{"id":"instillation-exparel","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Vomiting"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"EXPAREL contains liposomal bupivacaine, which encapsulates bupivacaine in lipid vesicles to enable slow, sustained release of the anesthetic over several days. By blocking voltage-gated sodium channels in peripheral nerves, it prevents pain signal transmission from the surgical site. This extended-release formulation provides analgesia for up to 72 hours following infiltration or nerve block administration.","oneSentence":"EXPAREL is a long-acting local anesthetic that blocks sodium channels in nerve fibers to provide prolonged post-operative pain relief.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:49:08.756Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Infiltration anesthesia for post-operative analgesia in surgical patients"},{"name":"Interscalene brachial plexus nerve block for post-operative pain management"}]},"trialDetails":[{"nctId":"NCT01582490","phase":"PHASE4","title":"Study of EXPAREL in Patients Undergoing Breast Augmentation","status":"COMPLETED","sponsor":"Pacira Pharmaceuticals, Inc","startDate":"2012-04","conditions":"Mammoplasty, Postoperative Pain","enrollment":19}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["bupivacaine liposomal injectable suspension"],"phase":"marketed","status":"active","brandName":"Instillation - EXPAREL","genericName":"Instillation - EXPAREL","companyName":"Pacira Pharmaceuticals, Inc","companyId":"pacira-pharmaceuticals-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"EXPAREL is a long-acting local anesthetic that blocks sodium channels in nerve fibers to provide prolonged post-operative pain relief. Used for Infiltration anesthesia for post-operative analgesia in surgical patients, Interscalene brachial plexus nerve block for post-operative pain management.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}