{"id":"inositol","rwe":[],"tags":[{"label":"inositol","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"A11HA07","category":"atc"},{"label":"Oral","category":"route"},{"label":"Intramuscular","category":"route"},{"label":"Injection","category":"form"},{"label":"Tablet","category":"form"},{"label":"Active","category":"status"},{"label":"Hypercholesterolemia","category":"indication"},{"label":"Hypertriglyceridemia","category":"indication"},{"label":"Hypoalphalipoproteinemia","category":"indication"},{"label":"Mixed hyperlipidemia","category":"indication"},{"label":"Myocardial Reinfarction Prevention","category":"indication"},{"label":"Niacin deficiency","category":"indication"},{"label":"Micronutrients","category":"pharmacology"},{"label":"Vitamin B Complex","category":"pharmacology"},{"label":"Vitamins","category":"pharmacology"}],"phase":"discontinued","safety":{"safetySignals":[{"llr":62.531,"date":"","count":10,"signal":"Needle fatigue","source":"DrugCentral FAERS","actionTaken":"Reported 10 times (LLR=63)"},{"llr":59.416,"date":"","count":10,"signal":"Gait spastic","source":"DrugCentral FAERS","actionTaken":"Reported 10 times (LLR=59)"},{"llr":57.764,"date":"","count":10,"signal":"Relapsing-remitting multiple sclerosis","source":"DrugCentral FAERS","actionTaken":"Reported 10 times (LLR=58)"},{"llr":53.884,"date":"","count":25,"signal":"Exposure during pregnancy","source":"DrugCentral FAERS","actionTaken":"Reported 25 times (LLR=54)"},{"llr":53.358,"date":"","count":12,"signal":"Normal newborn","source":"DrugCentral FAERS","actionTaken":"Reported 12 times (LLR=53)"},{"llr":52.056,"date":"","count":11,"signal":"Hypertonic bladder","source":"DrugCentral FAERS","actionTaken":"Reported 11 times (LLR=52)"}],"commonSideEffects":[{"effect":"Allergic sensitization","drugRate":"reported","severity":"unknown"},{"effect":"Nausea","drugRate":"reported","severity":"unknown"}],"contraindications":["Acute cerebrovascular insufficiency","Acute coronary syndrome","Alcoholism","Arterial hemorrhage","Blood coagulation disorder","Breastfeeding (mother)","Cerebral infarction","Cerebrovascular accident","Diabetes mellitus","Disease of liver","Disorder of coronary artery","Gout","Hyperglycemia","Hypophosphatemia","Liver function tests abnormal","Low blood pressure","Myocardial infarction","Peptic ulcer","Pregnancy, function","Thrombocytopenic disorder"]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"inosital","offLabel":[],"synonyms":["inositol","myo-Inositol","cyclohexanehexol","cyclohexitol","inosital","inositene","inositina","mesoinositol","myoinosite","myoinositol"],"timeline":[],"approvals":[{"date":"","orphan":false,"company":"","regulator":"FDA"}],"brandName":"Inosital","ecosystem":[{"indication":"Hypercholesterolemia","otherDrugs":[{"name":"alirocumab","slug":"alirocumab","company":"Sanofi Aventis"},{"name":"atorvastatin","slug":"atorvastatin","company":"Pfizer"},{"name":"cerivastatin","slug":"cerivastatin","company":"Bayer Pharms"},{"name":"cholestyramine","slug":"cholestyramine","company":"Bristol Myers"}],"globalPrevalence":390000000},{"indication":"Hypertriglyceridemia","otherDrugs":[{"name":"atorvastatin","slug":"atorvastatin","company":"Pfizer"},{"name":"choline fenofibrate","slug":"choline-fenofibrate","company":"Abbvie"},{"name":"fenofibrate","slug":"fenofibrate","company":"Abbvie"},{"name":"gemfibrozil","slug":"gemfibrozil","company":"Pfizer Pharms"}],"globalPrevalence":1680000000},{"indication":"Hypoalphalipoproteinemia","otherDrugs":[{"name":"choline fenofibrate","slug":"choline-fenofibrate","company":"Abbvie"},{"name":"fenofibrate","slug":"fenofibrate","company":"Abbvie"},{"name":"lovastatin","slug":"lovastatin","company":"Merck"},{"name":"simvastatin","slug":"simvastatin","company":"Merck"}],"globalPrevalence":null},{"indication":"Mixed hyperlipidemia","otherDrugs":[{"name":"atorvastatin","slug":"atorvastatin","company":"Pfizer"},{"name":"cerivastatin","slug":"cerivastatin","company":"Bayer Pharms"},{"name":"choline fenofibrate","slug":"choline-fenofibrate","company":"Abbvie"},{"name":"ezetimibe","slug":"ezetimibe","company":"Msd Intl Gmbh"}],"globalPrevalence":390000000},{"indication":"Myocardial Reinfarction Prevention","otherDrugs":[{"name":"apixaban","slug":"apixaban","company":"Bristol Myers Squibb"},{"name":"clopidogrel","slug":"clopidogrel","company":"Sanofi Aventis Us"},{"name":"lovastatin","slug":"lovastatin","company":"Merck"},{"name":"metoprolol","slug":"metoprolol","company":"Us Pharms Holdings I"}],"globalPrevalence":null},{"indication":"Niacin deficiency","otherDrugs":[{"name":"inositol nicotinate","slug":"inositol-nicotinate","company":""},{"name":"nicotinamide","slug":"nicotinamide","company":"Hospira"},{"name":"nicotine","slug":"nicotine","company":"Sanofi Aventis Us"}],"globalPrevalence":null},{"indication":"Pellagra","otherDrugs":[{"name":"inositol nicotinate","slug":"inositol-nicotinate","company":""},{"name":"nicotinamide","slug":"nicotinamide","company":"Hospira"},{"name":"nicotine","slug":"nicotine","company":"Sanofi Aventis Us"}],"globalPrevalence":null},{"indication":"Slow Progression of Coronary Artery Disease","otherDrugs":[{"name":"atorvastatin","slug":"atorvastatin","company":"Pfizer"},{"name":"fluvastatin","slug":"fluvastatin","company":"Novartis"},{"name":"lovastatin","slug":"lovastatin","company":"Merck"},{"name":"pravastatin","slug":"pravastatin","company":"Bristol Myers Squibb"}],"globalPrevalence":null}],"mechanism":{"novelty":"First-in-class","modality":"Small Molecule","drugClass":"inositol","explanation":"Think of Inosital like a key that helps unlock the body's natural ability to regulate cholesterol and triglyceride levels. When we eat, our body breaks down fats into smaller particles called lipids, which can be either good or bad for our health. Inosital helps the body use these lipids more efficiently, reducing the risk of conditions like high cholesterol and heart disease.","oneSentence":"Inosital works by influencing the metabolism of lipids in the body.","technicalDetail":"Inosital is believed to exert its effects through the regulation of inositol phosphate metabolism, influencing the activity of various enzymes and receptors involved in lipid metabolism."