{"id":"infliximab-ifx-alone","safety":{"commonSideEffects":[{"rate":"5-10","effect":"Infections (including serious infections)"},{"rate":"3-5","effect":"Infusion reactions"},{"rate":"5-10","effect":"Headache"},{"rate":"3-8","effect":"Abdominal pain"},{"rate":"3-7","effect":"Nausea"},{"rate":"0.5-2","effect":"Tuberculosis reactivation"},{"rate":"low but increased","effect":"Malignancy risk (long-term)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Infliximab blocks TNF-α signaling by binding directly to soluble and membrane-bound TNF-α, preventing its interaction with TNF receptors on immune cells. This reduces the inflammatory cascade and immune activation in conditions driven by excessive TNF-α production. It is used to treat autoimmune and inflammatory diseases where TNF-α plays a central pathogenic role.","oneSentence":"Infliximab is a monoclonal antibody that binds to and neutralizes tumor necrosis factor-alpha (TNF-α), a key inflammatory cytokine.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:48:27.011Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Rheumatoid arthritis"},{"name":"Crohn's disease"},{"name":"Ulcerative colitis"},{"name":"Ankylosing spondylitis"},{"name":"Psoriasis"},{"name":"Psoriatic arthritis"}]},"trialDetails":[{"nctId":"NCT03765450","phase":"","title":"Pharmacokinetics of IFX and TNF Concentrations in Serum, Stool, and Colonic Mucosa in Acute Severe Ulcerative Colitis","status":"ACTIVE_NOT_RECRUITING","sponsor":"Alimentiv Inc.","startDate":"2018-12-21","conditions":"Ulcerative Colitis","enrollment":18},{"nctId":"NCT06059989","phase":"PHASE3","title":"InDuctIon TREatment with SubCuTaneous Infliximab for Crohn's Disease","status":"RECRUITING","sponsor":"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)","startDate":"2021-11-25","conditions":"Inflammatory Disease, Disease Crohn, Bowel Disease","enrollment":158},{"nctId":"NCT02425852","phase":"PHASE4","title":"A Randomized, Multicenter Open Label Study Comparing Early Administration of Azathioprine Plus IFX to Steroids Plus Azathioprine for Acute Severe Colitis","status":"COMPLETED","sponsor":"Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives","startDate":"2016-12","conditions":"Ulcerative Colitis","enrollment":65},{"nctId":"NCT04165265","phase":"NA","title":"The Use of Web-app Constant-Care in Patients With Acute Severe Ulcerative Colitis Treated With Rescue Therapy","status":"UNKNOWN","sponsor":"Nordsjaellands Hospital","startDate":"2019-12-03","conditions":"Ulcerative Colitis, Telemedicine","enrollment":28},{"nctId":"NCT00537316","phase":"PHASE3","title":"Efficacy & Safety of Infliximab Monotherapy Vs Combination Therapy Vs AZA Monotherapy in Ulcerative Colitis (Part 1) Maintenance Vs Intermittent Therapy for Maintaining Remission (Part 2)(Study P04807)","status":"TERMINATED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2007-07","conditions":"Ulcerative Colitis","enrollment":242},{"nctId":"NCT00367237","phase":"PHASE3","title":"Remicade Study in Psoriatic Arthritis Patients Of Methotrexate-Naïve Disease (RESPOND) (Study P04422)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2006-05","conditions":"Arthritis, Psoriatic","enrollment":115},{"nctId":"NCT02771457","phase":"PHASE3","title":"Managing Infliximab Reinduction After Temporary Discontinuation of Drug","status":"WITHDRAWN","sponsor":"NYU Langone Health","startDate":"2016-07","conditions":"Inflammatory Bowel Disease","enrollment":""},{"nctId":"NCT01015547","phase":"PHASE3","title":"Aggressive Combination Drug Therapy in Very Early Polyarticular Juvenile Idiopathic Arthritis","status":"COMPLETED","sponsor":"Helsinki University Central Hospital","startDate":"2003-05","conditions":"Juvenile Idiopathic Arthritis","enrollment":60},{"nctId":"NCT02088944","phase":"","title":"a Single-center Registered Clinical Research of Chinese Patients With Moderate to Severe Crohn's Disease","status":"UNKNOWN","sponsor":"Nanfang Hospital, Southern Medical University","startDate":"2014-03","conditions":"Serological C Reactive Protein or Erythrocyte Sedimentation Rate","enrollment":142},{"nctId":"NCT01559142","phase":"PHASE3","title":"Efficacy and Safety of Two Regimens of Maintenance Therapy in Children With Crohn Disease","status":"UNKNOWN","sponsor":"Children's Memorial Health Institute, Poland","startDate":"2008-11","conditions":"Crohn Disease","enrollment":100},{"nctId":"NCT00396747","phase":"PHASE4","title":"A Comparison of Methotrexate Alone or Combined to Infliximab or to Pulse Methylprednisolone in Early Rheumatoid Arthritis: A Magnetic Resonance Imaging Study","status":"COMPLETED","sponsor":"Université Catholique de Louvain","startDate":"2003-06","conditions":"Rheumatoid Arthritis","enrollment":45}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":75,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Infliximab (IFX alone)","genericName":"Infliximab (IFX alone)","companyName":"Children's Memorial Health Institute, Poland","companyId":"children-s-memorial-health-institute-poland","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Infliximab is used to treat conditions such as Ulcerative Colitis, Arthritis, Psoriatic Arthritis, Juvenile Idiopathic Arthritis, and Rheumatoid Arthritis, as well as Crohn's Disease. The exact mechanism of action of Infliximab is not specified in the provided facts, but it is known to be used in combination with other interventions such as Azathioprine and Prednisolone.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}