{"id":"inggenol-mebutate-0-015","safety":{"commonSideEffects":[{"rate":"80–90","effect":"Erythema"},{"rate":"70–80","effect":"Flaking/scaling"},{"rate":"60–70","effect":"Crusting"},{"rate":"40–50","effect":"Swelling/edema"},{"rate":"20–30","effect":"Erosion"},{"rate":"30–40","effect":"Pain/burning"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ingenol mebutate is a diterpene ester that directly activates protein kinase C isoforms in keratinocytes, leading to rapid cell death and disruption of the lesion. Additionally, it stimulates local innate immune responses, including neutrophil infiltration and cytokine production, which contribute to clearance of residual dysplastic cells in the treated area.","oneSentence":"Ingenol mebutate activates protein kinase C (PKC) to induce rapid necrosis of actinic keratosis cells and trigger immune-mediated clearance of remaining lesions.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:48:54.747Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Actinic keratosis (field treatment on face or scalp)"}]},"trialDetails":[{"nctId":"NCT02446223","phase":"PHASE4","title":"Evaluate the Efficacy and Safety of Large-Scale Field-Directed Topical Therapy of Actinic Keratosis of the Chest w/Ingenol Mebutate 0.015%","status":"COMPLETED","sponsor":"Goldman, Butterwick, Fitzpatrick and Groff","startDate":"2015-01","conditions":"Actinic Keratosis","enrollment":21}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":24,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Inggenol Mebutate 0.015%","genericName":"Inggenol Mebutate 0.015%","companyName":"Goldman, Butterwick, Fitzpatrick and Groff","companyId":"goldman-butterwick-fitzpatrick-and-groff","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ingenol mebutate activates protein kinase C (PKC) to induce rapid necrosis of actinic keratosis cells and trigger immune-mediated clearance of remaining lesions. Used for Actinic keratosis (field treatment on face or scalp).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}