{"id":"inj-cisplatin","safety":{"commonSideEffects":[{"rate":"28-36%","effect":"Nephrotoxicity"},{"rate":"25-30%","effect":"Ototoxicity"},{"rate":"76-99%","effect":"Nausea and vomiting"},{"rate":"25-35%","effect":"Myelosuppression (thrombocytopenia)"},{"rate":"25-35%","effect":"Myelosuppression (leukopenia)"},{"rate":"10-20%","effect":"Peripheral neuropathy"},{"rate":"20-25%","effect":"Anemia"},{"rate":"29-47%","effect":"Electrolyte abnormalities (hypomagnesemia)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Cisplatin binds to DNA and forms intrastrand and interstrand crosslinks, which distort the DNA helix and block replication and transcription machinery. This leads to cell cycle arrest and apoptosis in rapidly dividing cancer cells. It is non-cell-cycle specific and effective against a broad range of malignancies.","oneSentence":"Cisplatin is a platinum-based chemotherapy agent that forms DNA crosslinks, preventing DNA replication and transcription in cancer cells.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:16:16.160Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Metastatic testicular cancer"},{"name":"Metastatic ovarian cancer"},{"name":"Advanced bladder cancer"},{"name":"Head and neck cancer"},{"name":"Non-small cell lung cancer"},{"name":"Small cell lung cancer"}]},"trialDetails":[{"nctId":"NCT00193739","phase":"PHASE3","title":"Neoadjuvant Chemotherapy Followed by Surgery Versus Concurrent Chemoradiation in Carcinoma of the Cervix","status":"UNKNOWN","sponsor":"Tata Memorial Hospital","startDate":"2003-09-04","conditions":"Cancer of Cervix","enrollment":635}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":4,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Inj.Cisplatin","genericName":"Inj.Cisplatin","companyName":"Tata Memorial Hospital","companyId":"tata-memorial-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Cisplatin is a platinum-based chemotherapy agent that forms DNA crosslinks, preventing DNA replication and transcription in cancer cells. Used for Metastatic testicular cancer, Metastatic ovarian cancer, Advanced bladder cancer.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}