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Inositol","title":"Inositol","extract":"In biochemistry, medicine, and related sciences, inositol generally refers to myo-inositol, the most important stereoisomer of the chemical compound cyclohexane-1,2,3,4,5,6-hexol. Its formula is C6H12O6; the molecule has a ring of six carbon atoms, each with a hydrogen atom and a hydroxy group (–OH). In myo-inositol, two of the hydroxyls, neither adjacent nor opposite, lie above the respective hydrogens relative to the mean plane of the ring.","wiki_history":"==History==\nmyo-Inositol was first isolated from muscle extracts by Johanes Joseph Scherer (1814–1869) in 1850. It was formerly called meso-inositol to distinguish it from the chiro- isomers. However, since all other isomers are meso (non-chiral) compounds, the name myo-inositol is now preferred (myo- being a medical prefix for \"muscle\").\n\nInositol was once considered a member of the vitamin B complex, namely vitamin B<sub>8</sub> before the discovery that it is made naturally in the human body, and therefore cannot be a vitamin or essential nutrient."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1444","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=INOSITOL","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=INOSITOL","fields":["publications"],"source":"PubMed/NCBI"},{"id":4,"url":"https://en.wikipedia.org/wiki/Inositol","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T13:58:10.813001","biosimilars":[],"competitors":[{"drugName":"nicotinamide","drugSlug":"nicotinamide","fdaApproval":"1953-02-20","relationship":"same-class"},{"drugName":"pyridoxine","drugSlug":"pyridoxine","fdaApproval":"1993-12-29","genericCount":10,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"Vitamin E","drugSlug":"vitamin-e","fdaApproval":"1953-02-20","relationship":"same-class"},{"drugName":"riboflavin","drugSlug":"riboflavin","fdaApproval":"1953-02-20","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"biotin","drugSlug":"biotin","fdaApproval":"1953-02-20","relationship":"same-class"},{"drugName":"pyridoxal phosphate","drugSlug":"pyridoxal-phosphate","fdaApproval":"","relationship":"same-class"},{"drugName":"tocofersolan","drugSlug":"tocofersolan","fdaApproval":"","relationship":"same-class"},{"drugName":"dexpanthenol","drugSlug":"dexpanthenol","fdaApproval":"1953-02-20","relationship":"same-class"},{"drugName":"calcium pantothenate","drugSlug":"calcium-pantothenate","fdaApproval":"1993-12-29","relationship":"same-class"},{"drugName":"pantethine","drugSlug":"pantethine","fdaApproval":"","relationship":"same-class"}],"genericName":"inositol","indications":{"approved":[{"name":"Hypercholesterolemia","source":"DrugCentral","snomedId":13644009,"regulator":"FDA","eligibility":"Not specified","usPrevalence":86000000,"globalPrevalence":390000000,"prevalenceMethod":"curated","prevalenceSource":"WHO Global Health Estimates, 2023"},{"name":"Hypertriglyceridemia","source":"DrugCentral","snomedId":302870006,"regulator":"FDA","eligibility":"Not specified","usPrevalence":null,"globalPrevalence":1680000000,"prevalenceMethod":"curated","prevalenceSource":"J Health Popul Nutr, 2025 (PMID:40859400)"},{"name":"Hypoalphalipoproteinemia","source":"DrugCentral","snomedId":190785000,"regulator":"FDA","eligibility":"Not specified"},{"name":"Mixed hyperlipidemia","source":"DrugCentral","snomedId":267434003,"regulator":"FDA","eligibility":"Not specified","usPrevalence":null,"globalPrevalence":390000000,"prevalenceMethod":"curated","prevalenceSource":"WHO, 2023"},{"name":"Myocardial Reinfarction Prevention","source":"DrugCentral","snomedId":"","regulator":"FDA","eligibility":"Not specified"},{"name":"Niacin deficiency","source":"DrugCentral","snomedId":418279001,"regulator":"FDA","eligibility":"Not specified"},{"name":"Pellagra","source":"DrugCentral","snomedId":418186002,"regulator":"FDA","eligibility":"Not specified"},{"name":"Slow Progression of Coronary Artery Disease","source":"DrugCentral","snomedId":"","regulator":"FDA","eligibility":"Not specified"}],"offLabel":[{"name":"Hyperlipidemia","source":"DrugCentral","drugName":"INOSITOL","evidenceCount":118,"evidenceLevel":"strong"}],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"nicotinamide","brandName":"nicotinamide","genericName":"nicotinamide","approvalYear":"1953","relationship":"same-class"},{"drugId":"pyridoxine","brandName":"pyridoxine","genericName":"pyridoxine","approvalYear":"1993","relationship":"same-class"},{"drugId":"vitamin-e","brandName":"Vitamin E","genericName":"Vitamin E","approvalYear":"1953","relationship":"same-class"},{"drugId":"riboflavin","brandName":"riboflavin","genericName":"riboflavin","approvalYear":"1953","relationship":"same-class"},{"drugId":"biotin","brandName":"biotin","genericName":"biotin","approvalYear":"1953","relationship":"same-class"},{"drugId":"pyridoxal-phosphate","brandName":"pyridoxal phosphate","genericName":"pyridoxal phosphate","approvalYear":"","relationship":"same-class"},{"drugId":"tocofersolan","brandName":"tocofersolan","genericName":"tocofersolan","approvalYear":"","relationship":"same-class"},{"drugId":"dexpanthenol","brandName":"dexpanthenol","genericName":"dexpanthenol","approvalYear":"1953","relationship":"same-class"},{"drugId":"calcium-pantothenate","brandName":"calcium pantothenate","genericName":"calcium pantothenate","approvalYear":"1993","relationship":"same-class"},{"drugId":"pantethine","brandName":"pantethine","genericName":"pantethine","approvalYear":"","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT04407754","phase":"NA","title":"Myo-Inositol