{"id":"in-ketamine","safety":{"commonSideEffects":[{"rate":null,"effect":"Dissociation"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Sedation"}]},"_chembl":{"chemblId":"CHEMBL742","moleculeType":"Small molecule","molecularWeight":"237.73"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ketamine antagonizes N-methyl-D-aspartate (NMDA) receptors, which are ionotropic glutamate receptors involved in excitatory neurotransmission. This blockade leads to rapid disinhibition of downstream neural circuits and activation of mammalian target of rapamycin (mTOR) signaling, promoting synaptic plasticity and neurogenesis. The intranasal formulation enables rapid CNS penetration and faster onset of therapeutic effects compared to systemic administration.","oneSentence":"Intranasal ketamine is a rapid-acting NMDA receptor antagonist that blocks glutamate signaling in the brain to produce fast-onset antidepressant and analgesic effects.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:15:45.289Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Treatment-resistant depression"},{"name":"Acute suicidal ideation and behavior"},{"name":"Chronic pain conditions"}]},"trialDetails":[{"nctId":"NCT07435077","phase":"PHASE4","title":"Examining Analgesic Synergy and Efficacy in Trauma Care","status":"NOT_YET_RECRUITING","sponsor":"Wake Forest University Health Sciences","startDate":"2026-05","conditions":"Opioid Use Disorder","enrollment":282},{"nctId":"NCT06464146","phase":"PHASE3","title":"Pain Reduction for Limb Injuries in Pediatric Emergency Departments: Intranasal Fentanyl or Intranasal Ketamine vs Oral Morphine","status":"RECRUITING","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2025-02-26","conditions":"Limb Injury","enrollment":300},{"nctId":"NCT07066306","phase":"NA","title":"Effects of Local Ketamine in Orthognathic Procedures","status":"ACTIVE_NOT_RECRUITING","sponsor":"Bezmialem Vakif University","startDate":"2025-06-21","conditions":"Dentofacial Deformities, Analgesia, Vomiting, Postoperative","enrollment":40},{"nctId":"NCT04751175","phase":"PHASE4","title":"Management of Pain in Lumbar Arthrodesis","status":"COMPLETED","sponsor":"Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta","startDate":"2013-07-04","conditions":"Pain, Postoperative","enrollment":128},{"nctId":"NCT05277896","phase":"PHASE4","title":"Randomized Trial of Sedative Choice for Intubation","status":"COMPLETED","sponsor":"Vanderbilt University Medical Center","startDate":"2022-04-06","conditions":"Acute Respiratory Failure","enrollment":2367},{"nctId":"NCT03336398","phase":"PHASE2","title":"Investigation of the NMDA Antagonist Ketamine as a Treatment for Tinnitus","status":"COMPLETED","sponsor":"New York State Psychiatric Institute","startDate":"2019-09-01","conditions":"Tinnitus","enrollment":42},{"nctId":"NCT07482709","phase":"PHASE1, PHASE2","title":"Comparison Between Tranversus Abdominis Plane (TAP) Block With Only Bupivacaine and TAP Block With Bupivacaine Plus Ketamine in Reducing Postoperative Pain After Total Abdominal Hystrectomy","status":"RECRUITING","sponsor":"Liaquat National Hospital & Medical College","startDate":"2025-11-01","conditions":"Post Operative Pain in Total Abdominal Hystrectomy","enrollment":30},{"nctId":"NCT06378528","phase":"EARLY_PHASE1","title":"Ketamine-assisted Psychotherapy for Adolescent PTSD (KAP)","status":"SUSPENDED","sponsor":"University of Wisconsin, Madison","startDate":"2026-09","conditions":"Posttraumatic Stress Disorder","enrollment":5},{"nctId":"NCT06903819","phase":"PHASE4","title":"Ketamine for Pain, Opioid Use, and Mental Health in Orthopedic Trauma Patients","status":"RECRUITING","sponsor":"Texas Tech University Health Sciences Center","startDate":"2025-11-06","conditions":"Orthopedic Trauma Surgery Patients, Postoperative Pain, Opioid Use","enrollment":90},{"nctId":"NCT07410702","phase":"","title":"Correlating EEG Dynamics With Consciousness Alteration Under Anesthesia","status":"RECRUITING","sponsor":"Huazhong University