{"id":"indapamide-t2","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypokalemia"},{"rate":null,"effect":"Hyperglycemia"},{"rate":null,"effect":"Hyperuricemia"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Fatigue"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Indapamide works primarily by blocking the sodium-chloride cotransporter in the distal convoluted tubule, leading to increased urinary sodium and water excretion. This reduces intravascular volume and peripheral vascular resistance, thereby lowering blood pressure. It also has mild vasodilatory properties independent of its diuretic effect.","oneSentence":"Indapamide is a thiazide-like diuretic that inhibits sodium reabsorption in the distal convoluted tubule of the kidney, reducing blood volume and lowering blood pressure.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:33:18.800Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertension"},{"name":"Edema associated with congestive heart failure"}]},"trialDetails":[{"nctId":"NCT00128518","phase":"PHASE4","title":"IDEAL Study: Identification of the Determinants of the Efficacy of Arterial Blood Pressure Lowering Drugs","status":"COMPLETED","sponsor":"Hospices Civils de Lyon","startDate":"2004-10","conditions":"Hypertension","enrollment":139}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Indapamide (T2)","genericName":"Indapamide (T2)","companyName":"Hospices Civils de Lyon","companyId":"hospices-civils-de-lyon","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Indapamide is a thiazide-like diuretic that inhibits sodium reabsorption in the distal convoluted tubule of the kidney, reducing blood volume and lowering blood pressure. Used for Hypertension, Edema associated with congestive heart failure.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}