for Infertility in PCOS","status":"RECRUITING","sponsor":"University of Oklahoma","startDate":"2022-02-07","conditions":["Polycystic Ovary Syndrome"],"enrollment":168,"completionDate":"2026-12"},{"nctId":"NCT07465575","phase":"NA","title":"Berberine Phytosome for Signs and Symptoms of Polycystic Ovary Syndrome (PCOS)","status":"NOT_YET_RECRUITING","sponsor":"Liaquat University of Medical & Health Sciences","startDate":"2026-03-16","conditions":["Polycystic Ovary Syndrome"],"enrollment":150,"completionDate":"2027-03-31"},{"nctId":"NCT03911414","phase":"PHASE4","title":"A Clinical Trial Via Telepsychiatry of Treatments for the Management of Emotional Dysregulation in Youth","status":"COMPLETED","sponsor":"Massachusetts General Hospital","startDate":"2019-06-18","conditions":["Mood Disturbance","Mood Disorders","Natural Supplements","Alternative Treatment"],"enrollment":27,"completionDate":"2024-12-04"},{"nctId":"NCT06551285","phase":"NA","title":"Study of the Effect of a Nutritional Supplement on Microbiota, Metabolic Control, Inflammatory Profile, and Quality of Life in Patients With Polycystic Ovary Syndrome.","status":"RECRUITING","sponsor":"Celia Bañuls","startDate":"2024-02-01","conditions":["Polycystic Ovary Syndrome","Metabolic Syndrome"],"enrollment":120,"completionDate":"2029-05-31"},{"nctId":"NCT07459595","phase":"PHASE1","title":"Metformin Versus Myo-inositol in the Management of Polycystic Ovarian Disease: A Comparative Study","status":"NOT_YET_RECRUITING","sponsor":"Fatima Tariq","startDate":"2026-05-01","conditions":["Polycystic Ovarian Syndrome (PCOS)"],"enrollment":60,"completionDate":"2026-07-31"},{"nctId":"NCT07453680","phase":"NA","title":"Comparative Effect of Myo-inositol With That of D-chiro-inositol on Insulin Resistance in Infertile Women With Polycystic Ovary Syndrome (PCOS).","status":"COMPLETED","sponsor":"Mst.Sumyara Khatun","startDate":"2023-06-01","conditions":["PCOS (Polycystic Ovary Syndrome)"],"enrollment":80,"completionDate":"2024-05-01"},{"nctId":"NCT07257770","phase":"NA","title":"Local Treatment of Breast Pain Based on the Daily Use of a Topical Gel","status":"RECRUITING","sponsor":"Lo.Li.Pharma s.r.l","startDate":"2025-09-11","conditions":["Mastalgia"],"enrollment":50,"completionDate":"2026-07-11"},{"nctId":"NCT05448365","phase":"NA","title":"Vitamin D, Epigallocatechin Gallate, D-chiro-inositol and Vitamin B6 in Uterine Fibroid","status":"RECRUITING","sponsor":"Lo.Li.Pharma s.r.l","startDate":"2022-07-01","conditions":["Uterine Fibroids","D-chiro-inositol","Inositol","Epigallocatechin Gallate","Vitamin D","Vitamin B6"],"enrollment":60,"completionDate":"2026-07-01"},{"nctId":"NCT05767515","phase":"NA","title":"The Effects of Acetyl-L-Carnitine and Myo/Chiro-Inositol in Patients With PCOS","status":"COMPLETED","sponsor":"Khyber Medical University Peshawar","startDate":"2023-07-15","conditions":["Infertility, Female","PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries"],"enrollment":120,"completionDate":"2024-03-10"},{"nctId":"NCT07387679","phase":"NA","title":"Myo-inositol Versus Metformin in Patients With Polycystic Ovarian Syndrome to Treat Obesity","status":"COMPLETED","sponsor":"Muhammad Aamir Latif","startDate":"2024-11-29","conditions":["Polycystic Ovarian Syndrome"],"enrollment":60,"completionDate":"2025-05-28"},{"nctId":"NCT07380841","phase":"NA","title":"Metformin vs Inositol vs Diet vs Combination Therapy in PCOS","status":"COMPLETED","sponsor":"Islamabad Medical and Dental College","startDate":"2025-05-21","conditions":["Polycystic Ovary Syndrome","Insulin Resistance","Metabolic Syndrome"],"enrollment":192,"completionDate":"2026-01-13"},{"nctId":"NCT07323589","phase":"PHASE3","title":"Impact of Myo-Inositol Alone vs Myo-Inositol Plus Metformin on Conception, Adherence, and Tolerability in PCOS","status":"COMPLETED","sponsor":"PAEC general hospital","startDate":"2025-01-01","conditions":["PCOS (Polycystic Ovary Syndrome)"],"enrollment":120,"completionDate":"2025-10-25"},{"nctId":"NCT03864068","phase":"PHASE2","title":"Inositol Supplementation to Treat PCOS (INSUPP-PCOS)","status":"COMPLETED","sponsor":"Milton S. Hershey Medical Center","startDate":"2020-01-24","conditions":["Polycystic Ovary Syndrome","Anovulation","Hyperandrogenism","Insulin Resistance","Glucose Intolerance","Metabolic Complication"],"enrollment":154,"completionDate":"2025-12-10"},{"nctId":"NCT06800170","phase":"NA","title":"Treatment of Menstrual Cycle Alterations in Adolescents","status":"RECRUITING","sponsor":"Lo.Li.Pharma s.r.l","startDate":"2025-06-01","conditions":["Amenorrhea","Oligomenorrhea","PCOS (Polycystic Ovary Syndrome)"],"enrollment":20,"completionDate":"2026-12"},{"nctId":"NCT05689710","phase":"NA","title":"The Effects of Inositol on Glucose Metabolism in Patients With Metabolic Syndrome at Risk of Cardiac Fibrosis","status":"SUSPENDED","sponsor":"Lo.Li.Pharma s.r.l","startDate":"2022-12-23","conditions":["Metabolic Syndrome","Cardiac Fibrosis"],"enrollment":30,"completionDate":"2026-01"},{"nctId":"NCT03875755","phase":"NA","title":"Myo-inositol for Reduction of Insulin Therapy in Gestational Diabetes Mellitus","status":"ACTIVE_NOT_RECRUITING","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2020-03-04","conditions":["Gestational Diabetes Mellitus"],"enrollment":1080,"completionDate":"2027-01-20"},{"nctId":"NCT07266259","phase":"NA","title":"Effect of Levocarnitine Plus Myoinositol Versus Myoinositol Alone on Hormonal and Insulin Resistance in PCOS Women","status":"RECRUITING","sponsor":"Mst.Sumyara Khatun","startDate":"2025-09-19","conditions":["Polycystic Ovary Syndrome (PCOS)"],"enrollment":72,"completionDate":"2027-03-01"},{"nctId":"NCT07242131","phase":"NA","title":"Efficacy of Oral Contraceptive, Progesterone, and Inositol on Menstrual Regulation in