{"id":"influenza-vaccine-gsk2186877a","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site reactions (pain, erythema, swelling)"},{"rate":null,"effect":"Myalgia"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Fatigue"}]},"_chembl":{"chemblId":"CHEMBL2109042","moleculeType":"Vaccine component"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"As an influenza vaccine candidate, GSK2186877A likely works by presenting influenza antigens to the immune system to generate both humoral (antibody) and cellular (T-cell) immune responses. This primes the body to recognize and rapidly respond to natural influenza infection, reducing disease severity and transmission. The specific formulation or adjuvant strategy employed by GSK distinguishes this candidate from existing seasonal influenza vaccines.","oneSentence":"GSK2186877A is an investigational influenza vaccine designed to stimulate immune responses against influenza virus through antigen presentation and adaptive immunity.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:16:04.775Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Influenza prevention"}]},"trialDetails":[{"nctId":"NCT01096056","phase":"PHASE1","title":"Trial to Evaluate the Safety and the Immunogenicity of GSK Biologicals' Influenza Vaccine GSK2186877A in Healthy Children","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2010-04-05","conditions":"Influenza","enrollment":40},{"nctId":"NCT00992784","phase":"PHASE3","title":"Study to Evaluate the Safety and Immunogenicity of GlaxoSmithKline Biologicals' Influenza Vaccine in Elderly People","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2009-10-15","conditions":"Influenza","enrollment":370},{"nctId":"NCT00938392","phase":"PHASE3","title":"Study to Evaluate the Immunogenicity and Safety of an Investigational Influenza Vaccine for the Elderly","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2009-07-30","conditions":"Influenza","enrollment":726},{"nctId":"NCT00760617","phase":"PHASE3","title":"Evaluation of Safety and Immunogenicity of GSK Biologicals' Influenza Vaccine GSK2186877A in Adults 65 Years and Older","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2008-10-06","conditions":"Influenza","enrollment":526},{"nctId":"NCT00772889","phase":"PHASE3","title":"Evaluation of the Safety and Immunogenicity of the Influenza Vaccine GSK2186877A in the Elderly","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2008-10-09","conditions":"Influenza","enrollment":971},{"nctId":"NCT00765076","phase":"PHASE3","title":"Clinical Study of the Immunogenicity of GSK Biologicals' Influenza Vaccine GSK2186877A in People Aged 65 Years or Older","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2008-10-16","conditions":"Influenza","enrollment":192},{"nctId":"NCT00753272","phase":"PHASE3","title":"Trial to Evaluate the Efficacy of GSK Biologicals' Influenza Vaccine GSK2186877A in Adults 65 Year of Age and Older","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2008-09-15","conditions":"Influenza","enrollment":43695}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Influenza vaccine GSK2186877A","genericName":"Influenza vaccine GSK2186877A","companyName":"GlaxoSmithKline","companyId":"gsk","modality":"Biologic","firstApprovalDate":"","aiSummary":"GSK2186877A is an investigational influenza vaccine designed to stimulate immune responses against influenza virus through antigen presentation and adaptive immunity. Used for Influenza prevention.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}