of Science and Technology","startDate":"2026-02-10","conditions":"Altered State of Consciousness, General Anesthetics","enrollment":250},{"nctId":"NCT07490457","phase":"NA","title":"Intraoperative Ketamine for Chronic Postoperative Pain After Open-Heart Surgery","status":"NOT_YET_RECRUITING","sponsor":"Bursa City Hospital","startDate":"2026-04-15","conditions":"Cardiac Anaesthesia, Chronic Pain, Post Operative Pain, Chronic","enrollment":100},{"nctId":"NCT04578938","phase":"PHASE4","title":"Ketamine + Cognitive Training for Suicidality in the Medical Setting","status":"ACTIVE_NOT_RECRUITING","sponsor":"Rebecca Price","startDate":"2021-03-15","conditions":"Suicide, Attempted","enrollment":200},{"nctId":"NCT07139106","phase":"PHASE4","title":"Understanding the Role of the Kappa Opioid Receptor in Ketamine's Attenuation of Suicidal Thoughts","status":"NOT_YET_RECRUITING","sponsor":"New York State Psychiatric Institute","startDate":"2026-05-01","conditions":"Major Depressive Disorder (MDD)","enrollment":12},{"nctId":"NCT07001605","phase":"NA","title":"Erector Spinae Block Vs Ketamine-based Multimodal Analgesia Protocol in Lumber Decompressive Surgery","status":"COMPLETED","sponsor":"Kasr El Aini Hospital","startDate":"2025-06-20","conditions":"Spinal Decompression, Analgesia, Erector Spinae Plane Block","enrollment":62},{"nctId":"NCT06480201","phase":"PHASE1","title":"Gamma Oscillations as a Prognostic Marker for Ketamine Therapy in Treatment Resistant Depression","status":"SUSPENDED","sponsor":"Texas A&M University","startDate":"2024-01-01","conditions":"Healthy, Major Depressive Disorder, Treatment Resistant Depression","enrollment":100},{"nctId":"NCT07489001","phase":"","title":"Opioid Free and Opioid Based Anesthesia in Elective Lumbar Spine Surgery","status":"RECRUITING","sponsor":"Marmara University","startDate":"2025-12-09","conditions":"Lumbar Spinal Stenosis, Lumbar Disc Herniation With Radiculopathy, Lumbar Degenerative Spondylolisthesis","enrollment":75},{"nctId":"NCT07486336","phase":"NA","title":"Awareness Neuraxial Versus General Anesthesia in Frail Patients Undergoing Laparoscopic or Robotic Abdominopelvic Surgery.","status":"NOT_YET_RECRUITING","sponsor":"Ente Ospedaliero Ospedali Galliera","startDate":"2026-09-01","conditions":"Fraily, Abdominal Surgery, Postoperative Cognitive Dysfunction (POCD)","enrollment":100},{"nctId":"NCT06231563","phase":"PHASE2","title":"Ketamine for Veterans With Parkinson's Disease","status":"RECRUITING","sponsor":"VA Office of Research and Development","startDate":"2026-03-01","conditions":"Parkinson's Disease","enrollment":80},{"nctId":"NCT04763343","phase":"PHASE3","title":"Ketamine Treatment of Youth Suicide Attempters","status":"RECRUITING","sponsor":"Tatiana Falcone, MD","startDate":"2022-06-27","conditions":"Suicide, Attempted","enrollment":60},{"nctId":"NCT05378100","phase":"PHASE2","title":"Ketamine for Multiple Sclerosis Fatigue","status":"ACTIVE_NOT_RECRUITING","sponsor":"Johns Hopkins University","startDate":"2023-01-01","conditions":"Multiple Sclerosis Fatigue","enrollment":110},{"nctId":"NCT05446623","phase":"PHASE2, PHASE3","title":"Cardiac Index and General Anesthesia Without Opioid.","status":"COMPLETED","sponsor":"Centre Hospitalier de Montauban","startDate":"2021-01-01","conditions":"Hip Arthropathy, Hip Disease","enrollment":120},{"nctId":"NCT06340958","phase":"PHASE2","title":"A Study of CLE-100 (Oral Esketamine) as an Adjunctive Treatment to Standard Antidepressants for Major Depressive Disorder","status":"COMPLETED","sponsor":"Clexio Biosciences Ltd.","startDate":"2024-03-18","conditions":"Adjunctive Treatment of Major Depressive Disorder (MDD)","enrollment":99},{"nctId":"NCT07396272","phase":"PHASE2","title":"A Clinical Trial of Add-on Oral Slow-release Ketamine Treatment in Major Depression","status":"RECRUITING","sponsor":"Daniel Lindqvist","startDate":"2026-04-01","conditions":"Major Depressive Disorder (MDD)","enrollment":12},{"nctId":"NCT07479602","phase":"PHASE4","title":"Intranasal Dexmedetomidine-esketamine Administration and Postoperative Pain in Pediatric Patients","status":"NOT_YET_RECRUITING","sponsor":"Peking University First Hospital","startDate":"2026-04","conditions":"Adenotonsillectomy, Children, Intranasal Administration","enrollment":160},{"nctId":"NCT07276542","phase":"PHASE2, PHASE3","title":"Clinical Trial Exploring the Outpatient Treatment of Phantom Limb Pain With Ketamine Administration in a Six Month Study With a Minimum Remission Period of 7 Days Between Treatment Session. 