE1, PHASE2","title":"cfMSC Therapy for Diabetes","status":"RECRUITING","sponsor":"Shenzhen Geno-Immune Medical Institute","startDate":"2026-03-16","conditions":"Type II Diabetes Mellitus","enrollment":30},{"nctId":"NCT07361874","phase":"NA","title":"IMPACT-MACS: Adrenalectomy vs Semaglutide for Metabolic Outcomes in Mild Autonomous Cortisol Secretion","status":"RECRUITING","sponsor":"University of Texas Southwestern Medical Center","startDate":"2026-03-05","conditions":"Mild Autonomous Cortisol Secretion (MACS), Autonomous Cortisol Secretion (ACS), Subclinical Cushing's","enrollment":75},{"nctId":"NCT05062785","phase":"PHASE1","title":"Dose-Finding Study of Intranasal Insulin in Healthy Participants Insulin in Healthy Participants","status":"COMPLETED","sponsor":"Robert Silbergleit","startDate":"2021-10-04","conditions":"Out-Of-Hospital Cardiac Arrest, Healthy","enrollment":24},{"nctId":"NCT06274749","phase":"NA","title":"Effects of Urolithin A Supplementation on Glucose Metabolism in Healthy Adults 55 >= Years Old: A Randomized Triple-Masked Controlled Clinical Trial","status":"RECRUITING","sponsor":"National Institute on Aging (NIA)","startDate":"2026-04-01","conditions":"Healthy Volunteer","enrollment":180},{"nctId":"NCT07446998","phase":"PHASE2","title":"Proof-of-Concept Study Evaluating Total Body Weight, Physical Function & Safety of Enobosarm in Patients Treated With GLP-1 Receptor Agonist, for Weight Loss","status":"RECRUITING","sponsor":"Veru Inc.","startDate":"2026-03","conditions":"Obesity & Overweight, Mobility Disability, HOMA-IR","enrollment":200},{"nctId":"NCT07496619","phase":"NA","title":"Effects of Diabetic Educational Intervention and Dietary Supplements on Blood Glucose, Lipid Profile Levels, Body Mass Index, and Pain Management Among Adult Individuals With Painful Diabetic Peripheral Neuropathy.","status":"COMPLETED","sponsor":"Al-Quds University","startDate":"2022-03-01","conditions":"Pain, Glucose Levels, Low-density Lipoprotein Lipid Composition","enrollment":62},{"nctId":"NCT06867198","phase":"NA","title":"Peanuts for Cardiometabolic, Brain, and Intestinal Health","status":"RECRUITING","sponsor":"Georgia State University","startDate":"2025-03-06","conditions":"Prediabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Cognition","enrollment":72},{"nctId":"NCT07284316","phase":"PHASE2, PHASE3","title":"Effect of a Multidomain Intervention Plus Turmeric on the Prevention of Cognitive Decline in People Over 55 Years of Age With Insulin Resistance.","status":"ACTIVE_NOT_RECRUITING","sponsor":"Instituto Mexicano del Seguro Social","startDate":"2025-02-20","conditions":"Cognitive Decline, Subjective Cognitive Impairment, Insulin Resistance","enrollment":100},{"nctId":"NCT07004504","phase":"","title":"MEnstrual Cycle pHase ANd dIabeteS Management","status":"COMPLETED","sponsor":"DCB Research AG","startDate":"2023-12-14","conditions":"Type 1 Diabetes Mellitus","enrollment":77},{"nctId":"NCT07492992","phase":"","title":"HOME-AHCL: Home-Based Implementation of an Advanced Hybrid Closed-Loop System With Telemonitoring in Type 1 Diabetes","status":"NOT_YET_RECRUITING","sponsor":"Air Liquide Healthcare Spain","startDate":"2026-04","conditions":"Diabetes Mellitus Type 1","enrollment":25},{"nctId":"NCT06735651","phase":"NA","title":"Wild Blueberries for Gut, Brain, and Cardiometabolic Health in Prediabetes","status":"RECRUITING","sponsor":"Georgia State