PCOS","status":"RECRUITING","sponsor":"Ege University","startDate":"2025-12-01","conditions":["Polycystic Ovary Syndrome (PCOS)"],"enrollment":150,"completionDate":"2026-06-01"},{"nctId":"NCT06571279","phase":"NA","title":"Assessing the Impact of a Plant-Based Diet for Diabetes Prevention","status":"COMPLETED","sponsor":"Jean L. Fry","startDate":"2024-10-14","conditions":["Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)"],"enrollment":9,"completionDate":"2025-11-25"},{"nctId":"NCT07241221","phase":"NA","title":"Antenatal Myo-inositol Supplementation in Pre-existing Diabetes","status":"RECRUITING","sponsor":"National University Hospital, Singapore","startDate":"2025-12","conditions":["Perinatal and Neonatal Outcomes in Pregnancies With Type 2 Diabetes Mellitus (T2DM)"],"enrollment":182,"completionDate":"2029-08-31"},{"nctId":"NCT06158659","phase":"NA","title":"Improved Immunology Outcomes Associated With Lactoferrin Fortified With HMO in Infant Formula","status":"COMPLETED","sponsor":"Heilongjiang Feihe Dairy Co. Ltd.","startDate":"2023-11-14","conditions":["Flu","Cold"],"enrollment":240,"completionDate":"2025-04-03"},{"nctId":"NCT06159088","phase":"NA","title":"Improved Gut Health Outcomes Associated With Probiotics Fortified With Hydrolyzed Whey Protein in Infant Formula","status":"COMPLETED","sponsor":"Heilongjiang Feihe Dairy Co. Ltd.","startDate":"2023-11-14","conditions":["Gut Health","Gastrointestinal Diseases"],"enrollment":240,"completionDate":"2025-04-03"},{"nctId":"NCT06146387","phase":"NA","title":"Improved Cognitive Outcomes Associated With Feihe HMO With DHA/ARA in Infant Formula","status":"COMPLETED","sponsor":"Heilongjiang Feihe Dairy Co. Ltd.","startDate":"2023-11-14","conditions":["Cognitive Change"],"enrollment":240,"completionDate":"2025-04-03"},{"nctId":"NCT06768086","phase":"","title":"Preoperative Administration of EGCG, Vitamin D and DCI Prior Hysteroscopic Myomectomy","status":"COMPLETED","sponsor":"Centro di Ricerca Clinica Salentino","startDate":"2025-02-01","conditions":["Uterine Fibroids","Hysteroscopic Myomectomy","Treatment Compliance","Patient Compliance","Treatment Complication"],"enrollment":90,"completionDate":"2025-11-25"},{"nctId":"NCT04670393","phase":"NA","title":"Antioxidant Supplement Associated With Oral Probiotics in Patients With PCOS in IVF","status":"COMPLETED","sponsor":"Fertypharm","startDate":"2020-12-02","conditions":["Infertility, Female","Polycystic Ovary Syndrome"],"enrollment":20,"completionDate":"2025-01-23"},{"nctId":"NCT07256769","phase":"","title":"Vitamin k, D-chiro Inositol and α-lactalbumin in Bone Homeostasis","status":"RECRUITING","sponsor":"Regina Elena Cancer Institute","startDate":"2025-09-29","conditions":["Osteoporosis Secondary","Breast Cancer Females"],"enrollment":134,"completionDate":"2028-03-31"},{"nctId":"NCT05934422","phase":"NA","title":"NiPPeR Randomised Trial - Child Follow Up Study","status":"COMPLETED","sponsor":"University of Southampton","startDate":"2023-06-16","conditions":["Obesity, Childhood","Cognition","Neurobehavioral Manifestations","Metabolic Disturbance","Growth Disorders","Allergy","Atopic Dermatitis","Atopy","Nutrition, Healthy","Lifestyle","Microbial Colonization","Breastfeeding"],"enrollment":461,"completionDate":"2025-08-14"},{"nctId":"NCT07211841","phase":"NA","title":"Correlative Analysis Between Magnetic Resonance Spectroscopy (MRS) and Essential Clinicobiological Data in Glioblatoma Multiforme (GBM)","status":"NOT_YET_RECRUITING","sponsor":"Centre Hospitalier Universitaire, Amiens","startDate":"2025-12","conditions":["Glioblastoma","MRI Spectroscopy","Tumor Microenvironment","Biomarkers / Blood"],"enrollment":30,"completionDate":"2029-04"},{"nctId":"NCT04959864","phase":"NA","title":"Efficacy Study of a Food Supplement With Myo-inositol, N-Acetyl-Cystein, Zinc and Vitamins on Sperm DNA Fragmentation","status":"RECRUITING","sponsor":"GYNOV","startDate":"2021-07-07","conditions":["Male Infertility"],"enrollment":72,"completionDate":"2026-07"},{"nctId":"NCT06573229","phase":"NA","title":"LIver FRAilty Management IN Cirrhosis (LIFRAMIN)","status":"ACTIVE_NOT_RECRUITING","sponsor":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","startDate":"2024-08-02","conditions":["Sarcopenia","Cirrhosis, Liver","Malnutrition; Protein"],"enrollment":30,"completionDate":"2025-10-30"},{"nctId":"NCT06314126","phase":"NA","title":"Evaluation of D-Chiro-Inositol Treatment in Women With Endometriosis","status":"COMPLETED","sponsor":"University of Palermo","startDate":"2024-04-15","conditions":["Endometriosis"],"enrollment":64,"completionDate":"2025-03-15"},{"nctId":"NCT03667443","phase":"NA","title":"Myo-inositol Plus Alpha-lactalbumin in PCOS Myo-inositol-resistant Patients","status":"COMPLETED","sponsor":"Lo.Li.Pharma s.r.l","startDate":"2022-06-13","conditions":["PCOS","Myo-inositol-resistance"],"enrollment":50,"completionDate":"2022-12-19"},{"nctId":"NCT07058675","phase":"NA","title":"Myoinositol vs. Metformin for Polycystic Ovarian Syndrome (PCOS): Impact on Metabolic Health and Fertility","status":"COMPLETED","sponsor":"Benha University","startDate":"2024-11-25","conditions":["PCOS"],"enrollment":156,"completionDate":"2025-06-18"},{"nctId":"NCT04576546","phase":"NA","title":"Inositols and FSH in IVF","status":"COMPLETED","sponsor":"Lo.Li.Pharma s.r.l","startDate":"2020-11-02","conditions":["Amount of FSH Units During Ovarian Stimulation Protocols"],"enrollment":300,"completionDate":"2024-02-27"},{"nctId":"NCT03757585","phase":"PHASE4","title":"Natural Treatments for the Management of Emotional Dysregulation in Youth With Non-verbal Learning Disability (NVLD) and/or Autism Spectrum Disorders (ASD)","status":"COMPLETED","sponsor":"Massachusetts General Hospital","startDate":"2019-05-20","conditions":["Non-verbal Learning Disorder","Autism Spectrum