{"id":"immunonutrition-impact","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal tolerance issues"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Nausea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Impact contains a combination of immunomodulating nutrients designed to support immune competence and reduce infection risk in hospitalized patients. The formula includes L-arginine (which supports T-cell function and wound healing), fish oil-derived omega-3 fatty acids (which modulate inflammatory mediators), and RNA nucleotides (which enhance immune cell proliferation). These components work synergistically to optimize nutritional support while promoting a balanced immune response.","oneSentence":"Impact is an immunonutrition formula that provides specialized nutrients (arginine, omega-3 fatty acids, and nucleotides) to enhance immune function and reduce inflammatory response in critically ill or post-surgical patients.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:48:20.128Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Nutritional support in critically ill patients"},{"name":"Post-surgical nutritional support"},{"name":"Immune function enhancement in hospitalized patients"}]},"trialDetails":[{"nctId":"NCT06134440","phase":"NA","title":"ImmunoNutrition and Colorectal Adenocarcinoma Surgery - INCAS Study","status":"TERMINATED","sponsor":"Istituto Oncologico Veneto IRCCS","startDate":"2023-11-21","conditions":"Colorectal Adenocarcinoma","enrollment":71},{"nctId":"NCT06883422","phase":"NA","title":"Pre-Surgical Immunonutrition's Effect on Colorectal Surgery","status":"RECRUITING","sponsor":"Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran","startDate":"2023-05-25","conditions":"Colorectal Surgery","enrollment":126},{"nctId":"NCT06027515","phase":"NA","title":"Esophageal Cancer Multimodal Prehabilitation Study","status":"COMPLETED","sponsor":"Massachusetts General Hospital","startDate":"2023-12-01","conditions":"Esophageal Cancer, Esophageal Neoplasms","enrollment":15},{"nctId":"NCT07395635","phase":"NA","title":"Phase II Trial of Immunonutrition in Hepatectomy","status":"RECRUITING","sponsor":"Tata Memorial Centre","startDate":"2025-10-03","conditions":"Hepatocellular Carcinoma, ASA I-III Patients","enrollment":100},{"nctId":"NCT05069402","phase":"NA","title":"Impact of Various Diets on Surgical Complications","status":"COMPLETED","sponsor":"Stanley Dudrick's Memorial Hospital","startDate":"2021-09-01","conditions":"Complication,Postoperative","enrollment":300},{"nctId":"NCT02314182","phase":"PHASE3","title":"GRECCAR 8: Primary Tumor Resection in Rectal Cancer With Unresectable Metastasis","status":"COMPLETED","sponsor":"Hospices Civils de Lyon","startDate":"2014-11-20","conditions":"Rectal Adenocarcinoma","enrollment":5},{"nctId":"NCT05726786","phase":"PHASE3","title":"The Role of Preoperative Immunonutrition on Morbidity and Immune Response After Cystectomy (INCyst Trial)","status":"RECRUITING","sponsor":"Centre Hospitalier Universitaire Vaudois","startDate":"2023-04-10","conditions":"Bladder Cancer, Interstitial Cystitis, Painful Bladder Syndrome","enrollment":232},{"nctId":"NCT06349148","phase":"NA","title":"The Effects of Immunonutrition Therapy on Locally Advanced Cervical Cancer Patients","status":"RECRUITING","sponsor":"SHUANG ZHENG JIA, PhD","startDate":"2024-01-01","conditions":"Cervical Cancers","enrollment":50},{"nctId":"NCT00765440","phase":"PHASE3","title":"Study of Nutrition