{"id":"inhaled-reduced-glutathione","safety":{"commonSideEffects":[{"rate":null,"effect":"Cough"},{"rate":null,"effect":"Bronchospasm"},{"rate":null,"effect":"Throat irritation"},{"rate":null,"effect":"Nausea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Glutathione is a tripeptide antioxidant that plays a critical role in protecting cells from oxidative damage and maintaining redox balance. When inhaled directly, reduced glutathione can increase local glutathione concentrations in respiratory epithelial cells and airway secretions, enhancing antioxidant defenses and potentially improving mucociliary clearance. This mechanism may be particularly beneficial in conditions characterized by oxidative stress and impaired lung function.","oneSentence":"Inhaled reduced glutathione acts as an antioxidant and mucolytic agent that replenishes intracellular glutathione levels and reduces oxidative stress in the lungs.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:48:31.034Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cystic fibrosis (likely primary indication)"},{"name":"Idiopathic pulmonary fibrosis or other chronic lung diseases with oxidative stress"}]},"trialDetails":[{"nctId":"NCT05654922","phase":"PHASE3","title":"Study to Evaluate ARINA-1 in the Prevention of Bronchiolitis Obliterans Progression in Participants With Bilateral Lung Transplant","status":"RECRUITING","sponsor":"Renovion, Inc.","startDate":"2023-04-10","conditions":"Pre-Bronchiolitis Obliterans Syndrome","enrollment":100},{"nctId":"NCT05495243","phase":"PHASE2","title":"Phase 2a, 28-day Investigational Use Study of ARINA-1 in Non-Cystic Fibrosis Bronchiectasis (NCFBE) With Excess Mucus and Cough","status":"COMPLETED","sponsor":"Renovion, Inc.","startDate":"2022-10-03","conditions":"Non-cystic Fibrosis Bronchiectasis","enrollment":40},{"nctId":"NCT03368560","phase":"PHASE1","title":"A Breathing-Based Meditation Intervention for Patients With Treatment Resistant Late Life Depression","status":"WITHDRAWN","sponsor":"London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's","startDate":"2020-01-01","conditions":"Late Life Depression","enrollment":""},{"nctId":"NCT00506688","phase":"PHASE2","title":"Efficacy and Safety Study of Inhaled Glutathione in Cystic Fibrosis Patients","status":"COMPLETED","sponsor":"Mukoviszidose Institut gGmbH","startDate":"2007-07","conditions":"Cystic Fibrosis","enrollment":153},{"nctId":"NCT01450267","phase":"PHASE3","title":"Inhaled Glutathione (GSH) Versus Placebo in Cystic Fibrosis","status":"UNKNOWN","sponsor":"Serafino A. Marsico","startDate":"2010-06","conditions":"Cystic Fibrosis","enrollment":150},{"nctId":"NCT00263367","phase":"NA","title":"Effect of Hyperbaric Therapy on Markers of Oxidative Stress in Children With Autism","status":"COMPLETED","sponsor":"The International Child Development Resource Center","startDate":"2005-10","conditions":"Autism, Oxidative Stress","enrollment":10}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":188,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["GSH"],"phase":"phase_3","status":"active","brandName":"Inhaled Reduced Glutathione","genericName":"Inhaled Reduced Glutathione","companyName":"Serafino A. Marsico","companyId":"serafino-a-marsico","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Inhaled reduced glutathione acts as an antioxidant and mucolytic agent that replenishes intracellular glutathione levels and reduces oxidative stress in the lungs. Used for Cystic fibrosis (likely primary indication), Idiopathic pulmonary fibrosis or other chronic lung diseases with oxidative stress.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}