{"id":"inositol-nicotinate","rwe":[],"tags":[{"label":"inositol nicotinate","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"C04AC03","category":"atc"},{"label":"Oral","category":"route"},{"label":"Capsule","category":"form"},{"label":"Active","category":"status"},{"label":"Niacin deficiency","category":"indication"},{"label":"Pellagra","category":"indication"},{"label":"Cardiovascular Agents","category":"pharmacology"},{"label":"Vasodilator Agents","category":"pharmacology"}],"phase":"marketed","safety":{"commonSideEffects":[],"contraindications":["Acute cerebrovascular insufficiency","Acute coronary syndrome","Alcoholism","Arterial hemorrhage","Blood coagulation disorder","Breastfeeding (mother)","Cerebral infarction","Cerebrovascular accident","Diabetes mellitus","Disease of liver","Disorder of coronary artery","Gout","Hyperglycemia","Hypophosphatemia","Liver function tests abnormal","Low blood pressure","Myocardial infarction","Peptic ulcer","Pregnancy, function","Thrombocytopenic disorder"]},"trials":[],"aliases":[],"patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=inositol nicotinate","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T01:04:24.888179+00:00"},"timeline":{"url":"https://en.wikipedia.org/wiki/Inositol Nicotinate","method":"deterministic","source":"Wikipedia","rawText":"","confidence":0.8,"sourceType":"wikipedia","retrievedAt":"2026-04-20T01:04:38.996812+00:00"},"aiSummary":{"url":"","method":"ai_extraction","source":"AI Strategic Summary","aiModel":"featherless","rawText":"","confidence":0.9,"sourceType":"ai_extraction","retrievedAt":"2026-04-20T01:04:51.145763+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T01:04:37.103484+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=inositol nicotinate","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T01:04:37.853184+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1094982/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T01:04:38.855285+00:00"}},"allNames":"hexanicit","offLabel":[],"synonyms":["inositol niacinate","hexanicit","hexanicotinoyl inositol","hexanicotol","inositol hexaniacinate","inositol hexanicotinate","inositol nicotinate"],"timeline":[],"aiSummary":"Inositol nicotinate (Hexanicit) is a marketed drug primarily indicated for niacin deficiency, positioned as a precursor to niacin, an essential nutrient. Its key strength lies in its unique mechanism of action, providing a different formulation compared to direct nicotinic acid, which has been on the market since 1957. The primary risk is the key composition patent expiry in 2028, which could lead to increased competition from generics.","approvals":[{"date":"","orphan":false,"company":"","regulator":"FDA"}],"brandName":"Hexanicit","ecosystem":[{"indication":"Niacin deficiency","otherDrugs":[{"name":"inositol","slug":"inositol","company":""},{"name":"nicotinamide","slug":"nicotinamide","company":"Hospira"},{"name":"nicotine","slug":"nicotine","company":"Sanofi Aventis Us"}],"globalPrevalence":null},{"indication":"Pellagra","otherDrugs":[{"name":"inositol","slug":"inositol","company":""},{"name":"nicotinamide","slug":"nicotinamide","company":"Hospira"},{"name":"nicotine","slug":"nicotine","company":"Sanofi Aventis Us"}],"globalPrevalence":null}],"mechanism":{"novelty":"First-in-class","modality":"Small Molecule","drugClass":"inositol nicotinate","explanation":"","oneSentence":"","technicalDetail":"Hexanicit is a prodrug that is metabolized to inositol hexanicotinate, which is then converted to Niacin through a series of enzymatic reactions."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Inositol_nicotinate","title":"Inositol nicotinate","extract":"Inositol nicotinate, also known as inositol hexanicotinate or inositol hexaniacinate, is a compound of niacin and inositol. It is marketed in the United States as a \"no-flush\" form of niacin in dietary supplements."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1445","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=inositol%20nicotinate","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=inositol nicotinate","fields":["publications"],"source":"PubMed/NCBI"},{"id":4,"url":"https://en.wikipedia.org/wiki/Inositol_nicotinate","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T12:05:06.271249","_validation":{"fieldsValidated":1,"lastValidatedAt":"2026-04-20T01:04:51.146441+00:00","fieldsConflicting":2,"overallConfidence":0.8},"biosimilars":[],"competitors":[{"drugName":"nicotinic 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