{"id":"inhaled-nitric-oxide-ino-use","safety":{"commonSideEffects":[{"rate":null,"effect":"Methemoglobinemia"},{"rate":null,"effect":"Rebound pulmonary hypertension upon withdrawal"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Tachycardia"}]},"_chembl":{"chemblId":"CHEMBL1200689","moleculeType":"Small molecule","molecularWeight":"30.01"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Nitric oxide (NO) is an endogenous signaling molecule that activates guanylate cyclase in vascular smooth muscle cells, increasing cyclic GMP levels and causing vasodilation. When inhaled, NO preferentially dilates pulmonary vessels while being rapidly inactivated by hemoglobin in the systemic circulation, allowing selective pulmonary vasodilation without systemic hypotension. This reduces right ventricular afterload and improves ventilation-perfusion matching in the lungs.","oneSentence":"Inhaled nitric oxide is a vasodilator gas that selectively relaxes pulmonary vascular smooth muscle to reduce pulmonary hypertension and improve oxygenation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:33:18.744Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Persistent pulmonary hypertension of the newborn (PPHN)"},{"name":"Acute respiratory distress syndrome (ARDS) with pulmonary hypertension"},{"name":"Pulmonary hypertension associated with left heart disease"},{"name":"Pulmonary hypertension associated with lung disease and hypoxemia"}]},"trialDetails":[{"nctId":"NCT04996667","phase":"PHASE2","title":"Effect of iNO in Patients With Submassive and Massive PE","status":"WITHDRAWN","sponsor":"University of California, Los Angeles","startDate":"2026-06-01","conditions":"Pulmonary Embolism, Pulmonary Embolism Subacute Massive","enrollment":""},{"nctId":"NCT05213676","phase":"PHASE4","title":"De-implementing Inhaled Nitric Oxide for Congenital Diaphragmatic Hernia","status":"RECRUITING","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2025-11-01","conditions":"Congenital Diaphragmatic Hernia","enrollment":600},{"nctId":"NCT07247240","phase":"PHASE4","title":"Efficacy of Inhaled Nitric Oxide in Congenital Diaphragmatic Hernia","status":"NOT_YET_RECRUITING","sponsor":"Asan Medical Center","startDate":"2025-11","conditions":"Congenital Diaphragmatic Hernia, Pulmonary Hypertension","enrollment":40},{"nctId":"NCT06702553","phase":"PHASE3","title":"Nitric Oxide for Reduced Intensive Support in Cardiac Surgery With Cardiopulmonary Bypass","status":"RECRUITING","sponsor":"Xijing Hospital","startDate":"2025-05-19","conditions":"Nitric Oxide, Cardiac Surgery, Cardiopulmonary Bypass","enrollment":3650},{"nctId":"NCT05896800","phase":"NA","title":"A Clinical Study of Inhaled Nitric Oxide in Moderate-to-Severe Chronic Obstructive Pulmonary Disease","status":"RECRUITING","sponsor":"The First Affiliated Hospital with Nanjing Medical University","startDate":"2023-06-01","conditions":"Chronic Obstructive Pulmonary Disease","enrollment":24},{"nctId":"NCT05868109","phase":"PHASE2","title":"Inhaled Nitric Oxide for Cardiac Arrest in Pediatrics and Adults (iNOCAPA)","status":"UNKNOWN","sponsor":"The Hospital for Sick Children","startDate":"2022-08-31","conditions":"Cardiac Arrest","enrollment":40},{"nctId":"NCT00945529","phase":"PHASE2, PHASE3","title":"The Effects of Inhaled Nitric Oxide After Fontan Operation","status":"COMPLETED","sponsor":"Ellen Spurrier","startDate":"2008-02","conditions":"Congenital Heart Defect","enrollment":21},{"nctId":"NCT03602781","phase":"PHASE3","title":"Study of PAH Subjects With LTOT Use That Have Demonstrated Improved Exercise Tolerance With the Use of Inhaled Nitric","status":"WITHDRAWN","sponsor":"Bellerophon Pulse Technologies","startDate":"2018-08","conditions":"Pulmonary Arterial Hypertension","enrollment":""},{"nctId":"NCT03079102","phase":"PHASE2","title":"Inhaled Nitric Oxide After Out-of-Hospital Cardiac Arrest","status":"TERMINATED","sponsor":"Cameron Dezfulian","startDate":"2017-08-26","conditions":"Heart Arrest, Out-Of-Hospital","enrollment":57},{"nctId":"NCT04383002","phase":"PHASE1","title":"High Dose Inhaled Nitric Oxide for COVID-19 (ICU Patients)","status":"COMPLETED","sponsor":"University Health