Disorder","Autism"],"enrollment":54,"completionDate":"2024-05-06"},{"nctId":"NCT04745780","phase":"NA","title":"Evaluation of Efficacy and Safety of a Combination Containing Myo-inositol, D-chiro-inositol, Alpha-lactalbumin, Zinc and Extract of Gymnema Sylvestre in Subjects Diabetic Patients.","status":"COMPLETED","sponsor":"Lo.Li.Pharma s.r.l","startDate":"2021-02-10","conditions":["Type 2 Diabetes"],"enrollment":75,"completionDate":"2022-12-22"},{"nctId":"NCT05348941","phase":"NA","title":"Efficacy and Safety of D-chiro-inositol in Obese Patients","status":"COMPLETED","sponsor":"Lo.Li.Pharma s.r.l","startDate":"2022-06-28","conditions":["Insulin Resistance"],"enrollment":44,"completionDate":"2023-11-01"},{"nctId":"NCT05348967","phase":"NA","title":"Combination of D-chiro-inositol With Ketogenic Diet","status":"WITHDRAWN","sponsor":"Lo.Li.Pharma s.r.l","startDate":"2022-10-14","conditions":["Polycystic Ovary Syndrome"],"enrollment":0,"completionDate":"2023-11"},{"nctId":"NCT06575868","phase":"NA","title":"Myo-inositol During Pregnancy to Prevent Gestational Diabetes","status":"RECRUITING","sponsor":"Tufts Medical Center","startDate":"2025-03-01","conditions":["Pregnancy Related"],"enrollment":40,"completionDate":"2027-06-30"},{"nctId":"NCT04801485","phase":"NA","title":"D-chiro Inositol in Prevention of Gestational Diabetes Mellitus in China","status":"COMPLETED","sponsor":"Women's Hospital School Of Medicine Zhejiang University","startDate":"2021-01-01","conditions":["Gestational Diabetes Mellitus in Pregnancy"],"enrollment":291,"completionDate":"2023-05-01"},{"nctId":"NCT04881851","phase":"NA","title":"Effects of Inositol Alone or Associated With Alpha-lipoic Acid in Polycystic Ovary Syndrome Treatment","status":"TERMINATED","sponsor":"Universita di Verona","startDate":"2015-05-07","conditions":["Polycystic Ovary Syndrome"],"enrollment":76,"completionDate":"2025-03-31"},{"nctId":"NCT06867913","phase":"NA","title":"A Study of Selenomethionine and Myo-inositol(SOLOWAYS_TM) in Patients With Autoimmune Thyroiditis Carrying the DIO2 Thr92Ala Polymorphism","status":"COMPLETED","sponsor":"S.LAB (SOLOWAYS)","startDate":"2024-05-15","conditions":["Autoimmune Thyroiditis"],"enrollment":40,"completionDate":"2025-02-21"},{"nctId":"NCT04828278","phase":"NA","title":"Nutrition21 Study 1","status":"COMPLETED","sponsor":"Texas A&M University","startDate":"2020-04-06","conditions":["Nutritional Supplementation"],"enrollment":24,"completionDate":"2021-03-01"},{"nctId":"NCT06715527","phase":"NA","title":"Treatment of Women With Hyperandrogenic PCOS With Two Different Ratios of Myo-inositol:D-chiro-inositol: A Comparison","status":"COMPLETED","sponsor":"Lo.Li.Pharma s.r.l","startDate":"2024-11-01","conditions":["Polycystic Ovarian Syndrome (PCOS)"],"enrollment":30,"completionDate":"2025-03-14"},{"nctId":"NCT06860841","phase":"PHASE4","title":"Effects of D-Chiro-Inositol Combined with Metformin on Insulin Resistance in People with Overweight or Obesity and T2DM","status":"ACTIVE_NOT_RECRUITING","sponsor":"Campus Bio-Medico University","startDate":"2025-01-10","conditions":["Type 2 Diabetes","Overweight and Obese Adults"],"enrollment":16,"completionDate":"2025-04-10"},{"nctId":"NCT05409872","phase":"NA","title":"Effects of Vitamin D, Epigallocatechin Gallate, Vitamin B6, and D-Chiro-inositol Combination on Uterine Fibroids","status":"RECRUITING","sponsor":"Universita di Verona","startDate":"2022-09-15","conditions":["Leiomyoma, Uterine"],"enrollment":108,"completionDate":"2025-12"},{"nctId":"NCT06840613","phase":"NA","title":"Glucophage Plus Myo-Inositol vs Glucophage in Glycemic Control Among Patients With Gestational Diabetes Mellitus","status":"NOT_YET_RECRUITING","sponsor":"University of Health Sciences Lahore","startDate":"2025-03","conditions":["Gestational Diabetes Mellitus (GDM)"],"enrollment":90,"completionDate":"2025-05"},{"nctId":"NCT06736015","phase":"NA","title":"Myo-inositol and Selenium in Indeterminate Thyroid Nodules (TIR3a)","status":"RECRUITING","sponsor":"Regina Elena Cancer Institute","startDate":"2024-10-23","conditions":["Thyroid Nodule"],"enrollment":30,"completionDate":"2026-10-30"},{"nctId":"NCT06729008","phase":"NA","title":"Effect of Diabetes-Specific Nutrition Formula on the Metabolic Parameters of Filipino Adults with Metabolic Syndrome","status":"NOT_YET_RECRUITING","sponsor":"St. Luke's Medical Center, Philippines","startDate":"2025-02-01","conditions":["Metabolic Syndrome"],"enrollment":35,"completionDate":"2025-11"},{"nctId":"NCT06124300","phase":"NA","title":"Effects of a Female Hormone Balance Supplement on Symptoms of Polycystic Ovary Syndrome and Severe Premenstrual Syndrome","status":"COMPLETED","sponsor":"Rael","startDate":"2023-08-30","conditions":["Polycystic Ovary Syndrome","Premenstrual Syndrome"],"enrollment":40,"completionDate":"2024-01-19"},{"nctId":"NCT03283813","phase":"PHASE4","title":"ZIMBA: Clinical Trial in Paediatric Obesity","status":"COMPLETED","sponsor":"Azienda Ospedaliero Universitaria Maggiore della Carita","startDate":"2018-02-05","conditions":["Obesity, Childhood","Insulin Resistance","Zinc Deficiency","Inositol"],"enrollment":56,"completionDate":"2024-03-10"},{"nctId":"NCT06535698","phase":"NA","title":"Evaluating the Effect of a Supplement on Symptoms of Hormonal Imbalance.","status":"COMPLETED","sponsor":"Perelel Inc.","startDate":"2024-02-19","conditions":["Women's Health"],"enrollment":35,"completionDate":"2024-06-10"},{"nctId":"NCT06190054","phase":"NA","title":"Evaluation of Performance and Safety of Eye Drops With Hydroxypropyl-methylcellulose and Inositol in Drye Eye Disease","status":"UNKNOWN","sponsor":"Fidia Farmaceutici s.p.a.","startDate":"2023-02-06","conditions":["Dry Eye Disease Associated to Asthenopia and Accommodative Effort in Video Display Terminal Users"],"enrollment":100,"completionDate":"2024-12"},{"nctId":"NCT06405243","phase":"PHASE3","title":"Myoinositol, L-arginine