{"id":"indomethacin-capsules-high-dose","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Gastrointestinal upset"},{"rate":"5-10%","effect":"Renal impairment"},{"rate":"1-5%","effect":"Hypersensitivity reactions"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Indomethacin acts by inhibiting the enzyme cyclooxygenase (COX), which is responsible for the production of prostaglandins. This results in a decrease in the production of prostaglandins, which are mediators of inflammation and pain.","oneSentence":"Non-selective COX-1 and COX-2 inhibitor","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T03:36:16.653Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Osteoarthritis"},{"name":"Rheumatoid arthritis"}]},"trialDetails":[{"nctId":"NCT01265849","phase":"PHASE3","title":"Efficacy and Safety Study of Leukocyte Interleukin,Injection (LI) to Treat Cancer of the Oral Cavity","status":"COMPLETED","sponsor":"CEL-SCI Corporation","startDate":"2010-12","conditions":"Squamous Cell Carcinoma of the Oral Cavity, Squamous Cell Carcinoma of the Soft Palate","enrollment":928},{"nctId":"NCT01789216","phase":"PHASE3","title":"Improving Pain Management and Long Term Outcomes Following High Energy Orthopedic Trauma (Pain Study)","status":"COMPLETED","sponsor":"Major Extremity Trauma Research Consortium","startDate":"2013-07","conditions":"Orthopaedic Fractures","enrollment":450},{"nctId":"NCT02633969","phase":"PHASE2","title":"Study of Indomethacin Capsules to Treat Pain Following Surgery in Children Ages 6 to <17 Years of Age","status":"COMPLETED","sponsor":"Iroko Pharmaceuticals, LLC","startDate":"2015-12","conditions":"Pain, Postoperative","enrollment":30},{"nctId":"NCT02183155","phase":"PHASE4","title":"Effect of Meloxicam Tablets on Bleeding Time in Healthy Subjects","status":"COMPLETED","sponsor":"Boehringer Ingelheim","startDate":"2000-05","conditions":"Healthy","enrollment":82}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_2","status":"active","brandName":"Indomethacin Capsules high dose","genericName":"Indomethacin Capsules high dose","companyName":"Iroko Pharmaceuticals, LLC","companyId":"iroko-pharmaceuticals-llc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Non-selective COX-1 and COX-2 inhibitor Used for Osteoarthritis, Rheumatoid arthritis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}