{"id":"injection-sclerotherapy","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site pain or discomfort"},{"rate":null,"effect":"Bruising or hematoma at injection site"},{"rate":null,"effect":"Hyperpigmentation or skin discoloration"},{"rate":null,"effect":"Allergic reaction"},{"rate":null,"effect":"Thrombophlebitis"}]},"_chembl":{"chemblId":"CHEMBL2108760","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The sclerosing agent (typically sodium tetradecyl sulfate, polidocanol, or similar) damages the endothelial lining of the target vessel, triggering an inflammatory response that leads to fibrosis and eventual closure. The vessel is then reabsorbed by the body or becomes a fibrous cord. This procedure is used to treat varicose veins, spider veins, and other vascular malformations by eliminating the abnormal vessel without surgical removal.","oneSentence":"Injection sclerotherapy works by injecting a sclerosing agent directly into abnormal blood vessels or varicose veins to cause inflammation, fibrosis, and obliteration of the vessel.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:16:15.941Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Varicose veins"},{"name":"Spider veins (telangiectasia)"},{"name":"Venous malformations"}]},"trialDetails":[{"nctId":"NCT07498010","phase":"PHASE2","title":"Doxycycline Use in Post-Operative Seromas","status":"NOT_YET_RECRUITING","sponsor":"University of Miami","startDate":"2026-05","conditions":"Seroma, Post Operative Seroma","enrollment":10},{"nctId":"NCT07199673","phase":"NA","title":"Comparison of Outcome of Injection Sclerotherapy Versus Rubber Band Ligation for Second Degree Hemorrhoids","status":"ACTIVE_NOT_RECRUITING","sponsor":"Gulab Devi Hospital","startDate":"2025-07-07","conditions":"Hemorrhoid","enrollment":128},{"nctId":"NCT07445425","phase":"NA","title":"Comparison of Radiofrequency Ablation With Concomitant or Staged Treatment for Tributary Varicose Veins","status":"NOT_YET_RECRUITING","sponsor":"Sir Run Run Shaw Hospital","startDate":"2026-03","conditions":"Varicose Veins of Lower Limb","enrollment":206},{"nctId":"NCT07024654","phase":"PHASE2","title":"Genicular Embolization Using Doxycycline Sclerotherapy","status":"WITHDRAWN","sponsor":"Campbell Clinic","startDate":"2026-06","conditions":"Chronic Knee Pain, Osteoarthritis","enrollment":""},{"nctId":"NCT07378657","phase":"PHASE3","title":"Systematic Approach for Children With Orbital Malformation With Sirolimus Use","status":"RECRUITING","sponsor":"Ain Shams University","startDate":"2025-11-01","conditions":"Orbital Lymphatic 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Method (Tessari Method) for Treating Lower Limb Varicose Veins","status":"COMPLETED","sponsor":"Lidiane Rocha","startDate":"2024-10-25","conditions":"Varicose Veins","enrollment":35},{"nctId":"NCT07173179","phase":"PHASE4","title":"Papillary Epinephrine Injection Combined With Rectal Indomethacin","status":"COMPLETED","sponsor":"Duzce University","startDate":"2022-07-01","conditions":"Post-ERCP Acute Pancreatitis","enrollment":504},{"nctId":"NCT07162844","phase":"NA","title":"Foam and Liquid Sclerotherapy With or Without Herbal Gel for Small Vein Treatment","status":"ACTIVE_NOT_RECRUITING","sponsor":"Kafrelsheikh University","startDate":"2024-09-05","conditions":"Telangectasia, Reticular Veins","enrollment":508},{"nctId":"NCT06943703","phase":"","title":"Bleomycin as an Effective and Curative Adjunct Therapy for Lymphangioma","status":"COMPLETED","sponsor":"National Children's Hospital, Vietnam","startDate":"2018-01-01","conditions":"Lymphangioma, Lymphatic 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Agent in the Treatment of Oral Granuloma","status":"NOT_YET_RECRUITING","sponsor":"Assiut University","startDate":"2024-10-15","conditions":"Pyogenic Granuloma of Gingiva","enrollment":20},{"nctId":"NCT06626802","phase":"NA","title":"Steroid