25-30 Subjects With an Ongoing History of Significant PLP.--FDA and IRB Approved.","status":"RECRUITING","sponsor":"The Ketamine Research Foundation","startDate":"2026-01-15","conditions":"Phantom Limb Syndrome With Pain","enrollment":30},{"nctId":"NCT07476482","phase":"NA","title":"The Impact of a Shared Decision-Making Intervention on Intraoperative Patient Experience During Elective Cesarean Delivery Under Spinal Anesthesia","status":"ENROLLING_BY_INVITATION","sponsor":"Alexandria University","startDate":"2026-04-01","conditions":"Decision Making , Cesarean Section","enrollment":80},{"nctId":"NCT07315074","phase":"NA","title":"Effect of Esketamine on Postoperative Sleep in Postmenopausal Women","status":"NOT_YET_RECRUITING","sponsor":"Zhuan Zhang","startDate":"2026-03-01","conditions":"Circadian Rhythm, Postoperative Sleep Disturbance","enrollment":164},{"nctId":"NCT05487885","phase":"PHASE4","title":"Anhedonia, Development, and Emotions: Phenotyping and Therapeutics","status":"COMPLETED","sponsor":"Erika Forbes","startDate":"2022-07-22","conditions":"Depression, Anhedonia","enrollment":123},{"nctId":"NCT07248202","phase":"NA","title":"Ketamine-lidocaine Versus Ketamine-fentanyl for Induction of Anesthesia in Patients With Left Ventricular Systolic Dysfunction Undergoing Elective Coronary Artery Bypass","status":"RECRUITING","sponsor":"Cairo University","startDate":"2025-12-01","conditions":"Coronary Artery Disease (CAD), Left Ventricular (LV) Systolic Dysfunction, Induction Anesthesia","enrollment":40},{"nctId":"NCT06781697","phase":"PHASE3","title":"InTRavenous kEtAmine and immerSive virtUal Reality to Treat dEpression","status":"NOT_YET_RECRUITING","sponsor":"Sunnybrook Health Sciences Centre","startDate":"2026-05","conditions":"Treatment Resistant Depression","enrollment":31},{"nctId":"NCT07227454","phase":"PHASE3","title":"A Study to Evaluate the Efficacy and Safety of Esketamine for Reduction of Symptoms of Major Depressive Disorder","status":"RECRUITING","sponsor":"Janssen Research & Development, LLC","startDate":"2026-01-08","conditions":"Depressive Disorder, Major","enrollment":258},{"nctId":"NCT07463911","phase":"","title":"Treatment Response In ECT Patients","status":"ACTIVE_NOT_RECRUITING","sponsor":"Nurdan Sağbaş","startDate":"2025-05-20","conditions":"Major Depression, Bipolar Affective Disorder, Bipolar Depression Depressed Phase","enrollment":65},{"nctId":"NCT07053345","phase":"PHASE4","title":"A Study of Esketamine Nasal Spray in Korean Participants With Treatment-resistant Depression","status":"RECRUITING","sponsor":"Janssen Korea, Ltd., Korea","startDate":"2025-06-09","conditions":"Depressive Disorder, Treatment-Resistant","enrollment":47},{"nctId":"NCT06608277","phase":"PHASE2","title":"Ketamine, SGB and Combination Treatment for TBI","status":"RECRUITING","sponsor":"Northwestern University","startDate":"2025-07-02","conditions":"Posttraumatic Headache, Posttraumatic Stress Disorder","enrollment":175},{"nctId":"NCT07284667","phase":"PHASE2","title":"ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response","status":"RECRUITING","sponsor":"ACADIA Pharmaceuticals Inc.","startDate":"2025-11-14","conditions":"Major Depressive Disorder (MDD), Depressive Disorder, Treatment-Resistant","enrollment":153},{"nctId":"NCT06402955","phase":"PHASE2","title":"Imaging Depression in Parkinson's Disease","status":"RECRUITING","sponsor":"Yale University","startDate":"2024-09-01","conditions":"Parkinson's Disease, Major Depressive