University","startDate":"2024-09-20","conditions":"Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Female, Adult","enrollment":30},{"nctId":"NCT06948760","phase":"NA","title":"Testing a Conversion Factor for a More Rapidly Acting Insulin in an Automated Insulin Delivery System Among Adolescents With T1D","status":"COMPLETED","sponsor":"Mark D. DeBoer, MD, MSc., MCR","startDate":"2025-07-23","conditions":"Type 1 Diabetes","enrollment":11},{"nctId":"NCT02298725","phase":"NA","title":"Individual Metabolism and Physiology Signature Study","status":"COMPLETED","sponsor":"USDA, Western Human Nutrition Research Center","startDate":"2014-12-16","conditions":"Insulin Resistance, Metabolic Syndrome X, Obesity","enrollment":52},{"nctId":"NCT07491133","phase":"NA","title":"Effect of Ambient Temperature on Blood Glucose and Insulin Absorption in Adults With Type 1 Diabetes","status":"NOT_YET_RECRUITING","sponsor":"Institut de Recherches Cliniques de Montreal","startDate":"2026-03","conditions":"Type 1 Diabetes Mellitus","enrollment":30},{"nctId":"NCT07490964","phase":"","title":"Polycystic Ovary Syndrome in Type 1 Diabetes","status":"NOT_YET_RECRUITING","sponsor":"Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal","startDate":"2026-04-01","conditions":"Type 1 Diabetes Mellitus, Polycystic Ovary Syndrome (PCOS)","enrollment":60},{"nctId":"NCT04128995","phase":"PHASE4","title":"Surgical or Medical Treatment","status":"ACTIVE_NOT_RECRUITING","sponsor":"Children's Hospital Medical Center, Cincinnati","startDate":"2019-12-15","conditions":"Diabetes Mellitus, Type 2, Pediatric Obesity, Bariatric Surgery Candidate","enrollment":88},{"nctId":"NCT00445627","phase":"","title":"Effect of Short-Term Beta-Cell Rest in Adolescents and Young Adults With Type 2 Diabetes Mellitus","status":"COMPLETED","sponsor":"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","startDate":"2007-06-18","conditions":"Obesity, Overweight, Diabetes Mellitus, Type 2","enrollment":82},{"nctId":"NCT06362265","phase":"PHASE1","title":"A Study to Evaluate Pharmacokinetics of LY3209590 in Pediatric Participants With Type 2 Diabetes Mellitus","status":"COMPLETED","sponsor":"Eli Lilly and Company","startDate":"2024-10-10","conditions":"Type 2 Diabetes Mellitus","enrollment":15},{"nctId":"NCT00001987","phase":"","title":"Genetic Studies of Insulin and Diabetes","status":"RECRUITING","sponsor":"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","startDate":"1976-02-01","conditions":"Diabetes Mellitus, Severe Insulin Resistance","enrollment":1200},{"nctId":"NCT00862433","phase":"PHASE1","title":"Vitamin E Pharmacokinetics and Biomarkers in Normal and Obese Women","status":"COMPLETED","sponsor":"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","startDate":"2014-10-10","conditions":"Diabetes, Fatty Liver, Obesity","enrollment":50},{"nctId":"NCT03527537","phase":"PHASE4","title":"Gestational Diabetes and Pharmacotherapy (GAP)","status":"ACTIVE_NOT_RECRUITING","sponsor":"Medical College of Wisconsin","startDate":"2021-05-04","conditions":"Gestational Diabetes","enrollment":416},{"nctId":"NCT07487623","phase":"NA","title":"Evaluation of the Hepatoprotective Effects of a Nutritional Supplement in Patients With Liver Disease Secondary to Chronic Hepatitis C Virus Infection (RESQUETI Study).","status":"RECRUITING","sponsor":"University of Guadalajara","startDate":"2025-10-11","conditions":"Liver Disease Chronic, HEPATITIS C VIRUS CHRONIC INFECTION","enrollment":26},{"nctId":"NCT01234727","phase":"","title":"Comparison