Regimens in Treating Patients With Cancer of the Upper Aerodigestive Tract","status":"COMPLETED","sponsor":"Centre Antoine Lacassagne","startDate":"2007-07","conditions":"Head and Neck Cancer, Infection, Malnutrition","enrollment":311},{"nctId":"NCT07085988","phase":"PHASE2","title":"Effect of Nutritional Management on Patients With Concurrent Chemoradiotherapy for Nasopharyngeal Carcinoma","status":"RECRUITING","sponsor":"Jiangxi Provincial Cancer Hospital","startDate":"2025-01-01","conditions":"Nasopharyngeal Carcinoma (NPC)","enrollment":109},{"nctId":"NCT07017218","phase":"NA","title":"Immunonutrition Effects on Nutrition and Immunity in HNC During Radiotherapy","status":"NOT_YET_RECRUITING","sponsor":"First Affiliated Hospital of Chongqing Medical University","startDate":"2025-06-20","conditions":"Head and Neck Cancer, Nutrition","enrollment":48},{"nctId":"NCT05384873","phase":"NA","title":"Immunonutrition for Improving the Efficacy of Immunotherapy in Patients With Metastatic Non-small Cell Lung Cancer","status":"RECRUITING","sponsor":"Fondazione IRCCS Policlinico San Matteo di Pavia","startDate":"2023-06-01","conditions":"Lung Cancer, Nonsmall Cell","enrollment":180},{"nctId":"NCT04611113","phase":"NA","title":"Immunonutrition and Tolerance to Chemoradiotherapy in Patients With Head-neck Cancer","status":"RECRUITING","sponsor":"Fondazione IRCCS Policlinico San Matteo di Pavia","startDate":"2021-03-17","conditions":"Head and Neck Cancer","enrollment":86},{"nctId":"NCT05679661","phase":"NA","title":"Perioperative Immunonutrition Intervention and Oral Decontamination in Elderly Surgical Patients","status":"RECRUITING","sponsor":"Huang YuGuang","startDate":"2023-02-06","conditions":"Postoperative Complications","enrollment":590},{"nctId":"NCT06840704","phase":"PHASE3","title":"Immunonutrition Reduces Acute Esophagitis After Thoracic Radiotherapy in Lung Cancer","status":"RECRUITING","sponsor":"Hunan Cancer Hospital","startDate":"2025-02-25","conditions":"Non Small Cell Lung Cancer, Small Cell Lung Cancer","enrollment":121},{"nctId":"NCT05061316","phase":"NA","title":"The Gut Microbiome As an Indicator of Readiness for Head & Neck Cancer Surgery","status":"COMPLETED","sponsor":"University of Alabama at Birmingham","startDate":"2022-03-11","conditions":"Cancer of Head and Neck, Nutrition Aspect of Cancer","enrollment":20},{"nctId":"NCT05971810","phase":"NA","title":"Perioperative Oral Decontamination and ImmunoNuTrition (POINT) in Elderly","status":"RECRUITING","sponsor":"Peking Union Medical College Hospital","startDate":"2023-08-23","conditions":"Postoperative Complications, Pulmonary Complication","enrollment":592},{"nctId":"NCT06736678","phase":"NA","title":"Oral Immunonutrition Therapy to Reduce Acute Toxicity After Neoadjuvant Chemoradiotherapy Pancreatic Cancer Patients","status":"RECRUITING","sponsor":"Sun Yat-sen University","startDate":"2024-08-26","conditions":"Pancreatic Cancer, Neoadjuvant Chemoradiotherapy, Immunonutrition","enrollment":98},{"nctId":"NCT04725071","phase":"NA","title":"Immunonutrition Supplementation for Improved Burn Wound Healing in Older Adults","status":"TERMINATED","sponsor":"University of Wisconsin, Madison","startDate":"2022-07-01","conditions":"Burn Wound","enrollment":11},{"nctId":"NCT05892354","phase":"NA","title":"Effect of Immunonutrients on Oral Mucositis in Nasopharyngeal Carcinoma Patients After Chemoradiotherapy","status":"RECRUITING","sponsor":"First Affiliated Hospital