Disorder","enrollment":120},{"nctId":"NCT07461376","phase":"NA","title":"Premedication in Children: a Clinical Trial Comparing Oral Ketamine and Oral Clonidine With Respect to Sedation Level and Opioid Consumption in Pediatrics Undergoing Elective Lower Abdominal Day-case Surgery.","status":"RECRUITING","sponsor":"Cairo University","startDate":"2025-04-15","conditions":"Pediatric Sedation, Clonidine Sedation, Ketamine Sedation","enrollment":84},{"nctId":"NCT07443254","phase":"PHASE1, PHASE2","title":"Prospective IR-led Sedation Feasibility","status":"RECRUITING","sponsor":"CAMC Health System","startDate":"2026-03-02","conditions":"Anesthesia, Sedation and Analgesia, Interventional Radiology","enrollment":40},{"nctId":"NCT05437575","phase":"PHASE3","title":"Prehospital Analgesia INtervention Trial (PAIN)","status":"RECRUITING","sponsor":"Jason Sperry","startDate":"2023-11-27","conditions":"Traumatic Injury","enrollment":994},{"nctId":"NCT07369024","phase":"PHASE2","title":"Sub-dissociative Dose Ketamine in Treatment of Vaso-occlusive Pain Event in Children and Young Adults","status":"RECRUITING","sponsor":"Mohsen Saidinejad","startDate":"2026-04-01","conditions":"Sickle Cell Disease, Vaso-Occlusive Pain Episode in Sickle Cell Disease, Ketamine Infusion","enrollment":120},{"nctId":"NCT07455565","phase":"NA","title":"Postoperative Pain Monitoring With ANI in Lumbar Spine Surgery","status":"RECRUITING","sponsor":"Akdeniz University Hospital","startDate":"2025-12-16","conditions":"Postoperative Pain, Lumbar Spine Surgery","enrollment":100},{"nctId":"NCT07452705","phase":"NA","title":"Small Study Comparing Two Pain Medicines in Teenagers for Pain Control After Scoliosis Corrective Surgery.","status":"NOT_YET_RECRUITING","sponsor":"University of Malaya","startDate":"2026-02-02","conditions":"Adolescent Idiopathic Scoliosis (AIS)","enrollment":114},{"nctId":"NCT06620276","phase":"NA","title":"ACT_for Alcohol Use Disorder and Depression","status":"RECRUITING","sponsor":"Centre hospitalier de l'Université de Montréal (CHUM)","startDate":"2025-05-01","conditions":"Depression - Major Depressive Disorder, Alcohol Use Disorder","enrollment":30},{"nctId":"NCT06575075","phase":"PHASE1, PHASE2","title":"Pilot Study of RR-HNK in OCD","status":"RECRUITING","sponsor":"Carolyn Rodriguez","startDate":"2026-01-23","conditions":"Obsessive-Compulsive Disorder","enrollment":45},{"nctId":"NCT07410078","phase":"NA","title":"Comparative Assessment of Oral Premedication Regimens in Pediatric Ambulatory Surgery","status":"NOT_YET_RECRUITING","sponsor":"Diskapi Yildirim Beyazit Education and Research Hospital","startDate":"2026-02-19","conditions":"Pediatric Anesthesia, Premedication","enrollment":135},{"nctId":"NCT04480918","phase":"","title":"University of Iowa Interventional Psychiatry Service Patient Registry","status":"RECRUITING","sponsor":"Mark Niciu","startDate":"2020-11-02","conditions":"Treatment Resistant Depression, Major Depressive Episode, Major Depression","enrollment":1000},{"nctId":"NCT07377981","phase":"PHASE4","title":"An Exploratory Study of the Efficacy and Safety of Esketamine and Dexmedetomidine in Non-Intubated ICU Patients With Hyperactive Delirium","status":"NOT_YET_RECRUITING","sponsor":"The First Affiliated Hospital with Nanjing Medical University","startDate":"2026-02-22","conditions":"Dexmedetomidine, Ketamine, Analgesia","enrollment":86},{"nctId":"NCT07059429","phase":"NA","title":"Ketamine Administration for Postoperative Pain Management in Patients Undergoing Knee Arthroplasty","status":"COMPLETED","sponsor":"State Budgetary Healthcare Institution, National Medical Surgical Center N.A. N.I. Pirogov, Ministry of Health of Russia","startDate":"2025-07-01","conditions":"Knee Arthroplasty, Postoperative Pain, Pain Management","enrollment":100},{"nctId":"NCT07427446","phase":"PHASE4","title":"Dexmedetomidine-Midazolam vs. Ketamine-Midazolam on Emergence Delirium","status":"RECRUITING","sponsor":"Kasr El Aini Hospital","startDate":"2026-02-01","conditions":"Emergence