Study of Blood Glucose Monitoring Systems in People With Diabetes","status":"COMPLETED","sponsor":"Abbott Diabetes Care","startDate":"2010-12","conditions":"Diabetes Mellitus","enrollment":501},{"nctId":"NCT06739811","phase":"NA","title":"Clinical Evaluation of the Medtronic Implantable Insulin Pump System (MIIPS 2020) in Adult Subjects With Type 1 Diabetes (CIP347)","status":"RECRUITING","sponsor":"Medtronic Diabetes","startDate":"2025-03-21","conditions":"Type I Diabetes","enrollment":40},{"nctId":"NCT05610800","phase":"PHASE2","title":"Exenatide for Smoking Cessation and Prevention of Weight Gain","status":"COMPLETED","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2022-12-07","conditions":"Smoking Cessation, Weight Gain","enrollment":140},{"nctId":"NCT04542148","phase":"PHASE2","title":"Glycemic Control After Antenatal Corticosteroids in Women With Pregestational and Gestational Diabetes","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Alabama at Birmingham","startDate":"2022-02-10","conditions":"Diabetes Mellitus, Type 2, Preterm Birth, Pregnancy, High Risk","enrollment":120},{"nctId":"NCT07278063","phase":"NA","title":"Impact of Dietary Fat and Menstrual Cycle Phases in Type 1 Diabetes","status":"NOT_YET_RECRUITING","sponsor":"Instituto de Investigacion Sanitaria La Fe","startDate":"2026-05","conditions":"Type 1 Diabetes Mellitus, Glycemic Variability, Sex Characteristics","enrollment":50},{"nctId":"NCT07224321","phase":"PHASE2","title":"INHALE-1st: Afrezza® For Youth With Newly-Diagnosed Type 1 Diabetes","status":"RECRUITING","sponsor":"Mannkind Corporation","startDate":"2026-02","conditions":"Type 1 Diabetes Mellitus","enrollment":100},{"nctId":"NCT07384052","phase":"PHASE1","title":"Safety and Feasibility of Intranasal Insulin in Patients With Spinal Cord Injury","status":"RECRUITING","sponsor":"HealthPartners Institute","startDate":"2026-02-20","conditions":"Spinal Cord Injury","enrollment":12},{"nctId":"NCT04791371","phase":"NA","title":"Role of Microvascular Insulin Resistance and Cardiorespiratory Fitness Diabetes","status":"RECRUITING","sponsor":"University of Colorado, Denver","startDate":"2022-06-17","conditions":"Type 2 Diabetes, Overweight and Obesity","enrollment":150},{"nctId":"NCT07460336","phase":"NA","title":"Effects of Cofrogliptin on Beta-Cell Function in LADA Patients","status":"NOT_YET_RECRUITING","sponsor":"Second Xiangya Hospital of Central South University","startDate":"2026-03-15","conditions":"Latent Autoimmune Diabetes in Adults (LADA)","enrollment":84},{"nctId":"NCT01517100","phase":"PHASE1","title":"The Role of Endocannabinoids in Insulin Production and Action","status":"COMPLETED","sponsor":"National Institute on Aging (NIA)","startDate":"2012-01-05","conditions":"Healthy Volunteers","enrollment":45},{"nctId":"NCT07486557","phase":"NA","title":"Cistanche Deserticola Extract Combined With Aerobic Exercise Improves Body Composition, Insulin Resistance and Inflammation in Men With Central Obesity","status":"COMPLETED","sponsor":"Beijing Sport University","startDate":"2025-06-01","conditions":"Central Obesity, Insulin Resistance, Inflammation","enrollment":125},{"nctId":"NCT07485101","phase":"NA","title":"Glycemic Targets During CPB in Elderly Diabetes","status":"NOT_YET_RECRUITING","sponsor":"Beijing Anzhen Hospital","startDate":"2026-04-01","conditions":"Glycemic Management During CPB in Elderly Diabetic Cardiac Surgery","enrollment":3000},{"nctId":"NCT06801769","phase":"NA","title":"Study