Network, Toronto","startDate":"2020-09-02","conditions":"COVID-19","enrollment":21},{"nctId":"NCT00094887","phase":"PHASE2","title":"Nitric Oxide Inhalation to Treat Sickle Cell Pain Crises","status":"COMPLETED","sponsor":"Mallinckrodt","startDate":"2004-10","conditions":"Anemia, Sickle Cell","enrollment":150},{"nctId":"NCT01891500","phase":"PHASE4","title":"Early iNO for Oxidative Stress, Vascular Tone and Inflammation in Babies With Hypoxic Respiratory Failure","status":"WITHDRAWN","sponsor":"University of Florida","startDate":"2016-05","conditions":"Persistent Fetal Circulation Syndrome, Hypertension, Pulmonary, of Newborn, Persistent, Persistent Pulmonary Hypertension of Newborn","enrollment":""},{"nctId":"NCT00931632","phase":"PHASE3","title":"Inhaled Nitric Oxide (INO) for the Prevention of Bronchopulmonary Dysplasia (BPD) in Preterm Infants","status":"COMPLETED","sponsor":"Mallinckrodt","startDate":"2009-11","conditions":"Bronchopulmonary Dysplasia","enrollment":451},{"nctId":"NCT01717209","phase":"PHASE4","title":"Inhaled Nitric Oxide and Inhaled Prostacyclin After Cardiac Surgery for Heart Transplant or LVAD Placement","status":"COMPLETED","sponsor":"Stanford University","startDate":"2012-10","conditions":"Heart Failure","enrollment":14},{"nctId":"NCT00005773","phase":"PHASE3","title":"Early Inhaled Nitric Oxide for Respiratory Failure in Newborns","status":"TERMINATED","sponsor":"NICHD Neonatal Research Network","startDate":"1998-08","conditions":"Infant, Newborn, Hypertension, Pulmonary, Persistent Fetal Circulation Syndrome","enrollment":302},{"nctId":"NCT01748045","phase":"PHASE2, PHASE3","title":"Study of Inhaled Nitric Oxide (iNO) and Respiratory Outcomes in Late Preterm Infants","status":"TERMINATED","sponsor":"Tufts Medical Center","startDate":"2013-03","conditions":"Bronchopulmonary Dysplasia","enrollment":3},{"nctId":"NCT00955487","phase":"PHASE2","title":"Examining the Use of Non-Invasive Inhaled Nitric Oxide to Reduce Chronic Lung Disease in Premature Newborns","status":"COMPLETED","sponsor":"University of Colorado, Denver","startDate":"2007-01","conditions":"Bronchopulmonary Dysplasia","enrollment":124},{"nctId":"NCT00922532","phase":"PHASE3","title":"Inhaled Nitric Oxide (INO) In Hypoxic Respiratory Failure","status":"WITHDRAWN","sponsor":"Mallinckrodt","startDate":"2009-11","conditions":"Hypoxic Respiratory Failure With Pulmonary Hypertension","enrollment":""},{"nctId":"NCT00060840","phase":"PHASE2","title":"The Effects of Nitric Oxide for Inhalation During Left Ventricular Assists Device (LVAD) Implantation","status":"COMPLETED","sponsor":"Mallinckrodt","startDate":"2003-07","conditions":"Congestive Heart Failure","enrollment":150},{"nctId":"NCT02821156","phase":"","title":"Study on the Use of Inhaled NO (iNO)","status":"COMPLETED","sponsor":"Air Liquide Santé International","startDate":"2014-09","conditions":"Pulmonary Hypertension","enrollment":239},{"nctId":"NCT01388842","phase":"PHASE2","title":"Evaluation of the Efficacy and Safety of Inhaled Nitric Oxide as Adjunctive Treatment for Cerebral Malaria in Children","status":"COMPLETED","sponsor":"Epicentre","startDate":"2011-09","conditions":"Malaria, Cerebral","enrollment":92},{"nctId":"NCT01558466","phase":"PHASE3","title":"Sildenofil in Persistent Pulmonary Hypertension in Newborns","status":"UNKNOWN","sponsor":"Hamad Medical Corporation","startDate":"2011-11","conditions":"Persistent Fetal Circulation Syndrome","enrollment":100}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":69,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Inhaled Nitric Oxide (iNO) use","genericName":"Inhaled Nitric Oxide (iNO) use","companyName":"The University of Texas Health Science Center, Houston","companyId":"the-university-of-texas-health-science-center-houston","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Inhaled nitric oxide is a vasodilator gas that selectively relaxes pulmonary vascular smooth muscle to reduce pulmonary hypertension and improve oxygenation. Used for Persistent pulmonary hypertension of the newborn (PPHN), Acute respiratory distress syndrome (ARDS) with pulmonary hypertension, Pulmonary hypertension associated with left heart disease.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}