Delirium","enrollment":50},{"nctId":"NCT07422519","phase":"NA","title":"Virtual Reality-Based Mindfulness as an Adjunct to Treatment as Usual in Treatment-Resistant Depression","status":"RECRUITING","sponsor":"Hospital Universitari Vall d'Hebron Research Institute","startDate":"2025-09-18","conditions":"Depression - Major Depressive Disorder, Depression Disorder, Depression Chronic","enrollment":30},{"nctId":"NCT07138781","phase":"NA","title":"Ketamine as an Adjuvant in External Oblique Intercostal Plane Block for Post Thoracotomy Pain","status":"COMPLETED","sponsor":"Tanta University","startDate":"2025-08-23","conditions":"Ketamine, Adjuvant, External Oblique Intercostal Plane Block","enrollment":50},{"nctId":"NCT06624878","phase":"NA","title":"Esketamine for Prevention of Depression After Cytoreductive Surgery in Ovarian Cancer","status":"COMPLETED","sponsor":"Zhejiang Cancer Hospital","startDate":"2024-10-08","conditions":"Ovarian Cancer, Cytoreductive Surgery, Depressive Symptom","enrollment":568},{"nctId":"NCT07435493","phase":"NA","title":"Fentanyl Versus Opioid Free Multimodal Analgesia for Perioperative Pain Control in Children With Mild to Moderate Obstructive Sleep Apnea","status":"NOT_YET_RECRUITING","sponsor":"Ain Shams University","startDate":"2026-11-30","conditions":"Adenotonsillectomy, Obstructive Sleep Apnea (OSA), Fentanyl","enrollment":64},{"nctId":"NCT07337135","phase":"NA","title":"Opioid-Free vs Opioid-Based Anesthesia in Bariatric Surgery","status":"COMPLETED","sponsor":"Hospital dos Lusíadas","startDate":"2023-10-02","conditions":"Morbid Obesity, Postoperative Pain, Opioid Free Anesthesia","enrollment":60},{"nctId":"NCT05991232","phase":"PHASE1, PHASE2","title":"Repeated Neurocognitive Measurements in Depressed Patients","status":"WITHDRAWN","sponsor":"Jay Fournier","startDate":"2025-05-01","conditions":"Depression, Unipolar","enrollment":""},{"nctId":"NCT07433231","phase":"NA","title":"Magnesium Sulfate Versus Other Anesthesia Drugs to Reduce Agitation After Adenotonsillectomy in Pediatric Patients","status":"COMPLETED","sponsor":"Ayfer Kaya Gök","startDate":"2023-11-01","conditions":"Anesthesia Emergence Delirium, Adenotonsillar Hypertrophy","enrollment":100},{"nctId":"NCT03973268","phase":"PHASE1","title":"Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major Depression","status":"RECRUITING","sponsor":"National Institute of Mental Health (NIMH)","startDate":"2020-01-21","conditions":"Depression, Major Depressive Disorder, Major Depression","enrollment":70},{"nctId":"NCT07429916","phase":"EARLY_PHASE1","title":"Ketamine for Shoulder Pain Following Laparoscopic Gastric Sleeve Surgery","status":"RECRUITING","sponsor":"King Abdullah University Hospital","startDate":"2026-01-01","conditions":"Pain Management, Laparascopic Sleeve Gastrectomy","enrollment":50},{"nctId":"NCT07040163","phase":"EARLY_PHASE1","title":"Evaluation of Ketamine/Midazolam Sedation vs. Fentanyl/Midazolam Sedation for Image-Guided Percutaneous Procedures in Interventional Radiology","status":"ACTIVE_NOT_RECRUITING","sponsor":"CAMC Health System","startDate":"2025-03-07","conditions":"Sedation, Interventional Radiology, Biopsy","enrollment":276},{"nctId":"NCT06772753","phase":"PHASE1","title":"Investigation of Psychedelic Effects in Psychoactive Substances","status":"RECRUITING","sponsor":"Johns Hopkins University","startDate":"2025-02-05","conditions":"Psychedelic Effects in Healthy Volunteers","enrollment":50},{"nctId":"NCT07423676","phase":"","title":"Comparison Between Two Drugs in Sedation of Upper GI Endoscopy","status":"NOT_YET_RECRUITING","sponsor":"Zagazig University","startDate":"2026-03-01","conditions":"Sedation During GI Endoscopy","enrollment":52},{"nctId":"NCT07211399","phase":"EARLY_PHASE1","title":"Transition From Acute to Chronic Opioid Use and Chronic Pain","status":"NOT_YET_RECRUITING","sponsor":"Jacques E. Chelly","startDate":"2026-03-01","conditions":"Opioid Use Disorder","enrollment":700},{"nctId":"NCT07408193","phase":"EARLY_PHASE1","title":"The