{"id":"incretin-analogues","safety":{"commonSideEffects":[{"rate":"20-40","effect":"Nausea"},{"rate":"5-15","effect":"Vomiting"},{"rate":"10-20","effect":"Diarrhea"},{"rate":"10-20","effect":"Constipation"},{"rate":"5-10","effect":"Headache"},{"rate":"5-10","effect":"Hypoglycemia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Incretin analogues are synthetic versions of glucagon-like peptide-1 (GLP-1) or glucose-dependent insulinotropic polypeptide (GIP) that enhance the body's natural incretin effect. These agents bind to incretin receptors on pancreatic beta cells, triggering glucose-dependent insulin secretion while simultaneously suppressing glucagon release. This mechanism is particularly effective postprandially and carries a lower hypoglycemia risk compared to insulin secretagogues.","oneSentence":"Incretin analogues mimic the action of incretin hormones to stimulate insulin secretion in response to glucose intake, thereby lowering blood glucose levels in patients with type 2 diabetes.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:33:23.898Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Type 2 diabetes mellitus"}]},"trialDetails":[{"nctId":"NCT02029846","phase":"PHASE4","title":"Glycemia in Diabetic Elders Trial","status":"TERMINATED","sponsor":"Johns Hopkins University","startDate":"2013-04","conditions":"Type 2 Diabetes Mellitus","enrollment":2},{"nctId":"NCT02041234","phase":"PHASE4","title":"Roux-en-Y Gastric Bypass for BMI 27-32 Type 2 Diabetes Versus Best Medical Treatment","status":"COMPLETED","sponsor":"Khoo Teck Puat Hospital","startDate":"2014-02","conditions":"Type II Diabetes in Subjects BMI 27 to 32","enrollment":40},{"nctId":"NCT03103009","phase":"PHASE1","title":"Treatment Plan for an Individual Patient With Pasireotide for Hyperinsulinemic Hypoglycemia","status":"COMPLETED","sponsor":"University of Colorado, Denver","startDate":"2017-03-22","conditions":"Hyperinsulinemic Hypoglycemia, Post Gastrointestinal Tract Surgery Hypoglycaemia","enrollment":1},{"nctId":"NCT02036138","phase":"PHASE2, PHASE3","title":"The Efficacy of Bariatric Surgery Compared to Medical Therapy in Controlling Type2 Diabetes Mellitus in Patients With Non Morbid Obesity.","status":"UNKNOWN","sponsor":"Hadassah Medical Organization","startDate":"2015-01","conditions":"Overweight, Diabetes Type 2","enrollment":76},{"nctId":"NCT01934816","phase":"NA","title":"Incretin and KATP Channels","status":"TERMINATED","sponsor":"Katarina Kos","startDate":"2013-06","conditions":"Healthy Subjects","enrollment":2},{"nctId":"NCT02476760","phase":"","title":"Incretin-based Drugs and Acute Pancreatitis","status":"COMPLETED","sponsor":"Canadian Network for Observational Drug Effect Studies, CNODES","startDate":"2014-03","conditions":"Diabetes Mellitus, Type 2","enrollment":1417914},{"nctId":"NCT02456428","phase":"","title":"Incretin-based Drugs and the Risk of Heart Failure","status":"COMPLETED","sponsor":"Canadian Network for Observational Drug Effect Studies, CNODES","startDate":"2014-03","conditions":"Type 2 Diabetes Mellitus","enrollment":1499650}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":40,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Liraglutide"],"phase":"marketed","status":"active","brandName":"Incretin analogues","genericName":"Incretin analogues","companyName":"Khoo Teck Puat Hospital","companyId":"khoo-teck-puat-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Incretin analogues are small molecule drugs used to treat conditions such as type 2 diabetes and overweight, often in combination with other treatments like insulin or DPP-4 inhibitors. They are studied in clinical trials for their potential effects on type 2 diabetes and other related conditions, including acute pancreatitis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}