and Chromium With Letrozole for Ovulation Induction in Polycystic Ovarian Syndrome Patients","status":"NOT_YET_RECRUITING","sponsor":"Beni-Suef University","startDate":"2024-06-30","conditions":["Polycystic Ovary Syndrome"],"enrollment":100,"completionDate":"2024-12-31"},{"nctId":"NCT06405204","phase":"PHASE3","title":"of Myo-inositol, Melatonin and Co-enzyme q10 on Ovarian Reserve","status":"NOT_YET_RECRUITING","sponsor":"Beni-Suef University","startDate":"2024-06-30","conditions":["IVF"],"enrollment":200,"completionDate":"2024-12-30"},{"nctId":"NCT06398145","phase":"PHASE2","title":"D-chiro-inositol and AUB","status":"NOT_YET_RECRUITING","sponsor":"University Of Perugia","startDate":"2024-06-01","conditions":["Abnormal Uterine Bleeding"],"enrollment":20,"completionDate":"2025-07-01"},{"nctId":"NCT03059173","phase":"PHASE3","title":"Interest of Myo-inositol Supplementation in Women With Polycystic Ovarian Syndrome","status":"RECRUITING","sponsor":"University Hospital, Lille","startDate":"2023-09-12","conditions":["Polycystic Ovary Syndrome","Reproductive Medicine"],"enrollment":276,"completionDate":"2027-12"},{"nctId":"NCT06158932","phase":"NA","title":"A Single Group Study to Evaluate the Effects of a Myo-Inositol and D-Chiro Inositol Supplement on Symptoms Associated With Polycystic Ovary Syndrome and Hormone Imbalance","status":"COMPLETED","sponsor":"Optify","startDate":"2023-09-08","conditions":["Polycystic Ovary Syndrome","Hormone Imbalance"],"enrollment":40,"completionDate":"2024-01-06"},{"nctId":"NCT04892186","phase":"NA","title":"Effects of Myo-inositol in Women With Polycystic Ovary Syndrome","status":"COMPLETED","sponsor":"University of Sao Paulo General Hospital","startDate":"2021-03-26","conditions":["Polycystic Ovary Syndrome","Resistance, Insulin","Glucose Intolerance"],"enrollment":60,"completionDate":"2023-10-20"},{"nctId":"NCT06057896","phase":"","title":"Effects of Combined Natural Molecules on Metabolic Syndrome in Menopausal Women","status":"COMPLETED","sponsor":"Lo.Li.Pharma s.r.l","startDate":"2022-09-30","conditions":["Menopause","Climacteric Syndrome","Metabolic Syndrome"],"enrollment":200,"completionDate":"2023-08-15"},{"nctId":"NCT02811133","phase":"PHASE1,PHASE2","title":"Inositol for Comorbid Anxiety in Children and Adolescents With Bipolar Disorder","status":"WITHDRAWN","sponsor":"Ronald M. Glick, MD","startDate":"2023-08","conditions":["Bipolar Disorder","Anxiety Disorders","Anxiety"],"enrollment":0,"completionDate":"2023-10-04"},{"nctId":"NCT04860492","phase":"NA","title":"The Impact of Renalof® Dietary Supplement on Upper Urinary Tract Stone Volume","status":"COMPLETED","sponsor":"Aristotle University Of Thessaloniki","startDate":"2020-09-01","conditions":["Calculus of Upper Urinary Tract (Disorder)"],"enrollment":82,"completionDate":"2022-12-01"},{"nctId":"NCT01267604","phase":"PHASE4","title":"Ovarian Stimulation: Inositol and Melatonin","status":"WITHDRAWN","sponsor":"AGUNCO Obstetrics and Gynecology Centre","startDate":"2010-12","conditions":["Infertility"],"enrollment":0,"completionDate":""},{"nctId":"NCT01244399","phase":"","title":"Influence of \"Espresso\" on Adsorption of Myo-inositol","status":"COMPLETED","sponsor":"AGUNCO Obstetrics and Gynecology Centre","startDate":"2010-11","conditions":["Neural Tube Defects"],"enrollment":12,"completionDate":""},{"nctId":"NCT03177122","phase":"PHASE4","title":"Myo-Inositol- Based Co-treatment in Women With PCOS Undergoing Assisted Reproductive Technology","status":"UNKNOWN","sponsor":"American University of Beirut Medical Center","startDate":"2017-03-01","conditions":["Sterility","Infertility"],"enrollment":100,"completionDate":"2023-12-31"},{"nctId":"NCT05951309","phase":"NA","title":"Myoinositol Treatment and Asprosin Levels in PCOS","status":"COMPLETED","sponsor":"Near East University, Turkey","startDate":"2021-09-01","conditions":["PCOS","Insulin Resistance"],"enrollment":30,"completionDate":"2023-06-03"},{"nctId":"NCT05900661","phase":"PHASE2,PHASE3","title":"The Effect of Myo-inositol, Somatropin, and DHEA on Poor Ovarian Responders","status":"UNKNOWN","sponsor":"Beni-Suef University","startDate":"2023-07-30","conditions":["Poor Responders"],"enrollment":300,"completionDate":"2023-09-30"},{"nctId":"NCT05943158","phase":"NA","title":"Myoinositol Effect on Asprosin Levels","status":"COMPLETED","sponsor":"Near East University, Turkey","startDate":"2021-06-01","conditions":["Pregnancy Related"],"enrollment":40,"completionDate":"2023-06-15"},{"nctId":"NCT05117710","phase":"PHASE1","title":"IMPase in Treatment-resistant Depression","status":"UNKNOWN","sponsor":"University of Oxford","startDate":"2021-04-22","conditions":["Depressive Disorder, Treatment-Resistant"],"enrollment":50,"completionDate":"2024-05-31"},{"nctId":"NCT05128669","phase":"NA","title":"Child and Parent-directed Individualized Psychotherapy (CPIP)","status":"UNKNOWN","sponsor":"University of Leipzig","startDate":"2020-07-21","conditions":["Child Neglect","Internalizing Disorder"],"enrollment":200,"completionDate":"2025-03-20"},{"nctId":"NCT05678114","phase":"NA","title":"Inositol Treatment in Different Type of PCOS Phenotype","status":"COMPLETED","sponsor":"Lo.Li.Pharma s.r.l","startDate":"2022-12-21","conditions":["Polycystic Ovary Syndrome"],"enrollment":120,"completionDate":"2023-05-12"},{"nctId":"NCT02509988","phase":"NA","title":"Nutritional Intervention Preconception and During Pregnancy to Maintain Healthy Glucose Metabolism and Offspring Health","status":"COMPLETED","sponsor":"University of Southampton","startDate":"2015-07","conditions":["Hyperglycemia"],"enrollment":1729,"completionDate":"2022-06"},{"nctId":"NCT05855629","phase":"NA","title":"\"A Comparative Clinical Evaluation of the Efficacy of Topical Adapalene, Benzoyl Peroxide Gel, Oral Lactobacillus Rhamnosus, D-chiro-inositol, Inulin Capsule, and Their Fixed Combination in Mild to Moderate Acne Vulgaris Patients.