of Guangxi Medical University","startDate":"2023-06-12","conditions":"Locally Advanced Nasopharyngeal Carcinoma","enrollment":190},{"nctId":"NCT06355518","phase":"NA","title":"Pre-operative Immuno-Nutrition in Radical Cystectomy","status":"NOT_YET_RECRUITING","sponsor":"Fondazione IRCCS Policlinico San Matteo di Pavia","startDate":"2024-04","conditions":"Bladder Cancer","enrollment":260},{"nctId":"NCT06339372","phase":"NA","title":"Perioperative Supplementation With Immunonutrition and Its Impact on Surgical Outcome and Pain in Oral Cavity or Mandibular Tumours","status":"COMPLETED","sponsor":"Cairo University","startDate":"2023-02-01","conditions":"Immunonutrition, Surgical Outcome, Pain","enrollment":176},{"nctId":"NCT06128798","phase":"NA","title":"Effect of Preoperative Immunonutrition Versus Standard Oral Nutrition in Patient Undergoing Colorectal Surgery.","status":"UNKNOWN","sponsor":"Hospital Universiti Sains Malaysia","startDate":"2023-09-26","conditions":"Colorectal Neoplasms","enrollment":58},{"nctId":"NCT05916001","phase":"NA","title":"Preoperative Immunonutrition in Patients Undergoing Elective Colorectal Surgery for Neoplasm","status":"UNKNOWN","sponsor":"University of Roma La Sapienza","startDate":"2023-07-01","conditions":"Cancer of Colon, Nutrition Related Cancer","enrollment":216},{"nctId":"NCT05568316","phase":"NA","title":"Impact of Immunonutrition on Nutritional Status in Colorectal Cancer Patients","status":"COMPLETED","sponsor":"Saglik Bilimleri Universitesi","startDate":"2020-11-01","conditions":"Colorectal Cancer","enrollment":50},{"nctId":"NCT04469504","phase":"NA","title":"Preoperative Prehabilitation for Sarcopenic Patients Prior to Pancreatic Surgery for Cancer","status":"RECRUITING","sponsor":"University Hospital, Lille","startDate":"2022-05-17","conditions":"Sarcopenia, Pancreatic Cancer","enrollment":158},{"nctId":"NCT05526040","phase":"NA","title":"Immunonutrition Supplementation in Head and Neck Cancer Patients Undergoing Cancer Treatment Study","status":"UNKNOWN","sponsor":"University of Malaya","startDate":"2022-11-01","conditions":"Head and Neck Cancer","enrollment":116},{"nctId":"NCT03764943","phase":"PHASE3","title":"Immunonutrition and Carbohydrate Loading Strategies in Breast Reconstruction","status":"COMPLETED","sponsor":"University of Wisconsin, Madison","startDate":"2019-02-01","conditions":"Wound Complication, Wound Heal, Complications Wound","enrollment":125},{"nctId":"NCT05101889","phase":"PHASE2","title":"Benefits of Immunonutrition in Patients With Head and Neck Cancer Receiving Chemoradiation","status":"COMPLETED","sponsor":"Prince of Songkla University","startDate":"2013-01-11","conditions":"Oral Mucositis","enrollment":110},{"nctId":"NCT05068882","phase":"NA","title":"Impact of Oral Diets on Postoperative Fluid Collection","status":"UNKNOWN","sponsor":"Stanley Dudrick's Memorial Hospital","startDate":"2021-06-01","conditions":"Postoperative Complications","enrollment":400},{"nctId":"NCT04980950","phase":"NA","title":"\"The Impact of Immunonutrition on Gut Microbiota-related Aspects in Colorectal Cancer and Gastric Cancer Patients\"","status":"UNKNOWN","sponsor":"Medical University of Gdansk","startDate":"2021-08-01","conditions":"Gastric Cancer, Colorectal Cancer","enrollment":80},{"nctId":"NCT03980704","phase":"PHASE4","title":"Preoperative High Protein vs Immunodiet in Surgical Cancer Patients","status":"COMPLETED","sponsor":"Stanley Dudrick's Memorial