for the Identification of a Score to Assess Intrapancreatic Fat Through Eco-Elastography and Its Correlation With Metabolic Syndrome and Insulin-Secreting Cells.","status":"RECRUITING","sponsor":"Catholic University of the Sacred Heart","startDate":"2025-03-17","conditions":"Pancreatic Steatosis, Metabolic Syndrome X, Diabetes Mellitus","enrollment":100},{"nctId":"NCT06503809","phase":"NA","title":"Efficacy and Safety of a Ketogenic Diet in Type 1 Diabetes","status":"RECRUITING","sponsor":"Washington University School of Medicine","startDate":"2024-08-12","conditions":"Diabetes Mellitus, Type 1","enrollment":58},{"nctId":"NCT05663515","phase":"","title":"A Pan-European Post-Authorisation Safety Study: Risk of Pancreatic Cancer Among Type 2 Diabetes Patients Who Initiated Exenatide as Compared With Those Who Initiated Other Non-Glucagon-Like Peptide 1 Receptor Agonists Based Glucose Lowering Drugs","status":"RECRUITING","sponsor":"AstraZeneca","startDate":"2024-09-30","conditions":"Pancreatic Cancer","enrollment":24000},{"nctId":"NCT07483723","phase":"NA","title":"Glucose Profiles in Women With Polycystic Ovary Syndrome","status":"RECRUITING","sponsor":"Centre Hospitalier Universitaire, Amiens","startDate":"2026-01-06","conditions":"Polycystic Ovary Syndrome, Glucose Profile, Insulin Resistance","enrollment":80},{"nctId":"NCT07480993","phase":"","title":"Serum Betatrophin Levels in Normal-Weight and Overweight Adolescents With PCOS","status":"COMPLETED","sponsor":"Ankara City Hospital Bilkent","startDate":"2026-01-15","conditions":"Polycystic Ovary Syndrome (PCOS), Betatrophin, Body Mass Index (BMI)","enrollment":90},{"nctId":"NCT06793085","phase":"","title":"Pro- and Anti-inflammatory Cytokines in PCOS","status":"RECRUITING","sponsor":"Jagiellonian University","startDate":"2025-01-20","conditions":"Reproductive Age, PCOS (Polycystic Ovary Syndrome)","enrollment":100},{"nctId":"NCT06793072","phase":"","title":"Adipokines in Polycystic Ovary Syndrome","status":"RECRUITING","sponsor":"Jagiellonian University","startDate":"2025-01-20","conditions":"PCOS, Reproductive Age","enrollment":300},{"nctId":"NCT07481500","phase":"NA","title":"Speculum-Free Intravitreal Injection Using Cotton-Tipped Applicator Retraction: A Randomized Trial of Pain, Procedure Time, Patient Satisfaction, and Safety","status":"NOT_YET_RECRUITING","sponsor":"Jakkrit Juhong","startDate":"2026-06","conditions":"Neovascular Age-Related Macular Degeneration (nAMD), Diabetic Macular Edema, Retinal Vein Occlusion","enrollment":120},{"nctId":"NCT04645693","phase":"","title":"The Impact of Oral Health in HIV Patients on Antiretroviral Therapy","status":"COMPLETED","sponsor":"University of Pennsylvania","startDate":"2021-02-24","conditions":"HIV, Periodontal Diseases, Caries","enrollment":227},{"nctId":"NCT06793098","phase":"","title":"Functional Proteins in Polycystic Ovary Syndrome","status":"RECRUITING","sponsor":"Jagiellonian University","startDate":"2025-01-20","conditions":"Reproductive Age, PCOS (Polycystic Ovary Syndrome)","enrollment":100},{"nctId":"NCT07479134","phase":"NA","title":"Production of Stem Cells for the Generation of Pancreatic Cells","status":"RECRUITING","sponsor":"Ospedale San Raffaele","startDate":"2026-03-01","conditions":"Diabetes","enrollment":100},{"nctId":"NCT07471854","phase":"NA","title":"Efficacy and Safety of Combined Nanofat Injection With Either Platelet Rich Fibrin or Microneedling Versus