{"id":"injectable-ms-dmt","safety":{"commonSideEffects":[{"rate":"40-90","effect":"Injection site reactions"},{"rate":"30-60","effect":"Flu-like symptoms"},{"rate":"20-40","effect":"Headache"},{"rate":"10-30","effect":"Fever"},{"rate":"10-25","effect":"Myalgia"},{"rate":"5-15","effect":"Depression"},{"rate":"5-10","effect":"Liver enzyme elevation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Biogen's injectable MS DMTs include agents such as interferon beta and glatiramer acetate, which modulate immune responses to reduce inflammatory attacks on the central nervous system. These therapies decrease the frequency and severity of relapses and slow the accumulation of disability in relapsing-remitting multiple sclerosis. The exact mechanisms vary by specific agent but generally involve shifting immune responses away from pro-inflammatory Th1/Th17 cells toward anti-inflammatory Th2 responses.","oneSentence":"Injectable MS DMT refers to disease-modifying therapies for multiple sclerosis administered by injection that work through various immunomodulatory mechanisms to reduce inflammation and slow disease progression.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:40:43.109Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Relapsing-remitting multiple sclerosis"},{"name":"Clinically isolated syndrome with MRI features consistent with MS"}]},"trialDetails":[{"nctId":"NCT04788615","phase":"PHASE3","title":"Open Label Randomized Multicenter to Assess Efficacy & Tolerability of Ofatumumab 20mg vs. First Line DMT in RMS","status":"COMPLETED","sponsor":"Novartis Pharmaceuticals","startDate":"2021-07-23","conditions":"Multiple Sclerosis","enrollment":185},{"nctId":"NCT06711354","phase":"","title":"B-cell Depletion in Offspring to Women With MS Under Immunomodulatory Treatment","status":"NOT_YET_RECRUITING","sponsor":"Region Stockholm","startDate":"2025-06","conditions":"Multiple Sclerosis, B-Cell Deficiency, Offspring, Adult","enrollment":111},{"nctId":"NCT06644638","phase":"","title":"Real-World Persistence and Adherence of Ofatumumab Compared to Self-Injectable and Oral DMTs in Patients With Multiple Sclerosis","status":"COMPLETED","sponsor":"Novartis","startDate":"2023-02-15","conditions":"Multiple Sclerosis","enrollment":3632},{"nctId":"NCT02471560","phase":"PHASE4","title":"Tecfidera and the Gut Microbiota","status":"COMPLETED","sponsor":"Biogen","startDate":"2015-11-06","conditions":"Multiple Sclerosis, Relapsing-Remitting","enrollment":36},{"nctId":"NCT03308994","phase":"","title":"Impact of the Arrival on the French Market of New First Line Oral Treatments on the Delay Between MS Onset and First Disease Modifying Treatment (DMTs) Administration","status":"COMPLETED","sponsor":"University Hospital, Caen","startDate":"2017-11-01","conditions":"C10.114.375.500","enrollment":650}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":4,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"injectable MS DMT","genericName":"injectable MS DMT","companyName":"Biogen","companyId":"biogen","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Injectable MS DMT refers to disease-modifying therapies for multiple sclerosis administered by injection that work through various immunomodulatory mechanisms to reduce inflammation and slow disease progression. Used for Relapsing-remitting multiple sclerosis, Clinically isolated syndrome with MRI features consistent with MS.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}