{"id":"individualized-oral-morphine","safety":{"commonSideEffects":[{"rate":null,"effect":"Constipation"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Drowsiness"},{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Dizziness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Morphine is an opioid agonist that binds to mu, delta, and kappa opioid receptors throughout the nervous system. This binding modulates pain signal transmission and alters the emotional response to pain. The individualized formulation allows for dose customization based on patient-specific factors, particularly important in pediatric populations where dosing must be carefully titrated.","oneSentence":"Morphine binds to opioid receptors in the central and peripheral nervous system to reduce pain perception and provide analgesia.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:48:43.755Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Moderate to severe pain in pediatric patients"},{"name":"Cancer pain in children"}]},"trialDetails":[{"nctId":"NCT06837857","phase":"PHASE2","title":"Prescription Opioids, Brain Structure, and Cognition in Older Adults With Chronic Pain","status":"RECRUITING","sponsor":"Mayo Clinic","startDate":"2025-04-16","conditions":"Pain, Chronic","enrollment":200},{"nctId":"NCT04527393","phase":"PHASE4","title":"Individualized Analgesia for Pediatric Adenotonsillectomy","status":"COMPLETED","sponsor":"Children's Hospital of Fudan University","startDate":"2022-05-01","conditions":"Adenotonsillectomy, Analgesia","enrollment":542},{"nctId":"NCT04132011","phase":"PHASE4","title":"Dosing Intervals of Opioid Medication for Chronic Pain","status":"WITHDRAWN","sponsor":"University Health Network, Toronto","startDate":"2019-05-01","conditions":"Chronic Pain","enrollment":""},{"nctId":"NCT03824834","phase":"PHASE2","title":"Morphine to Maximize the Benefits of Exercise Training in COPD or ILD and Persistent Breathlessness","status":"UNKNOWN","sponsor":"Dennis Jensen, Ph.D.","startDate":"2019-08-06","conditions":"Chronic Obstructive Pulmonary Disease, Interstitial Lung Disease","enrollment":40},{"nctId":"NCT03518463","phase":"NA","title":"Enhanced Recovery After Surgery for Emergency Caesarean Deliveries","status":"COMPLETED","sponsor":"Mbarara University of Science and Technology","startDate":"2017-06-20","conditions":"Pregnancy Related","enrollment":160}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1545,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Individualized group"],"phase":"marketed","status":"active","brandName":"Individualized oral morphine","genericName":"Individualized oral morphine","companyName":"Children's Hospital of Fudan University","companyId":"children-s-hospital-of-fudan-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Morphine binds to opioid receptors in the central and peripheral nervous system to reduce pain perception and provide analgesia. Used for Moderate to severe pain in pediatric patients, Cancer pain in children.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}