Nanofat Injection Alone in the Treatment of Facial Atrophic Post Acne Scars","status":"NOT_YET_RECRUITING","sponsor":"Assiut University","startDate":"2026-05-01","conditions":"Acne Scars - Atrophic","enrollment":42},{"nctId":"NCT07423637","phase":"NA","title":"The Impact of Early Automated Insulin Delivery (AID) Therapy on Diabetes Control and Comorbidities, and Cost-effectiveness of AID Treatment","status":"NOT_YET_RECRUITING","sponsor":"Helsinki University Central Hospital","startDate":"2026-04-01","conditions":"Type 1 Diabetes","enrollment":100},{"nctId":"NCT06671587","phase":"PHASE4","title":"iGlarLixi CGM Study in Chinese T2D Individuals After OADs","status":"RECRUITING","sponsor":"Sanofi","startDate":"2024-12-10","conditions":"Type 2 Diabetes (T2D)","enrollment":678},{"nctId":"NCT07470593","phase":"","title":"Study of Glucose Tolerance Abnormalities Using Continuous Glucose Monitoring for the Identification of Early Loss of Pancreatic Islet Graft Function.","status":"RECRUITING","sponsor":"University Hospital, Strasbourg, France","startDate":"2025-12-15","conditions":"Type 1 Diabetes (T1D)","enrollment":36},{"nctId":"NCT07120828","phase":"PHASE4","title":"The Role of CYP8B1 Polymorphisms in Modulating the Biochemical Pathways Affected by SGLT2 Inhibitors in T2DM and Obesity","status":"COMPLETED","sponsor":"Erbil Polytechnic University","startDate":"2025-07-15","conditions":"Type 2 Diabetes, Obese Diabetics, Obese Patients (BMI ≥ 30 kg/m²)","enrollment":260},{"nctId":"NCT06998238","phase":"NA","title":"Evaluating the Influence of Diet-induced Weight Loss on Fat (Adipose) Tissue's Insulin Sensitivity and Testosterone Synthesis in Women With Overweight or Obesity, Insulin Resistance, and Hyperandrogenemia","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Missouri-Columbia","startDate":"2024-01-07","conditions":"Overweight and Obesity, Hyperandrogenemia, Insulin Resistance","enrollment":8},{"nctId":"NCT07478211","phase":"","title":"Menstrual Cycle Mapping While Using Closed-Loop Insulin Delivery","status":"RECRUITING","sponsor":"Lia Bally","startDate":"2025-05-09","conditions":"Diabetes Mellitus, Type 1, Energy Metabolism","enrollment":40},{"nctId":"NCT06198725","phase":"NA","title":"Intervention for Children With Type 1 Diabetes Targeting Gut Microbes","status":"RECRUITING","sponsor":"Children's Hospital of Fudan University","startDate":"2024-01-08","conditions":"Type 1 Diabetes","enrollment":110},{"nctId":"NCT06551285","phase":"NA","title":"Study of the Effect of a Nutritional Supplement on Microbiota, Metabolic Control, Inflammatory Profile, and Quality of Life in Patients With Polycystic Ovary Syndrome.","status":"RECRUITING","sponsor":"Celia Bañuls","startDate":"2024-02-01","conditions":"Polycystic Ovary Syndrome, Metabolic Syndrome","enrollment":120},{"nctId":"NCT00340132","phase":"","title":"Cross-Sectional and Longitudinal Studies of \"Pre-Diabetes\" in the Pima Indians","status":"COMPLETED","sponsor":"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","startDate":"1983-01-01","conditions":"Weight Gain, Overweight, Insulin Resistance","enrollment":1759},{"nctId":"NCT07478497","phase":"NA","title":"30 Day Insulin Balance Metabolic Health Optimization Protocol","status":"RECRUITING","sponsor":"Efforia, Inc","startDate":"2025-10-21","conditions":"Insulin","enrollment":100},{"nctId":"NCT06748963","phase":"NA","title":"Fasted Exercise Training in Type 1 Diabetes (FED-T1D)","status":"RECRUITING","sponsor":"University