\"","status":"UNKNOWN","sponsor":"Treatment and Diagnostic Center of Private Enterprise \"Asklepiy\"","startDate":"2022-02-18","conditions":["Acne Vulgaris"],"enrollment":59,"completionDate":"2023-07-30"},{"nctId":"NCT01875445","phase":"PHASE2","title":"Inositol in Trichotillomania","status":"COMPLETED","sponsor":"University of Chicago","startDate":"2013-05","conditions":["Trichotillomania","Hair Pulling"],"enrollment":38,"completionDate":"2016-05"},{"nctId":"NCT05701813","phase":"NA","title":"The Study Aims to Investigate the Effects of Oral Inositols on Insulin-resistance in Children With Obesity.","status":"UNKNOWN","sponsor":"Azienda Ospedaliera Universitaria Integrata Verona","startDate":"2023-02-01","conditions":["Obesity","Prediabetic State","Dyslipidemias","Insulin Resistance"],"enrollment":56,"completionDate":"2024-02-01"},{"nctId":"NCT05283642","phase":"NA","title":"D-chiro-inositol and Endometrial Thickness","status":"COMPLETED","sponsor":"Lo.Li.Pharma s.r.l","startDate":"2022-03-08","conditions":["Endometrial Diseases"],"enrollment":13,"completionDate":"2022-12-20"},{"nctId":"NCT04306692","phase":"PHASE4","title":"Myo-inositol Versus Clomiphene Citrate in PCOS","status":"TERMINATED","sponsor":"University Hospital, Ghent","startDate":"2020-07-02","conditions":["Ovulation Induction","Polycystic Ovary Syndrome","Clomiphene","Inositol"],"enrollment":12,"completionDate":"2022-01-31"},{"nctId":"NCT05586295","phase":"NA","title":"Vitamin B Complex Improved Exercise Performance and Anti-fatigue","status":"COMPLETED","sponsor":"National Taiwan Sport University","startDate":"2021-03-03","conditions":["Exercise Performance","Fatigue"],"enrollment":32,"completionDate":"2021-06-26"},{"nctId":"NCT05348304","phase":"NA","title":"Hypoglycemic Effects of a Dietary Supplement With Inositols, Gymnema Silvestre, Alpha-lactalbumin and Zinc.","status":"COMPLETED","sponsor":"Lo.Li.Pharma s.r.l","startDate":"2022-06-28","conditions":["Metabolism Disorder"],"enrollment":37,"completionDate":"2022-10-12"},{"nctId":"NCT05448378","phase":"NA","title":"Evaluation of D-chiro-inositol Treatments","status":"COMPLETED","sponsor":"Lo.Li.Pharma s.r.l","startDate":"2022-06-04","conditions":["Inositol","Testosterone","Insulin","Ovulation","Asprosin"],"enrollment":10,"completionDate":"2022-09-16"},{"nctId":"NCT05524259","phase":"NA","title":"MYPP-trial: Myo-inositol Supplementation to Prevent Pregnancy Complications in Women With Polycystic Ovary Syndrome.","status":"UNKNOWN","sponsor":"Erasmus Medical Center","startDate":"2019-06-21","conditions":["Gestational Diabetes Mellitus","Preeclampsia","Preterm Birth","Polycystic Ovary Syndrome"],"enrollment":464,"completionDate":"2024-02"},{"nctId":"NCT01828710","phase":"NA","title":"Myo-inositol on Human Semen Parameters","status":"COMPLETED","sponsor":"AGUNCO Obstetrics and Gynecology Centre","startDate":"2012-08","conditions":["Asthenozoospermia","Oligospermia"],"enrollment":62,"completionDate":"2012-11"},{"nctId":"NCT05333315","phase":"NA","title":"Clinical Trials of Five Different Food Supplements With Restriction Diet in Adults","status":"COMPLETED","sponsor":"University of Primorska","startDate":"2022-04-20","conditions":["Overweight and Obesity","Inflammation","Hypercholesterolemia","Hypertension"],"enrollment":120,"completionDate":"2022-07-15"},{"nctId":"NCT05419596","phase":"","title":"The Analysis of Gene Variants Related to POCD in Elderly Patients","status":"UNKNOWN","sponsor":"Istanbul University","startDate":"2022-07-01","conditions":["Cognitive Dysfunction"],"enrollment":126,"completionDate":"2023-07-25"},{"nctId":"NCT01030575","phase":"PHASE2","title":"Multi-dose Pharmacokinetics and Dose Ranging of Inositol in Premature Infants (INS-2)","status":"COMPLETED","sponsor":"NICHD Neonatal Research Network","startDate":"2010-01","conditions":["Infant, Newborn","Infant, Low Birth Weight","Infant, Small for Gestational Age","Infant, Premature","Retinopathy of Prematurity","Bronchopulmonary Dysplasia (BPD)"],"enrollment":125,"completionDate":"2013-09"},{"nctId":"NCT05410314","phase":"","title":"Nutritional Supplement Based on Myo-inositol-D-chiro-inositoln in Long-term Survivors of Lymphoma","status":"COMPLETED","sponsor":"University of Bari Aldo Moro","startDate":"2020-02-07","conditions":["Lymphoma, Hodgkin","Menstrual Irregularity","Fertility Disorders"],"enrollment":90,"completionDate":"2021-12-07"},{"nctId":"NCT04278053","phase":"NA","title":"Evaluation of Sports Supplements on Blood Flow","status":"COMPLETED","sponsor":"University of Arkansas, Fayetteville","startDate":"2018-10-15","conditions":["Determine the Effects of Nitrosigine and Citrulline-malate on Flow-mediated Dilation Among Young Adults"],"enrollment":24,"completionDate":"2019-05-08"},{"nctId":"NCT04890808","phase":"NA","title":"Therapeutic Antioxidant Supplementation","status":"NOT_YET_RECRUITING","sponsor":"Superficial Siderosis Research Alliance Inc.","startDate":"2023-05","conditions":["Superficial Siderosis"],"enrollment":50,"completionDate":"2027-09"},{"nctId":"NCT03677011","phase":"NA","title":"Andrositol® TEST as Diagnostic Assay to Predict the Fertilization Potential in IVF","status":"COMPLETED","sponsor":"Lo.Li.Pharma s.r.l","startDate":"2018-07-01","conditions":["Male Infertility"],"enrollment":249,"completionDate":"2021-10-31"},{"nctId":"NCT01246310","phase":"NA","title":"Myoinositol for the Treatment of Ovarian and Psychiatric Disorder in Polycystic Ovary Syndrome (PCOS) Patients","status":"TERMINATED","sponsor":"AGUNCO Obstetrics and Gynecology Centre","startDate":"2010-11","conditions":["Depression","PCOS"],"enrollment":24,"completionDate":"2022-02"},{"nctId":"NCT04238429","phase":"NA","title":"Whitening Efficacy of Dentifrice Containing 10% High Cleaning Silica, 0.5% Sodium Phytate and 0.5% Sodium