Versus Mitomycin-C Use in Pediatric Benign Recurrent Esophageal Stricture","status":"COMPLETED","sponsor":"King Edward Medical University","startDate":"2023-07-01","conditions":"Esophageal Stricture","enrollment":24},{"nctId":"NCT06514079","phase":"NA","title":"Role of Topical Steroid Injection With Refractory Benign Esophageal Stricture Endoscopic Dilatation in Children","status":"RECRUITING","sponsor":"Mohammad Daboos","startDate":"2022-03-02","conditions":"Pediatric Disorder, Esophageal Diseases, Esophageal Stricture","enrollment":21},{"nctId":"NCT03416413","phase":"PHASE4","title":"Study of Foam Sclerotherapy Versus Ambulatory Phlebectomy","status":"RECRUITING","sponsor":"Imperial College London","startDate":"2018-02-01","conditions":"Varicose Veins","enrollment":160},{"nctId":"NCT06437158","phase":"PHASE2","title":"Use of Bleomycin in the Sclerotherapy of Lymphatic Malformations for Pediatric Patients","status":"RECRUITING","sponsor":"West China Hospital","startDate":"2023-03-08","conditions":"Lymphatic Malformation","enrollment":200},{"nctId":"NCT06399744","phase":"NA","title":"Role of Sclerotherapy in Treatment of Non-neoplastic Ovarian Cyst","status":"COMPLETED","sponsor":"Al-Azhar University","startDate":"2022-09-01","conditions":"Benign Ovarian Cyst","enrollment":52},{"nctId":"NCT06353230","phase":"NA","title":"Comparison of Sclerotherapy Agents Used for Rectal Prolapse Treatment in Children","status":"COMPLETED","sponsor":"King Edward Medical University","startDate":"2019-10-15","conditions":"Rectal Prolapse","enrollment":93},{"nctId":"NCT04867590","phase":"NA","title":"A Study Comparing the Effectiveness of EndoRotor Versus Radiofrequency in Treating Barrett's Esophagus","status":"RECRUITING","sponsor":"University Hospital, Angers","startDate":"2022-03-25","conditions":"Barrett Esophagus, Dysplasia","enrollment":140},{"nctId":"NCT04169152","phase":"","title":"CAES for Internal Hemorrhoids and Rectal Prolapse","status":"RECRUITING","sponsor":"Faming Zhang","startDate":"2019-12-30","conditions":"Internal Hemorrhoid, Rectal Prolapse","enrollment":10000},{"nctId":"NCT02851940","phase":"NA","title":"Pain and Bleeding Following Hypertonic Saline Sclerotherapy Compared to Brand Ligation for Symptomatic Hemorrhoids","status":"WITHDRAWN","sponsor":"American University of Beirut Medical Center","startDate":"2016-09","conditions":"Hemorrhoids, Bleeding, Pain","enrollment":""},{"nctId":"NCT01347294","phase":"PHASE4","title":"Compare Two Different Sclerosing Agents in the Treatment of Venous Malformations","status":"UNKNOWN","sponsor":"Oslo University Hospital","startDate":"2011-08","conditions":"Venous Malformation","enrollment":135},{"nctId":"NCT03674346","phase":"NA","title":"Efficacy of Hypnoanalgesia by a Radiologist Technologist in Children With Cutaneous Angioma Treated With Sclerosis in Interventional Radiology","status":"UNKNOWN","sponsor":"Hospices Civils de Lyon","startDate":"2024-01","conditions":"Angioma","enrollment":138},{"nctId":"NCT06080724","phase":"NA","title":"Efficacy of Intralesional Bleomycin Alone and in Combination With Dexamethasone in Infantile Haemangiomas","status":"COMPLETED","sponsor":"King Edward Medical University","startDate":"2021-03-22","conditions":"Comparison of Efficacy of Sclerotherapy in Infantile Hemangioma","enrollment":114},{"nctId":"NCT05696834","phase":"","title":"Sclerotherapy and Bone Marrow Injection In Aneurysmal Bone Cyst","status":"UNKNOWN","sponsor":"Al-Azhar University","startDate":"2023-03-01","conditions":"Orthopedic Disorder","enrollment":20},{"nctId":"NCT02627846","phase":"PHASE4","title":"Laser Ablation Versus Mechanochemical Ablation Trial","status":"COMPLETED","sponsor":"Hull University Teaching Hospitals NHS Trust","startDate":"2015-06-01","conditions":"Varicose Veins","enrollment":150},{"nctId":"NCT02335580","phase":"","title":"Effect