of Alberta","startDate":"2025-01-01","conditions":"Diabetes Mellitus, Type 1","enrollment":20},{"nctId":"NCT07472179","phase":"NA","title":"Effect of Pioglitazone vs Metformin on Clinical, Biochemical and Hormonal Parameters of Insulin Resistant PCOS","status":"COMPLETED","sponsor":"Mst.Sumyara Khatun","startDate":"2024-08-12","conditions":"PCOS(Insulin Resistant)","enrollment":60},{"nctId":"NCT07472920","phase":"NA","title":"Empagliflozin Adjunctive Therapy in Bipolar Depression","status":"NOT_YET_RECRUITING","sponsor":"University of Sao Paulo","startDate":"2026-03-09","conditions":"Bipolar Disorder, Bipolar Depression, Insulin Resistance","enrollment":20},{"nctId":"NCT07212179","phase":"NA","title":"Safety and Feasibility of a Self-Learning Bolus Calculator With Simplified Meal Announcement in Adolescents With Type 1 Diabetes Using Automated Insulin Delivery","status":"RECRUITING","sponsor":"Anas El Fathi","startDate":"2026-03-03","conditions":"Type 1 Diabetes","enrollment":6},{"nctId":"NCT07466173","phase":"NA","title":"The Importance of Insulin Action in the Brain for the Immune System During Physical Activity-Overweight","status":"NOT_YET_RECRUITING","sponsor":"University of Ulm","startDate":"2026-04","conditions":"Insulin Sensitivity","enrollment":8},{"nctId":"NCT07475143","phase":"NA","title":"A Comparative Study Between Effect Of Mini-gastric Bypass and Single Anastmosis Sleeve Jujenal Bypass On Levels Of GLP-1, GIP, PYY, Insulin Resistance and Type II DM Resolution","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2024-02-01","conditions":"Incretin Hormones Plasma Levels, Gastric Bypass Surgery","enrollment":40},{"nctId":"NCT06688461","phase":"NA","title":"High Intensity Interval Training and Insulin Sensitivity in Type 2 Diabetes","status":"RECRUITING","sponsor":"Finis Terrae University","startDate":"2024-10-01","conditions":"Type 2 Diabetes, Lifestyle-related Condition, Insulin Sensitivity/Resistance","enrollment":36},{"nctId":"NCT05470504","phase":"PHASE2","title":"Study of Growth Hormone Inhibition Using Pegvisomant in Severe Insulin Resistance","status":"RECRUITING","sponsor":"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","startDate":"2023-01-23","conditions":"Insulin Receptor Mutation, Partial Lipodystrophy","enrollment":25},{"nctId":"NCT02176681","phase":"PHASE4","title":"A Prospective, Multicenter, Randomized, Open-label Study of 12 Week Duration to Evaluate the Effect of VILDagliptin Added to Insulin on Glycaemic Control in haemoDIALyzed Patients With Type 2 Diabetes: Probe Analysis of CGM","status":"COMPLETED","sponsor":"University Hospital, Strasbourg, France","startDate":"2014-06","conditions":"Haemodialyzed, Type 2 Diabetes","enrollment":70},{"nctId":"NCT07467161","phase":"","title":"Relationship Between Insulin Resistance and Vitamin D in Type 2 Diabetes Mellitus (DM)","status":"NOT_YET_RECRUITING","sponsor":"Assiut University","startDate":"2026-03","conditions":"Type 2 Diabetes","enrollment":165},{"nctId":"NCT05781711","phase":"PHASE2","title":"Clinical Study to Evaluate the Possible Efficacy of Metformin in Patients With Parkinson's Disease","status":"COMPLETED","sponsor":"Tanta University","startDate":"2023-01-06","conditions":"Parkinson Disease","enrollment":60},{"nctId":"NCT06762314","phase":"PHASE2","title":"Efficacy and Safety of Empagliflozin or Semaglutide in Overweight/Obese Patients With Type 1 Diabetes","status":"RECRUITING","sponsor":"Mostafa