Role of Coadministration of Lidocaine and Ketamine in Opioid-Refractory Chronic Cancer-Related Pain.","status":"NOT_YET_RECRUITING","sponsor":"National and Kapodistrian University of Athens","startDate":"2026-03","conditions":"Opioid-Refractory Chronic Cancer-Related Pain","enrollment":24},{"nctId":"NCT07197684","phase":"NA","title":"Ultrasound Guided Pecs Block and Ketamine Infusion for Preventing Chronic Pain in Patients Undergoing Breast Cancer Surgery","status":"NOT_YET_RECRUITING","sponsor":"Aga Khan University","startDate":"2026-03-16","conditions":"Breast Cancer, Pain, Chronic, Post Surgical Pain","enrollment":120},{"nctId":"NCT07222007","phase":"","title":"Induction Agent Choice With Early Mortality and Prognostic Outcomes in Critically Ill Patients","status":"RECRUITING","sponsor":"Zeliha Alicikus","startDate":"2026-02-18","conditions":"Critically Ill, Intubation Complication, Oxygenation","enrollment":4},{"nctId":"NCT06431178","phase":"NA","title":"General Anesthesia Versus Sedation By Dexmedetomidine and Ketamine With Local Infiltration for Percutaneous Transcatheter Closure of Atrial Septal Defect in Pediatric Patients","status":"COMPLETED","sponsor":"Tanta University","startDate":"2024-05-01","conditions":"General Anesthesia, Dexmedetomidine, Ketamine","enrollment":60},{"nctId":"NCT07414706","phase":"PHASE3","title":"Intravenous Lidocaine Plus Port-Site Ropivacaine for Recovery After Laparoscopic Surgery","status":"NOT_YET_RECRUITING","sponsor":"Centre Hospitalier Universitaire, Amiens","startDate":"2026-03","conditions":"Intravenous Lidocaine, Laparoscopic Surgery, Post Operative Recovery","enrollment":182},{"nctId":"NCT06713616","phase":"PHASE3","title":"PCORI Comparative Effectiveness Study-Esketamine (Spravato) vs. Ketamine-Equivalence Study","status":"RECRUITING","sponsor":"Yale University","startDate":"2025-01-27","conditions":"Depression","enrollment":400},{"nctId":"NCT05233566","phase":"PHASE3","title":"Ketamine for Postoperative Avoidance of Depressive Symptoms: The K-PASS Feasibility Trial","status":"COMPLETED","sponsor":"Washington University School of Medicine","startDate":"2022-04-25","conditions":"Postoperative Depression","enrollment":32},{"nctId":"NCT07401914","phase":"","title":"Ketodex Versus Ketofol in Adolescent Gastrointestinal Endoscopy","status":"NOT_YET_RECRUITING","sponsor":"Giresun University","startDate":"2026-02-02","conditions":"Procedural Sedation, Gastrointestinal Endoscopy","enrollment":90},{"nctId":"NCT06559280","phase":"EARLY_PHASE1","title":"The Effect of Subclinical Dose of Ketamine on Early Postoperative Pain Sensitivity in Patients Undergoing Salpingectomy","status":"COMPLETED","sponsor":"Fujian Provincial Hospital","startDate":"2024-08-24","conditions":"Ectopic Pregnancy","enrollment":84},{"nctId":"NCT07399756","phase":"","title":"Mitochondrial Function After Ketamine","status":"NOT_YET_RECRUITING","sponsor":"Sheba Medical Center","startDate":"2026-02","conditions":"Major Depressive Disorder","enrollment":30},{"nctId":"NCT05508971","phase":"NA","title":"Treatment of Obstructive Sleep Apnea With Personalized Surgery in Children With Down Syndrome (TOPS-DS)","status":"RECRUITING","sponsor":"Oregon Health and Science University","startDate":"2023-08-02","conditions":"Obstructive Sleep Apnea, Down Syndrome","enrollment":303},{"nctId":"NCT07396220","phase":"NA","title":"Psychotherapy Combined With Intranasal Esketamine for the Treatment of Suicidal Ideation","status":"ENROLLING_BY_INVITATION","sponsor":"University of California, San Diego","startDate":"2026-01-09","conditions":"Suicidal Ideation","enrollment":56},{"nctId":"NCT03427736","phase":"","title":"Anesthetics and Analgesics in Children","status":"RECRUITING","sponsor":"Chi Dang Hornik","startDate":"2018-12-13","conditions":"Anesthesia, Pain","enrollment":460},{"nctId":"NCT05639322","phase":"PHASE4","title":"Psychotherapy for Ketamine's Enhanced Durability in Chronic Neuropathic Pain: A Randomized Controlled Pilot