of Portal Vein Thrombosis on the Prognosis of Liver Cirrhosis","status":"COMPLETED","sponsor":"General Hospital of Shenyang Military Region","startDate":"2014-12","conditions":"Liver Cirrhosis, Portal Vein, Venous Thrombosis","enrollment":475},{"nctId":"NCT05633277","phase":"NA","title":"Outcomes of Sclerotherapy of the Ulcer Bed Compared to a Combination of Ablation and Injections","status":"UNKNOWN","sponsor":"ProMedica Health System","startDate":"2020-09-30","conditions":"Venous Reflux, Venous Insufficiency, Venous Ulcer","enrollment":30},{"nctId":"NCT05470972","phase":"EARLY_PHASE1","title":"Relation Between Ethanol Sclerotherapy for Endometrioma Systemic Immune Milieu","status":"COMPLETED","sponsor":"Tanta University","startDate":"2020-05-21","conditions":"Endometriosis","enrollment":69},{"nctId":"NCT05468450","phase":"NA","title":"RCT Comparing EVLA Versus Polidocanol Foam in the Treatment of SSV Insufficiency","status":"COMPLETED","sponsor":"Societe Francaise de Phlebologie","startDate":"2015-07-01","conditions":"Varicose Veins of Lower Limb","enrollment":161},{"nctId":"NCT03705754","phase":"NA","title":"Carbon Black Tattoo in Colon Cancer","status":"UNKNOWN","sponsor":"Szeged University","startDate":"2019-02-06","conditions":"Endoscopic Tattoo of Suspected Colon Cancer","enrollment":100},{"nctId":"NCT05268575","phase":"NA","title":"A Study on the Endoscopic Treatments of Hemorrhoids","status":"UNKNOWN","sponsor":"Fangyu Wang","startDate":"2022-05-30","conditions":"Hemorrhoids","enrollment":285},{"nctId":"NCT05099081","phase":"NA","title":"Effectiveness of Diode Laser and Sclerotherapy in Treatment of Oral Pyogenic Granuloma","status":"COMPLETED","sponsor":"Alexandria University","startDate":"2020-12-04","conditions":"Pyogenic Granuloma of Gingiva","enrollment":20},{"nctId":"NCT05089500","phase":"NA","title":"The Two Treatment 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Oleate Intralesional Sclerotherapy","status":"COMPLETED","sponsor":"Suez Canal University","startDate":"2019-02-28","conditions":"Venous Malformation","enrollment":15},{"nctId":"NCT00442364","phase":"PHASE2","title":"Safety Study of Varisolve® Procedure for Treatment of Varicose Veins in Patients With Right-to-left Cardiac Shunt","status":"COMPLETED","sponsor":"Boston Scientific Corporation","startDate":"2007-03","conditions":"Varicose Veins","enrollment":60},{"nctId":"NCT03649113","phase":"PHASE1","title":"Percutaneous Sclerotherapy of Symptomatic Liver Hemangioma With Bleomycin","status":"COMPLETED","sponsor":"Tehran University of Medical Sciences","startDate":"2018-09-01","conditions":"Hemangioma Liver","enrollment":25},{"nctId":"NCT04091763","phase":"PHASE2","title":"Polidocanol Foam Versus Rubber Band Ligation in the Treatment of Hemorrhoidal Disease","status":"COMPLETED","sponsor":"Universidade do Porto","startDate":"2018-08-01","conditions":"Hemorrhoids, Internal","enrollment":120},{"nctId":"NCT01408732","phase":"PHASE1, PHASE2","title":"Office-sclerotherapy for Epistaxis Due to Hereditary Hemorrhagic Telangiectasia","status":"COMPLETED","sponsor":"University of Minnesota","startDate":"2011-02","conditions":"Epistaxis, Hereditary Hemorrhagic Telangiectasia","enrollment":18},{"nctId":"NCT03733171","phase":"NA","title":"Platelet Rich Plasma in Bleeding Peptic Ulcer","status":"UNKNOWN","sponsor":"Zagazig University","startDate":"2018-09-20","conditions":"Bleeding Ulcer","enrollment":80},{"nctId":"NCT03388125","phase":"PHASE3","title":"Endoscopic Injection Sclerotherapy Versus N-butyl-2-cyanoacrylate Injection","status":"UNKNOWN","sponsor":"Sherief Abd-Elsalam","startDate":"2016-01-01","conditions":"Bleeding Esophageal Varices","enrollment":113},{"nctId":"NCT02646202","phase":"PHASE3","title":"Scleroligation for Eradication of Gastroesophageal Varices.","status":"UNKNOWN","sponsor":"Sherief Abd-Elsalam","startDate":"2015-01","conditions":"Gastroesophageal