Bahaa","startDate":"2025-01-20","conditions":"Diabetes","enrollment":105},{"nctId":"NCT03878706","phase":"","title":"The Cardiovascular Effect of GLP-1 Agonist, SGLT2 Inhibitor and Their Combination","status":"RECRUITING","sponsor":"University of Athens","startDate":"2017-11-03","conditions":"Diabetes Mellitus, Type 2","enrollment":240},{"nctId":"NCT07470905","phase":"NA","title":"Development and Preclinical Validation of DiaBuddy, a Point-of-Care Decision Support Tool for Children With Type 1 Diabetes: A Pilot Clinical Study","status":"COMPLETED","sponsor":"Regency Hospital Kanpur","startDate":"2025-07-01","conditions":"Type 1 Diabetes (T1D)","enrollment":25},{"nctId":"NCT06579404","phase":"NA","title":"Closed-loop in Adults With Type 2 Diabetes","status":"RECRUITING","sponsor":"University of Cambridge","startDate":"2024-12-06","conditions":"Type 2 Diabetes Treated With Insulin","enrollment":224},{"nctId":"NCT07329088","phase":"NA","title":"Isoleucine Addition Treatment Effects in a Controlled Diet Study","status":"NOT_YET_RECRUITING","sponsor":"Jean L. Fry","startDate":"2026-05-04","conditions":"Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Metabolic Syndrome (MetS), Obesity & Overweight","enrollment":40},{"nctId":"NCT07408141","phase":"","title":"MiniMed Fit Payload Wear Study","status":"RECRUITING","sponsor":"Medtronic Diabetes","startDate":"2026-02-19","conditions":"Diabetes (Insulin-requiring, Type 1 or Type 2)","enrollment":175},{"nctId":"NCT06686329","phase":"NA","title":"Physical Activity to Prevent and Treat Hyperglycemia From a Mistimed Bolus Insulin Dose","status":"RECRUITING","sponsor":"Jane Yardley","startDate":"2025-03-17","conditions":"Type 1 Diabetes Mellitus","enrollment":30},{"nctId":"NCT07468097","phase":"","title":"The Impact of Metabolic Status on Pain and Central Sensitization in Women With Lipedema: A Cross-Sectional Observational Study","status":"RECRUITING","sponsor":"Marmara University","startDate":"2026-03-09","conditions":"Central Sensitization, Lipedema, Pain","enrollment":59},{"nctId":"NCT07468188","phase":"NA","title":"Diabetes Body Project 2","status":"RECRUITING","sponsor":"Joslin Diabetes Center","startDate":"2025-01-24","conditions":"Eating Disorders, Type 2 Diabetes","enrollment":42},{"nctId":"NCT02846571","phase":"PHASE1, PHASE2","title":"Pancreatic Islet Transplantation Into the Anterior Chamber of the Eye","status":"RECRUITING","sponsor":"Midhat H. Abdulreda","startDate":"2019-12-05","conditions":"Diabetes","enrollment":2},{"nctId":"NCT05418699","phase":"","title":"Real-life Data From Diabetic Patients on Closed-loop Pumps","status":"COMPLETED","sponsor":"Groupe Hospitalier de la Rochelle Ré Aunis","startDate":"2022-09-26","conditions":"Type 1 Diabetes","enrollment":410},{"nctId":"NCT07467967","phase":"NA","title":"Impact of Date Consumption on Metabolic Control and Oxidative Stress in Patients With Type 2 Diabetes","status":"NOT_YET_RECRUITING","sponsor":"University Tunis El Manar","startDate":"2026-07-15","conditions":"Diabete Type 2","enrollment":130},{"nctId":"NCT07464223","phase":"","title":"MRI Assessment of Pancreatic Fat Changes and Islet Function Recovery After Bariatric Surgery in Obese Patients","status":"ACTIVE_NOT_RECRUITING","sponsor":"yu li，MD","startDate":"2024-09-01","conditions":"Obesity & Overweight, Type 2 Diabetes Mellitus (T2DM), Pancreatic Steatosis","enrollment":50},{"nctId":"NCT06872333","phase":"PHASE2","title":"Allo HSCT for High Risk