{"id":"injected-bupivacaine-intraperitoneally","safety":{"commonSideEffects":[{"rate":null,"effect":"Systemic toxicity (if absorbed in high concentrations)"},{"rate":null,"effect":"Peritoneal irritation"},{"rate":null,"effect":"Transient abdominal discomfort"}]},"_chembl":{"chemblId":"CHEMBL1098","moleculeType":"Small molecule","molecularWeight":"288.44"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Bupivacaine is a long-acting local anesthetic that penetrates nerve cell membranes and reversibly inhibits sodium influx, preventing depolarization and action potential propagation. When administered intraperitoneally, it anesthetizes visceral and parietal peritoneal nerves, reducing pain signaling from abdominal organs and tissues. This approach aims to provide sustained postoperative analgesia and reduce opioid requirements following abdominal surgery.","oneSentence":"Bupivacaine injected intraperitoneally blocks sodium channels in nerve fibers within the peritoneal cavity, providing local anesthesia and analgesia to abdominal tissues.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:16:13.892Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Postoperative pain management following abdominal surgery"}]},"trialDetails":[{"nctId":"NCT05755815","phase":"NA","title":"Retrolaminar Block Versus Intraperitoneal Block for Laparoscopic Cholecystectomy","status":"COMPLETED","sponsor":"Mansoura University","startDate":"2023-05-21","conditions":"Laparoscopic Cholecystectomy","enrollment":60},{"nctId":"NCT06046105","phase":"PHASE2, PHASE3","title":"Efficacy of Adding Dexmedetomidine Versus Ibuprofen as an Adjuvant to Intraperitoneal Bupivacaine for Pain Control After Laparoscopic Gynecological Procedures","status":"UNKNOWN","sponsor":"Ain Shams University","startDate":"2023-09-15","conditions":"Postoperative Pain, Acute","enrollment":180},{"nctId":"NCT00180687","phase":"PHASE3","title":"Clinical Trial of the Use of Intraperitoneal Local Anaesthetic","status":"COMPLETED","sponsor":"Imperial College London","startDate":"2004-10","conditions":"Pain, Postoperative","enrollment":80}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":47,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Marcaine"],"phase":"phase_3","status":"active","brandName":"Injected Bupivacaine intraperitoneally","genericName":"Injected Bupivacaine intraperitoneally","companyName":"Imperial College London","companyId":"imperial-college-london","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Bupivacaine injected intraperitoneally blocks sodium channels in nerve fibers within the peritoneal cavity, providing local anesthesia and analgesia to abdominal tissues. Used for Postoperative pain management following abdominal surgery.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}