{"id":"incobotulinumtoxin-a-injectable-product","safety":{"commonSideEffects":[{"rate":"5-15","effect":"Headache"},{"rate":"5-10","effect":"Injection site pain or bruising"},{"rate":"1-5","effect":"Muscle weakness"},{"rate":"1-3","effect":"Eyelid ptosis"},{"rate":"1-3","effect":"Dry mouth"},{"rate":"2-5","effect":"Neck pain"}]},"_chembl":{"chemblId":"CHEMBL2094006","moleculeType":"Small molecule","molecularWeight":"702.93"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This botulinum toxin serotype A derivative irreversibly cleaves SNAP-25, a protein essential for acetylcholine vesicle fusion and release at the neuromuscular junction. This results in temporary flaccid paralysis of injected muscles. The effect is reversible over months as new neuromuscular junctions form.","oneSentence":"Incobotulinumtoxin A blocks acetylcholine release at the neuromuscular junction by cleaving SNARE proteins, causing temporary muscle paralysis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:48:33.142Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cervical dystonia"},{"name":"Blepharospasm"},{"name":"Hemifacial spasm"},{"name":"Glabellar lines (aesthetic)"},{"name":"Crow's feet (aesthetic)"},{"name":"Forehead lines (aesthetic)"}]},"trialDetails":[{"nctId":"NCT04075981","phase":"PHASE3","title":"Prevention Atrial Fibrillation by BOTulinum Toxin Injections (BOTAF)","status":"RECRUITING","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2019-09-30","conditions":"Cardiac Surgery","enrollment":220},{"nctId":"NCT04922983","phase":"PHASE2","title":"Incobotulinumtoxin A and Yoga-like Isometric Exercise in Adolescent Idiopathic Lumbar Scoliosis","status":"UNKNOWN","sponsor":"Manhattan Physical Medicine and Rehabilitation, LLP","startDate":"2021-07-01","conditions":"Scoliosis Idiopathic, Scoliosis; Adolescence, Scoliosis; Lumbar Region","enrollment":42},{"nctId":"NCT02444169","phase":"","title":"Retrospective Evaluation of Combination Treatment With the Ulthera System","status":"COMPLETED","sponsor":"Ulthera, Inc","startDate":"2015-04","conditions":"Skin Laxity","enrollment":101},{"nctId":"NCT03048383","phase":"PHASE4","title":"Comparison of Three Botulinum Neuromodulators for Management of Facial Synkinesis","status":"COMPLETED","sponsor":"University of Utah","startDate":"2012-07","conditions":"Facial Nerve Injuries, Facial Paresis Associated With Facial Nerve Dysfunction, Facial Asymmetry","enrollment":71},{"nctId":"NCT01931878","phase":"PHASE2","title":"Investigation of Efficacy of incobotulinumtoxinA (Xeomin) in Relieving Symptoms of Restless Leg Syndrome.","status":"COMPLETED","sponsor":"Yale University","startDate":"2012-09","conditions":"Restless Leg Syndrome","enrollment":24}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Xeomin"],"phase":"marketed","status":"active","brandName":"Incobotulinumtoxin A Injectable Product","genericName":"Incobotulinumtoxin A Injectable Product","companyName":"University of Utah","companyId":"university-of-utah","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Incobotulinumtoxin A blocks acetylcholine release at the neuromuscular junction by cleaving SNARE proteins, causing temporary muscle paralysis. Used for Cervical dystonia, Blepharospasm, Hemifacial spasm.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}