Trial","status":"COMPLETED","sponsor":"Unity Health Toronto","startDate":"2023-10-12","conditions":"Neuropathic Pain","enrollment":30},{"nctId":"NCT05306899","phase":"PHASE3","title":"Multi-center RCT of IV Ketamine Efficacy and Safety in Chronic Daily Headaches","status":"RECRUITING","sponsor":"University Health Network, Toronto","startDate":"2022-06-01","conditions":"Chronic Daily Headache","enrollment":56},{"nctId":"NCT03816592","phase":"","title":"Opioid Free Anaesthesia in Cardiac Surgery With Cardiopulmonary Bypass","status":"COMPLETED","sponsor":"Centre Hospitalier Universitaire Dijon","startDate":"2019-01-01","conditions":"Opioid Free Anaesthesia, Opioid Anaesthesia","enrollment":110},{"nctId":"NCT07385352","phase":"NA","title":"Caudal Dexmedetomidine vs Ketamine for Postoperative Analgesia in Pediatric DDH Surgery","status":"NOT_YET_RECRUITING","sponsor":"Assiut University","startDate":"2026-03-01","conditions":"Developmental Dysplasia of the Hip","enrollment":54},{"nctId":"NCT04833816","phase":"PHASE3","title":"Ketamine Low dOse Evaluation on Morphine Consumption in Traumatic Patient","status":"COMPLETED","sponsor":"Assistance Publique Hopitaux De Marseille","startDate":"2022-08-05","conditions":"Traumatic Injury","enrollment":140},{"nctId":"NCT04275661","phase":"PHASE2","title":"Ketamine Versus Magnesium Sulphate as Adjuvants for ESPB in Breast Cancer Surgery","status":"COMPLETED","sponsor":"Assiut University","startDate":"2020-08-01","conditions":"Analgesia, Breast Cancer","enrollment":60},{"nctId":"NCT07369089","phase":"PHASE2","title":"Targeting Treatment-Resistant OUD With Ketamine-Assisted Mindfulness Oriented Recovery Enhancement","status":"NOT_YET_RECRUITING","sponsor":"University of California, San Diego","startDate":"2026-02","conditions":"Opioid Use Disorder","enrollment":88},{"nctId":"NCT04589208","phase":"PHASE1, PHASE2","title":"Glutamatergic Mechanisms of Psychosis and Target Engagement (SA1)","status":"SUSPENDED","sponsor":"New York State Psychiatric Institute","startDate":"2021-01-01","conditions":"Healthy","enrollment":35},{"nctId":"NCT07381036","phase":"NA","title":"Comparison of Nebulized Ketamine With Nebulized Magnesium Sulfate for the Prevention of Postoperative Sore Throat","status":"NOT_YET_RECRUITING","sponsor":"Sohag University","startDate":"2026-02-01","conditions":"Postoperative Sore Throat","enrollment":150},{"nctId":"NCT06364072","phase":"PHASE2, PHASE3","title":"Safety, Tolerability, Analgesic Effect, and Feasibility of Intranasal CT001 in Pediatric Patients","status":"COMPLETED","sponsor":"Cessatech A/S","startDate":"2024-05-27","conditions":"Pain","enrollment":155},{"nctId":"NCT07380763","phase":"NA","title":"Comparison of Peri-intubation Oxygenation Values and Complications in Patients Intubated With the Delayed Versus Rapid Sequence Intubation Protocols","status":"RECRUITING","sponsor":"Kanuni Sultan Suleyman Training and Research Hospital","startDate":"2025-10-29","conditions":"Delayed Sequence Intubation, Rapid Sequence Induction and Intubation, Intubation","enrollment":140},{"nctId":"NCT05303987","phase":"PHASE2","title":"Dexmedetomidine Versus Propofol Sedation for Drug-Induced Sleep Endoscopy in Pediatric Obstructive Sleep Apnea","status":"RECRUITING","sponsor":"Erin Kirkham","startDate":"2022-10-05","conditions":"Obstructive Sleep Apnea","enrollment":90},{"nctId":"NCT05505630","phase":"EARLY_PHASE1","title":"The Effects of Sedatives on Tobacco Use Disorder Version 2","status":"COMPLETED","sponsor":"Wake Forest University Health Sciences","startDate":"2023-01-31","conditions":"Tobacco Smoking","enrollment":20},{"nctId":"NCT07374198","phase":"NA","title":"Effect of Continuous Intraoperative Esketamine Infusion on Perioperative Negative Emotions in Breast Cancer Surgery Patients With Mild-to-Severe Depression","status":"NOT_YET_RECRUITING","sponsor":"Chinese PLA General Hospital","startDate":"2026-01-18","conditions":"Depression, Anxiety, S-ketamine","enrollment":142},{"nctId":"NCT06968546","phase":"PHASE2","title":"Sufentanil