{"id":"ingenol-metabute","safety":{"commonSideEffects":[{"rate":null,"effect":"Application site erythema"},{"rate":null,"effect":"Application site pain"},{"rate":null,"effect":"Application site pruritus"},{"rate":null,"effect":"Application site edema"}]},"_chembl":{"chemblId":"CHEMBL2165402","moleculeType":"Small molecule","molecularWeight":"348.44"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ingenol mebutate activates protein kinase C, leading to direct cytotoxic effects on keratinocytes and induction of local inflammatory responses. This dual mechanism—direct cell death combined with immune activation—results in clearance of actinic keratosis lesions. The drug is applied topically and works through both intrinsic apoptotic pathways and PKC-dependent signaling.","oneSentence":"Ingenol mebutate is a protein kinase C (PKC) activator that induces rapid necrosis of actinic keratosis cells and promotes immune-mediated clearance of treated lesions.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:16:08.623Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Actinic keratosis (field treatment on face or scalp)"}]},"trialDetails":[{"nctId":"NCT01541553","phase":"PHASE3","title":"A Sequential Treatment Regimen of Cryotherapy and Picato® for the Treatment of Actinic Keratosis on the Face and Scalp","status":"COMPLETED","sponsor":"LEO Pharma","startDate":"2012-03","conditions":"Actinic Keratosis","enrollment":367}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Picato® gel, 0.015%"],"phase":"phase_3","status":"active","brandName":"Ingenol metabute","genericName":"Ingenol metabute","companyName":"LEO Pharma","companyId":"leo-pharma","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ingenol mebutate is a protein kinase C (PKC) activator that induces rapid necrosis of actinic keratosis cells and promotes immune-mediated clearance of treated lesions. Used for Actinic keratosis (field treatment on face or scalp).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}