Hemoglobinopathies","status":"RECRUITING","sponsor":"Masonic Cancer Center, University of Minnesota","startDate":"2024-11-19","conditions":"Graft Failure, Sickle Cell Disease, Hemoglobinopathies","enrollment":62},{"nctId":"NCT07137585","phase":"PHASE1","title":"A Study to Evaluate the Effect of RO7204239 on Insulin Sensitivity and Muscle Composition in Participants With Type 2 Diabetes Mellitus (T2DM) and Overweight or Obesity","status":"RECRUITING","sponsor":"Hoffmann-La Roche","startDate":"2025-09-30","conditions":"Type 2 Diabetes Mellitus, Obesity, Overweight","enrollment":30},{"nctId":"NCT06334133","phase":"PHASE3","title":"Cadisegliatin as Adjunctive Therapy to Insulin in Participants With Type 1 Diabetes","status":"RECRUITING","sponsor":"vTv Therapeutics","startDate":"2024-06-14","conditions":"Diabetes Mellitus, Type 1","enrollment":150},{"nctId":"NCT07463417","phase":"NA","title":"Evaluating the SWW Method Dietary Intervention for HbA1c and Weight Management as a Preventative Intervention in Women","status":"COMPLETED","sponsor":"Sarah Wragge Wellness","startDate":"2024-04-01","conditions":"Metabolic Syndrome, Obesity & Overweight, Blood Glucose Monitoring","enrollment":85},{"nctId":"NCT06982313","phase":"","title":"Long-term Follow-up of the TAM-01 Study and Pooled Analysis of Low-dose Tamoxifen Studies in Non-invasive or Microinvasive Breast Neoplasms","status":"COMPLETED","sponsor":"Ente Ospedaliero Ospedali Galliera","startDate":"1996-07-01","conditions":"Breast Cancer Invasive","enrollment":1545},{"nctId":"NCT04149262","phase":"","title":"Fiasp® Versus NovoRapid® in Children With Type 1 Diabetes on MiniMed 640G Pump With Sensor","status":"COMPLETED","sponsor":"Aristotle University Of Thessaloniki","startDate":"2019-11-15","conditions":"Type 1 Diabetes","enrollment":44},{"nctId":"NCT06945406","phase":"PHASE1","title":"A Study of LY4057996 in Healthy Participants and Participants With Type 1 and Type 2 Diabetes","status":"RECRUITING","sponsor":"Eli Lilly and Company","startDate":"2025-05-16","conditions":"Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2","enrollment":124},{"nctId":"NCT07465224","phase":"PHASE2","title":"A Study to Evaluate ALN-4324 on Insulin Sensitivity in Adults With Type 2 Diabetes Mellitus","status":"RECRUITING","sponsor":"Alnylam Pharmaceuticals","startDate":"2026-01-15","conditions":"Type 2 Diabetes Mellitus (T2DM)","enrollment":40}],"_emaApprovals":[],"_faersSignals":[{"count":17,"reaction":"DRUG INTERACTION"},{"count":9,"reaction":"GASTROINTESTINAL HAEMORRHAGE"},{"count":7,"reaction":"HYPOGLYCAEMIA"},{"count":6,"reaction":"HYPERGLYCAEMIA"},{"count":5,"reaction":"BLOOD GLUCOSE INCREASED"},{"count":5,"reaction":"BRADYCARDIA"},{"count":5,"reaction":"PLEURAL EFFUSION"},{"count":5,"reaction":"PNEUMONIA"},{"count":5,"reaction":"RENAL FAILURE ACUTE"},{"count":5,"reaction":"THROMBOCYTOPENIA"}],"_approvalHistory":[],"publicationCount":55,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Actrapid"],"phase":"marketed","status":"active","brandName":"Insulin Actrapid","genericName":"Insulin Actrapid","companyName":"University of Nottingham","companyId":"university-of-nottingham","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Insulin Actrapid is a rapid-acting insulin that binds to insulin receptors on cells to promote glucose uptake and utilization, lowering blood glucose levels. Used for Type 1 diabetes mellitus, Type 2 diabetes mellitus.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}