{"id":"inositol-high-volume","_chembl":{"chemblId":"CHEMBL1094982","moleculeType":"Small molecule","molecularWeight":"810.73"},"modality":"Small molecule","_dailymed":null,"mechanism":{"explanation":"Inositol is incorporated into phospholipids and participates in intracellular signaling pathways. In neonates, it may enhance lung maturation by promoting surfactant synthesis and reducing inflammatory responses in developing lung tissue.","oneSentence":"Inositol acts as a precursor for phosphatidylinositol synthesis, supporting cellular membrane function and pulmonary surfactant production."},"_scrapedAt":"2026-03-28T03:36:52.060Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"_claudeStub":{"ts":1779123936,"model":"claude-sonnet-4-5-20250929"},"competitors":[{"name":"Caffeine citrate","brand":"Cafcit","company":null,"rationale":"Used to prevent bronchopulmonary dysplasia in preterm infants"},{"name":"Beractant","brand":"Survanta","company":"AbbVie","rationale":"Pulmonary surfactant for respiratory distress syndrome in neonates"}],"description":"Inositol high volume is an investigational nutritional supplement being studied by the NICHD Neonatal Research Network in Phase 2 trials. Inositol is a naturally occurring sugar alcohol that plays a role in cellular signaling and surfactant production in premature infants.","indications":{"approved":[{"status":"investigational","condition":"Bronchopulmonary dysplasia prevention","patientPopulation":"Preterm infants"},{"status":"investigational","condition":"Respiratory distress syndrome prevention","patientPopulation":"Preterm infants"}]},"trialDetails":[{"nctId":"NCT01030575","phase":"PHASE2","title":"Multi-dose Pharmacokinetics and Dose Ranging of Inositol in Premature Infants (INS-2)","status":"COMPLETED","sponsor":"NICHD Neonatal Research Network","startDate":"2010-01","conditions":"Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age","enrollment":125},{"nctId":"NCT00349726","phase":"PHASE2","title":"Single-Dose Intravenous Inositol Pharmacokinetics in Preterm Infants","status":"COMPLETED","sponsor":"NICHD Neonatal Research Network","startDate":"2006-06","conditions":"Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age","enrollment":74},{"nctId":"NCT01738763","phase":"NA","title":"Effects of Different Doses of Pinitol on Carbohydrate Metabolism Parameters in Healthy Subjects","status":"COMPLETED","sponsor":"University of Valencia","startDate":"2011-07","conditions":"Healthy, Insulin Sensitivity","enrollment":30}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":4,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Myo-inositol 5%"],"phase":"phase_2","status":"active","brandName":"Inositol high volume","genericName":"Inositol high volume","companyName":"NICHD Neonatal Research Network","companyId":"nichd-neonatal-research-network","firstApprovalDate":"","aiSummary":"","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}