Pyrophosphate","status":"COMPLETED","sponsor":"Sun Yat-sen University","startDate":"2018-05-07","conditions":["Tooth Bleaching"],"enrollment":86,"completionDate":"2018-10-05"},{"nctId":"NCT05130905","phase":"NA","title":"RiteStart Personal Nutritional Dietary Study","status":"COMPLETED","sponsor":"4Life Research, LLC","startDate":"2017-09-01","conditions":["Healthy Nutrition"],"enrollment":20,"completionDate":"2017-12-20"},{"nctId":"NCT02397291","phase":"NA","title":"Transplacental Gradients and Transport in Intrauterine Growth Restricted (IUGR) Pregnancies Compared to Normal Pregnancies.","status":"TERMINATED","sponsor":"University of Colorado, Denver","startDate":"2001-01","conditions":["IUGR","Pregnancy"],"enrollment":24,"completionDate":"2016-12"},{"nctId":"NCT00039741","phase":"PHASE2,PHASE3","title":"Anti-HIV Drug Regimens and Treatment-Switching Guidelines in HIV Infected Children","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2002-08","conditions":["HIV Infections"],"enrollment":266,"completionDate":"2010-03"},{"nctId":"NCT03598374","phase":"NA","title":"Spontaneous Reproductive Outcomes After Oral Inositol Supplementation in Infertile Polycystic Ovarian Syndrome Women.","status":"UNKNOWN","sponsor":"Università degli Studi dell'Insubria","startDate":"2022-01-01","conditions":["Polycystic Ovarian Syndrome","Infertility, Female"],"enrollment":80,"completionDate":"2024-12-31"},{"nctId":"NCT04867252","phase":"PHASE2","title":"Effects of Combined Resveratrol and Myo-inositol on Altered Metabolic, Endocrine Parameters and Perceived Stress in Patients With Polycystic Ovarian Syndrome","status":"COMPLETED","sponsor":"Khyber Medical University Peshawar","startDate":"2021-05-03","conditions":["PCOS"],"enrollment":88,"completionDate":"2021-08-03"},{"nctId":"NCT02050672","phase":"NA","title":"Effect of Myoinositol Treatment of Spermatozoa on in Vitro Fertilization Outcome","status":"COMPLETED","sponsor":"AGUNCO Obstetrics and Gynecology Centre","startDate":"2013-05","conditions":["Couple Sterility"],"enrollment":249,"completionDate":"2021-07"},{"nctId":"NCT04615767","phase":"NA","title":"D-chiro-inositol Increases Androgens and Reduces Estrogens in Human Serum","status":"COMPLETED","sponsor":"AGUNCO Obstetrics and Gynecology Centre","startDate":"2020-10-28","conditions":["Low Serum Testosterone Levels in Man"],"enrollment":10,"completionDate":"2020-12-16"},{"nctId":"NCT04291495","phase":"NA","title":"Evaluation of the Effects of Semen Incubation With ANDROSITOL®DGN on Sperm Motility and Mitochondrial Membrane Potential","status":"COMPLETED","sponsor":"University of Catania","startDate":"2018-10-23","conditions":["Asthenozoospermia","Mitochondrial Damage"],"enrollment":25,"completionDate":"2020-10-31"},{"nctId":"NCT04645745","phase":"NA","title":"Myo-inositol, Alpha-Lactalbumin and Folic Acid Treatment in PCOS","status":"COMPLETED","sponsor":"AGUNCO Obstetrics and Gynecology Centre","startDate":"2019-06-15","conditions":["Polycystic Ovary Syndrome"],"enrollment":36,"completionDate":"2020-02-28"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{"route":"Oral, Intramuscular","formulation":"Injection, Tablet","formulations":[{"form":"INJECTION","route":"INTRAMUSCULAR","productName":"Lipovite"},{"form":"INJECTION","route":"INTRAMUSCULAR","productName":"MIC B12"},{"form":"TABLET","route":"ORAL","productName":"NEONATAL PLUS VITAMIN"}]},"crossReferences":{"NUI":"N0000146062","MMSL":"4879","NDDF":"002057","UNII":"4L6452S749","VUID":"4017688","CHEBI":"CHEBI:17268","VANDF":"4017688","INN_ID":"10437","RXNORM":"5833","UMLSCUI":"C0021547","ChEMBL_ID":"CHEMBL1222251","KEGG_DRUG":"D08079","DRUGBANK_ID":"DB13178","PDB_CHEM_ID":" INS","PUBCHEM_CID":"892","SNOMEDCT_US":"108960004","MESH_DESCRIPTOR_UI":"D007294"},"formularyStatus":[],"_enricherVersion":"v2","_offLabelChecked":true,"developmentCodes":[],"ownershipHistory":[],"publicationCount":43037,"therapeuticAreas":["Metabolic"],"atcClassification":{"source":"DrugCentral","atcCode":"A11HA07","allCodes":["A11HA07"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"discontinued","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Inosital (INOSITOL) is a small molecule drug in the inositol class, originally developed by an unknown entity. It is currently owned by an unknown entity and has been approved for various indications including hypercholesterolemia, hypertriglyceridemia, and myocardial reinfarction prevention. The commercial status of Inosital is unknown, and it is not clear if it is patented or available as a generic. Key safety considerations are not well-documented. Inosital is used to treat conditions related to lipid metabolism.","enrichmentLevel":3,"visitCount":0,"regulatoryByCountry":[{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":"","brand_name_local":null,"application_number":""},{"country_code":"IL","regulator":"MOH","status":"likely_approved","approval_date":null,"mah":"","brand_name_local":null,"application_number":null},{"country_code":"SG","regulator":"HSA","status":"likely_approved","approval_date":null,"mah":"","brand_name_local":null,"application_number":null},{"country_code":"SA","regulator":"SFDA","status":"likely_approved","approval_date":null,"mah":"","brand_name_local":null,"application_number":null},{"country_code":"AE","regulator":"MOH","status":"likely_approved","approval_date":null,"mah":"","brand_name_local":null,"application_number":null},{"country_code":"KR","regulator":"MFDS","status":"likely_approved","approval_date":null,"mah":"","brand_name_local":null,"application_number":null},{"country_code":"CA","regulator":"Health Canada","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"AU","regulator":"TGA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"GB","regulator":"MHRA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":3,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}