Versus Ketamine Intranasally in the Management of Severe Acute Trauma-related Pain in Children.","status":"NOT_YET_RECRUITING","sponsor":"Fondation Lenval","startDate":"2026-02-05","conditions":"Traumatology, Wounds and Injury, Fractures Bone","enrollment":116},{"nctId":"NCT06795659","phase":"PHASE1, PHASE2","title":"Combining Esketamine and Prolonged Exposure Treatment for PTSD (Post Traumatic Stress Disorder)","status":"COMPLETED","sponsor":"The University of Texas Health Science Center at San Antonio","startDate":"2025-06-09","conditions":"Post Traumatic Stress Disorder PTSD","enrollment":4},{"nctId":"NCT07374458","phase":"NA","title":"Effects of Esketamine and Bilateral Lower Limb Elevation on Hemodynamic Stability During Induction of General Anesthesia in Elderly Patients Undergoing Thoracic Surgery","status":"NOT_YET_RECRUITING","sponsor":"Nanjing First Hospital, Nanjing Medical University","startDate":"2026-02-01","conditions":"Post Induction Hypotension","enrollment":292},{"nctId":"NCT07374211","phase":"NA","title":"Effect of Esketamine on Perioperative Negative Emotions in Breast Cancer Surgery Patients With Severe Depression","status":"NOT_YET_RECRUITING","sponsor":"Chinese PLA General Hospital","startDate":"2026-01-18","conditions":"Depression, Anxiety, S-ketamine","enrollment":242},{"nctId":"NCT07230171","phase":"NA","title":"The Efficacy and Safety of Short Term S-ketamine Infusion as an Adjunctive Therapy in Patients With Fibromyalgia","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2025-09-15","conditions":"Fibromyalgia, Pregabalin, Esketamine","enrollment":106},{"nctId":"NCT07367542","phase":"NA","title":"Effect of Esketamine on Perioperative Negative Emotions in Patients Undergoing Breast Cancer Surgery","status":"NOT_YET_RECRUITING","sponsor":"Chinese PLA General Hospital","startDate":"2026-01-17","conditions":"Depression, Anxiety, S-ketamine","enrollment":218},{"nctId":"NCT07369102","phase":"PHASE4","title":"Esketamine With or Without Integration Therapy for Treatment-Resistant Depression","status":"RECRUITING","sponsor":"University of Puerto Rico","startDate":"2026-02-01","conditions":"Treatment-resistant Depression (TRD)","enrollment":20},{"nctId":"NCT07370181","phase":"PHASE3","title":"Ketamine Irrigation Analgesia in Laparoscopic Cholecystectomy","status":"NOT_YET_RECRUITING","sponsor":"Assiut University","startDate":"2026-01-30","conditions":"Pain","enrollment":60},{"nctId":"NCT06419985","phase":"PHASE2","title":"Ketamine HCl Prolonged Release Oral Tablets for CRPS","status":"NOT_YET_RECRUITING","sponsor":"University of Southern California","startDate":"2026-07","conditions":"Complex Regional Pain Syndromes","enrollment":65},{"nctId":"NCT07365800","phase":"PHASE4","title":"The MDK Study: Using a Combination of Methadone-dexmedetomidine-ketamine for Postoperative Pain Control in Patients Undergoing Complex Spine Surgeries.","status":"NOT_YET_RECRUITING","sponsor":"University of Missouri-Columbia","startDate":"2026-03-02","conditions":"Spine Surgery","enrollment":248},{"nctId":"NCT06835504","phase":"PHASE3","title":"Morphine or Ketamine for Analgesia","status":"NOT_YET_RECRUITING","sponsor":"Columbia University","startDate":"2026-05-01","conditions":"Abdominal Pain, Isolated Extremity Fracture, Pain","enrollment":1010}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["ketamine hydrochloride"],"phase":"phase_3","status":"active","brandName":"IN ketamine","genericName":"IN ketamine","companyName":"London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's","companyId":"london-health-sciences-centre-research-institute-or-lawson-research-institute-of","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Intranasal ketamine is a rapid-acting NMDA receptor antagonist that blocks glutamate signaling in the brain to produce fast-onset antidepressant and analgesic effects. Used for Treatment-resistant depression, Acute suicidal ideation and behavior, Chronic pain conditions.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}