{"id":"innohep","safety":{"commonSideEffects":[{"rate":null,"effect":"Bleeding"},{"rate":null,"effect":"Thrombocytopenia"},{"rate":null,"effect":"Injection site hematoma"},{"rate":null,"effect":"Elevated liver enzymes"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Innohep (tinzaparin sodium) is a low-molecular-weight heparin (LMWH) derived from porcine intestinal mucosa. It potentiates the inhibition of coagulation factors, particularly factor Xa and thrombin, through its interaction with antithrombin III. This prevents thrombus formation and is used for thromboprophylaxis and treatment of venous thromboembolism.","oneSentence":"Innohep is a low-molecular-weight heparin that inhibits blood coagulation by enhancing the activity of antithrombin III against factor Xa and thrombin.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:49:14.103Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prophylaxis of deep vein thrombosis (DVT) in patients undergoing general or orthopedic surgery"},{"name":"Treatment of acute deep vein thrombosis and pulmonary embolism"},{"name":"Prophylaxis of thromboembolism in patients with acute myocardial infarction"}]},"trialDetails":[{"nctId":"NCT00277394","phase":"PHASE4","title":"Innohep® in Elderly Patients With Impaired Renal Function Treated for Acute Deep Vein Thrombosis","status":"COMPLETED","sponsor":"LEO Pharma","startDate":"2005-12","conditions":"Deep Vein Thrombosis","enrollment":541},{"nctId":"NCT05284552","phase":"PHASE2","title":"Tinzaparin And Biomarkers After Neoadjuvant Treatment of Ovarian Cancer","status":"RECRUITING","sponsor":"University Hospital, Linkoeping","startDate":"2022-07-12","conditions":"Epithelial Ovarian Cancer","enrollment":40},{"nctId":"NCT01130025","phase":"PHASE3","title":"Long-Term Innohep® Treatment Versus a Vitamin K Antagonist (Warfarin) for the Treatment of Venous Thromboembolism (VTE) in Cancer","status":"COMPLETED","sponsor":"LEO Pharma","startDate":"2010-08","conditions":"Venous Thromboembolism","enrollment":900},{"nctId":"NCT02580773","phase":"PHASE3","title":"Therapeutic Anticoagulation Strategy for Acute Chest Syndrome","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2016-12-16","conditions":"Anemia, Sickle Cell, Acute Chest Syndrome","enrollment":198},{"nctId":"NCT05178628","phase":"PHASE3","title":"The Impact of Thromboprophylaxis on Progression Free Survival of Patients With Advanced Pancreatic Cancer","status":"UNKNOWN","sponsor":"Michalis Karamouzis","startDate":"2022-02-10","conditions":"Pancreatic Cancer, Thromboembolism","enrollment":450},{"nctId":"NCT04412291","phase":"PHASE2","title":"A Study in Patients With COVID-19 and Respiratory Distress Not Requiring Mechanical Ventilation, to Compare Standard-of-care With Anakinra and Tocilizumab Treatment The Immunomodulation-CoV Assessment (ImmCoVA) Study","status":"UNKNOWN","sponsor":"Karolinska University Hospital","startDate":"2020-06-11","conditions":"Covid-19","enrollment":120},{"nctId":"NCT04344756","phase":"PHASE2","title":"Trial Evaluating Efficacy and Safety of Anticoagulation in Patients With COVID-19 Infection, Nested in the Corimmuno-19 Cohort","status":"UNKNOWN","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2020-04-20","conditions":"COVID19 Pneumonia","enrollment":808},{"nctId":"NCT03099031","phase":"","title":"Non Interventional Study of the Validation of the Ottawa Score in Cancer Patients With Venous Thromboembolism (VTE)","status":"COMPLETED","sponsor":"LEO Pharma","startDate":"2015-05","conditions":"Venous Thromboembolism","enrollment":420},{"nctId":"NCT01817257","phase":"PHASE2","title":"Anticoagulation Length in Cancer Associated Thrombosis","status":"TERMINATED","sponsor":"Cardiff University","startDate":"2013-12","conditions":"Cancer, Thrombosis, Venous Thromboembolism","enrollment":2},{"nctId":"NCT03665376","phase":"NA","title":"Feasibility and Efficacy of Enhanced Recovery After Surgery (ERAS) on Length of Stay Among Laparotomy Patients at Mbarara Regional Referral Hospital","status":"COMPLETED","sponsor":"Mbarara University of Science and Technology","startDate":"2017-06-01","conditions":"Laparotomy","enrollment":33},{"nctId":"NCT01321788","phase":"","title":"Venous Thromboembolism Prophylaxis Post Cesarean Section","status":"UNKNOWN","sponsor":"King Saud University","startDate":"2011-01","conditions":"Bleeding, Venous Thromboembolism","enrollment":300},{"nctId":"NCT00711308","phase":"PHASE4","title":"Tinzaparin in the Treatment of the Acute Pulmonary Embolism","status":"COMPLETED","sponsor":"Complejo Hospitalario Xeral-Calde","startDate":"2005-04","conditions":"Acute Pulmonary Embolism","enrollment":102},{"nctId":"NCT00689520","phase":"PHASE4","title":"Long-Term Low-Molecular-Weight Heparin Versus Oral Anticoagulants in Deep Venous Thrombosis","status":"COMPLETED","sponsor":"Hospital Universitari de Bellvitge","startDate":"2002-01","conditions":"Venous Thromboembolism","enrollment":241}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":26,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Tinzaparin sodium","Tinzaparin"],"phase":"marketed","status":"active","brandName":"innohep®","genericName":"innohep®","companyName":"LEO Pharma","companyId":"leo-pharma","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Innohep is a low-molecular-weight heparin that inhibits blood coagulation by enhancing the activity of antithrombin III against factor Xa and thrombin. Used for Prophylaxis of deep vein thrombosis (DVT) in patients undergoing general or orthopedic surgery, Treatment of acute deep vein thrombosis and pulmonary embolism, Prophylaxis of thromboembolism in patients with acute myocardial infarction.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}