{"id":"indometacin-cataplasms","safety":{"commonSideEffects":[{"rate":null,"effect":"Local skin irritation or rash"},{"rate":null,"effect":"Contact dermatitis"},{"rate":null,"effect":"Mild burning or stinging at application site"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Indomethacin blocks COX-1 and COX-2 enzymes, which are responsible for producing prostaglandins that mediate inflammation, pain, and fever. When formulated as a cataplasm (medicated paste or poultice applied to skin), it delivers the drug locally to affected tissues, reducing inflammatory mediators at the site of application. This topical delivery minimizes systemic exposure compared to oral formulations.","oneSentence":"Indomethacin, a nonsteroidal anti-inflammatory drug (NSAID), inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation and pain when applied topically as a cataplasm (poultice).","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:40:44.968Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Topical treatment of localized inflammation and pain (e.g., joint pain, muscle pain, arthritis)"},{"name":"Traditional Chinese medicine application for inflammatory conditions"}]},"trialDetails":[{"nctId":"NCT02770950","phase":"PHASE4","title":"Zushima Plaster for Treating Knee Osteoarthritis","status":"COMPLETED","sponsor":"Guang'anmen Hospital of China Academy of Chinese Medical Sciences","startDate":"2016-05","conditions":"Osteoarthritis","enrollment":396}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Indometacin Cataplasms","genericName":"Indometacin Cataplasms","companyName":"Guang'anmen Hospital of China Academy of Chinese Medical Sciences","companyId":"guang-anmen-hospital-of-china-academy-of-chinese-medical-sciences","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Indomethacin, a nonsteroidal anti-inflammatory drug (NSAID), inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation and pain when applied topically as a cataplasm (poultice). Used for Topical treatment of localized inflammation and pain (e.g., joint pain, muscle pain, arthritis), Traditional Chinese medicine application for inflammatory conditions.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}