{"id":"injection-of-hyaluronic-acid","safety":{"commonSideEffects":[{"rate":"5–15","effect":"Injection site pain or swelling"},{"rate":"5–10","effect":"Transient joint effusion"},{"rate":"2–5","effect":"Local warmth or erythema"},{"rate":"<1","effect":"Allergic reaction"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Hyaluronic acid is a naturally occurring glycosaminoglycan that mimics the properties of synovial fluid, providing lubrication and shock absorption in joints. 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Papilla Loss","enrollment":13},{"nctId":"NCT07266714","phase":"NA","title":"Ultrasound-guided vs Conventional Intraarticular Injection of Hyaluronic Acid for Management of Temporomandibular Joint Internal Derangement","status":"COMPLETED","sponsor":"Muhannad","startDate":"2024-09-01","conditions":"Anterior Disk Displacement TMJ","enrollment":40},{"nctId":"NCT07265778","phase":"NA","title":"Clinical Investigation for Evaluating the Safety and Efficacy of JTM102 to Mid Face Volume Deficiency","status":"ACTIVE_NOT_RECRUITING","sponsor":"Jetema Co., Ltd.","startDate":"2024-10-22","conditions":"Mid Face Volume Deficit","enrollment":149},{"nctId":"NCT07265791","phase":"NA","title":"Study of JTM104 Injection vs. Juvederm in Treating Moderate to Severe Nasolabial Folds","status":"NOT_YET_RECRUITING","sponsor":"Jetema Co., Ltd.","startDate":"2026-01-03","conditions":"Nasolabial Folds, Wrinkles","enrollment":100},{"nctId":"NCT04146194","phase":"","title":"OTTAPE : Observatory on the Use of New Therapies (LED Photobiomodulation, Radiofrequency, Laser and Injectable Hyaluronic Acid) in the Treatment of Women's Pelvic-perineal Pathologies After Failure, Partial or Total, of First-line Medical Treatment","status":"COMPLETED","sponsor":"Centre Hospitalier Universitaire de Nīmes","startDate":"2019-12-30","conditions":"Pelvic-perineal Pathology","enrollment":173},{"nctId":"NCT07178119","phase":"NA","title":"Bridging Technique Validation for Nasolabial Folds JN-BRIDGE-1","status":"RECRUITING","sponsor":"Dr. Joseph M Novoa Libermann","startDate":"2025-11-22","conditions":"Nasolabial Fold Correction, Facial Aging, Skin Rejuvenation","enrollment":60},{"nctId":"NCT04937998","phase":"NA","title":"PRP Versus HA IN OSTEOARTHRITIS OF THE PATELLOFEMORAL JOINT","status":"RECRUITING","sponsor":"Istituto Ortopedico Rizzoli","startDate":"2022-10-26","conditions":"Patellofemoral Osteoarthritis","enrollment":166},{"nctId":"NCT07121556","phase":"NA","title":"Treatment of Symptomatic Bilateral Knee 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Intra-mucosal Injections of Cross-linked Hyaluronic Acid (DESIRIAL®) in the Vaginal Vestibule","status":"COMPLETED","sponsor":"Centre Hospitalier Universitaire de Nīmes","startDate":"2017-06-19","conditions":"Menopause, Dyspareunia","enrollment":20},{"nctId":"NCT07237711","phase":"NA","title":"Clinical Investigation of Sensovisc","status":"NOT_YET_RECRUITING","sponsor":"Ankara City Hospital Bilkent","startDate":"2025-11-25","conditions":"Osteo Arthritis of the Knee","enrollment":75},{"nctId":"NCT03955315","phase":"PHASE1","title":"Study to Evaluate the Safety and Preliminary Efficacy of IDCT, a Treatment for Symptomatic Lumbar Disc Degeneration","status":"COMPLETED","sponsor":"DiscGenics, Inc.","startDate":"2019-05-23","conditions":"Degenerative Disc Disease","enrollment":38},{"nctId":"NCT07236632","phase":"NA","title":"Hyaluronic Acid vs Botulinum Toxin Injection in Treatment of Lifelong Drug-Resistant Premature Ejaculation: Randomized Study","status":"NOT_YET_RECRUITING","sponsor":"Benha University","startDate":"2025-12-15","conditions":"Premature Ejaculation","enrollment":80},{"nctId":"NCT07232199","phase":"NA","title":"Clinical Investigation of Sensovisc Sterile Sodium Hyaluronate Gel","status":"NOT_YET_RECRUITING","sponsor":"Ankara City Hospital Bilkent","startDate":"2025-11-25","conditions":"Osteoarthritis","enrollment":25},{"nctId":"NCT06074302","phase":"NA","title":"Hyaluronic Filler for Improvement of Radial Cheek Lines","status":"COMPLETED","sponsor":"Main Line Center for Laser Surgery","startDate":"2023-11-01","conditions":"Aging","enrollment":20},{"nctId":"NCT07219654","phase":"PHASE2","title":"Efficacy and Safety Study of TPX-115 on Partial-thickness Rotator Cuff Tear","status":"NOT_YET_RECRUITING","sponsor":"Tego Science, Inc.","startDate":"2025-11","conditions":"Partial Thickness Rotator Cuff Tears","enrollment":60},{"nctId":"NCT06653985","phase":"NA","title":"Intra-articular Corticosteroid With Hyaluronic Acid Plus Physiotherapy for Hip Pathologies (NON-OP HIP)","status":"RECRUITING","sponsor":"ArthroBiologix Inc.","startDate":"2024-05-01","conditions":"Osteoarthritis, Femoroacetabular Impingement Syndrome, Labrum Injury of the Hip Joint","enrollment":100},{"nctId":"NCT07204691","phase":"NA","title":"A Study to Evaluate the Safety and Performance of Dr Korman Laboratories' Hyaluronic Acid Filler 20 mg/mL With Lidocaine for Lip Augmentation","status":"NOT_YET_RECRUITING","sponsor":"Dr. Korman Laboratories Ltd.","startDate":"2025-09-24","conditions":"Lip Augmentation","enrollment":75},{"nctId":"NCT07193199","phase":"NA","title":"New Technique and Product for Chin Enhancement","status":"ACTIVE_NOT_RECRUITING","sponsor":"Erevna Innovations Inc.","startDate":"2025-06-02","conditions":"Aesthetic","enrollment":21},{"nctId":"NCT07183436","phase":"PHASE3","title":"Intra-articular Corticosteroids Are Widely Used for Adhesive Capsulitis, But Alternatives Are Required for Patients With 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Hyaluronic Acid (HA) and Ketorolac Have Shown Individual Benefits. 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