Varices","enrollment":90},{"nctId":"NCT02883023","phase":"PHASE2","title":"Electrosclerotherapy for Capillary Malformations","status":"UNKNOWN","sponsor":"Sophie Horbach","startDate":"2016-11","conditions":"Capillary Malformations, Vascular Malformations","enrollment":20},{"nctId":"NCT02361593","phase":"NA","title":"Transparent Cap-assisted Endoscopic Sclerotherapy","status":"COMPLETED","sponsor":"Shanghai Zhongshan Hospital","startDate":"2015-04","conditions":"Esophageal Varices","enrollment":120},{"nctId":"NCT02135627","phase":"NA","title":"TC-325 (HEMOSPRAY™) VS. CURRENT STANDARD OF CARE IN MANAGING MALIGNANT GASTROINTESTINAL BLEEDING: A PILOT STUDY TO INFORM A RANDOMIZED CONTROLLED TRIAL.","status":"COMPLETED","sponsor":"McGill University Health Centre/Research Institute of the McGill University Health Centre","startDate":"2014-04","conditions":"MALIGNANT GASTROINTESTINAL BLEEDING","enrollment":20},{"nctId":"NCT02048319","phase":"PHASE3","title":"Efficacy of Combining Pasireotide With Aspiration Sclerotherapy to Improve Volume Reduction of Hepatic Cysts","status":"COMPLETED","sponsor":"Radboud University Medical Center","startDate":"2013-12","conditions":"Symptomatic Dominant Liver Cyst","enrollment":34},{"nctId":"NCT01298908","phase":"NA","title":"Comparison of Treatments in Venous Insufficiency","status":"COMPLETED","sponsor":"Helsinki University Central Hospital","startDate":"2007-10","conditions":"Venous Insufficiency","enrollment":231},{"nctId":"NCT00010452","phase":"PHASE2, PHASE3","title":"Study of Picibanil (OK432) Sclerotherapy in Children With Macrocystic Lymphatic Malformations","status":"COMPLETED","sponsor":"University of Iowa","startDate":"2000-04","conditions":"Lymphatic Malformations","enrollment":150},{"nctId":"NCT02330731","phase":"NA","title":"N-butyl-2-cyanoacrylate, Iso-amyl-2-cyanoacrylate and Hypertonic Glucose With 72% Chromated Glycerin in Gastric Varices","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2012-01","conditions":"Gastric Varices","enrollment":90},{"nctId":"NCT01131962","phase":"PHASE3","title":"Comparing Two Methods to Stop Vomiting of Blood Using the Endoscope","status":"COMPLETED","sponsor":"University of Alexandria","startDate":"2008-05","conditions":"Hematemesis, Portal Hypertension","enrollment":200},{"nctId":"NCT01471496","phase":"NA","title":"Prophylactic Injection Therapy Reduces Recurrent Bleeding In Forrest Type IIb Duodenal Ulcers","status":"COMPLETED","sponsor":"Bakirkoy Dr. Sadi Konuk Research and Training Hospital","startDate":"2003-01","conditions":"Duodenal Ulcer Bleeding","enrollment":80},{"nctId":"NCT00835939","phase":"PHASE2, PHASE3","title":"Treatment for Achilles Tendinopathy","status":"UNKNOWN","sponsor":"University of Calgary","startDate":"2007-09","conditions":"Achilles Tendinopathy, Achilles Tendon Enthesopathy, Mid-Portion Achilles Tendinopathy","enrollment":17},{"nctId":"NCT00799851","phase":"PHASE4","title":"A Randomized Controlled Trial Comparing Band Ligation and Cyanoacrylate Injection for Esophageal Varices","status":"COMPLETED","sponsor":"Federal University of São Paulo","startDate":"2004-11","conditions":"Liver Disease","enrollment":38}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1148,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["5% ethanolamine oleate","Sotradecol"],"phase":"phase_3","status":"active","brandName":"Injection Sclerotherapy","genericName":"Injection Sclerotherapy","companyName":"Gulab Devi Hospital","companyId":"gulab-devi-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Injection sclerotherapy works by injecting a sclerosing agent directly into abnormal blood vessels or varicose veins to cause inflammation, fibrosis, and obliteration of the vessel. Used for Varicose veins, Spider veins (telangiectasia), Venous malformations.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}