Hospital","startDate":"2019-04-01","conditions":"General Surgery, Cancer of Colon","enrollment":299},{"nctId":"NCT02838966","phase":"NA","title":"Preoperative Nutrition With Immune Enhancing Nutritional Supplement (Immunomodulation)","status":"TERMINATED","sponsor":"University of Louisville","startDate":"2014-08","conditions":"Pancreatic Adenocarcinoma","enrollment":14},{"nctId":"NCT04732442","phase":"NA","title":"Changes in Inflammatory Response After Immunonutrition Compared to Standard Nutrition in Colorectal Cancer Tissue","status":"COMPLETED","sponsor":"Jagiellonian University","startDate":"2017-11-01","conditions":"Colon Cancer, Nutrition Aspect of Cancer","enrollment":30},{"nctId":"NCT03665714","phase":"NA","title":"Effects of Immunonutrition (Impact Oral®) in Patients Undergoing Surgery for Gastrointestinal Cancer","status":"COMPLETED","sponsor":"Société des Produits Nestlé (SPN)","startDate":"2018-10-23","conditions":"Gastrointestinal Cancer","enrollment":308},{"nctId":"NCT03628144","phase":"PHASE2","title":"Immunonutrition to Reduce Toxicities in Non-Small Cell Lung Cancer","status":"WITHDRAWN","sponsor":"H. Lee Moffitt Cancer Center and Research Institute","startDate":"2020-07","conditions":"Non Small Cell Lung Cancer, NSCLC, Non-small Cell Lung Cancer","enrollment":""},{"nctId":"NCT03333148","phase":"EARLY_PHASE1","title":"Preoperative Oral ImmunoNuTrition to Improve Surgical Outcomes for IBD Patients (PINT)","status":"WITHDRAWN","sponsor":"University of Alabama at Birmingham","startDate":"2020-06-01","conditions":"Inflammatory Bowel Diseases","enrollment":""},{"nctId":"NCT04249050","phase":"NA","title":"Effects of Immunonutrition in Patients With Pneumonia","status":"UNKNOWN","sponsor":"University of Copenhagen","startDate":"2020-03-30","conditions":"Pneumonia, Lung Infection, Muscle Loss","enrollment":40},{"nctId":"NCT01256047","phase":"PHASE4","title":"Effects of Preoperative Immunonutrition in Patients Undergoing Hepatectomy","status":"COMPLETED","sponsor":"Chiba University","startDate":"2009-05","conditions":"Bile Duct Cancer","enrollment":40},{"nctId":"NCT04014517","phase":"NA","title":"Effect of Peri-operative Immunonutrition on Recurrence and Infections in Crohn's Disease Patients","status":"UNKNOWN","sponsor":"Istituto Clinico Humanitas","startDate":"2020-03-01","conditions":"Crohn Disease","enrollment":350},{"nctId":"NCT03430128","phase":"NA","title":"Perioperative Immunonutrition for Patients Undergoing CRS and HIPEC","status":"COMPLETED","sponsor":"National Cancer Centre, Singapore","startDate":"2017-04-23","conditions":"Peritoneal Metastases","enrollment":70},{"nctId":"NCT03065348","phase":"NA","title":"Perioperative Multimodal Care for Cystectomy Frail Patient","status":"TERMINATED","sponsor":"Insel Gruppe AG, University Hospital Bern","startDate":"2017-04-06","conditions":"Frail Elderly Syndrome, Bladder Disease, Nutrition Disorders","enrollment":4},{"nctId":"NCT02647476","phase":"PHASE3","title":"Postoperative Enteral Immunonutrition in Gastric Cancer","status":"COMPLETED","sponsor":"Jagiellonian University","startDate":"2004-11","conditions":"Gastric Cancer","enrollment":98},{"nctId":"NCT02041871","phase":"NA","title":"Interest of PReOPerative Immunonutrition in Liver Surgery for Cancer","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2013-09","conditions":"Hepatectomy, Elective Hepatectomy, Malignant Tumors","enrollment":399},{"nctId":"NCT03594708","phase":"NA","title":"Immunonutrition in Ulcerative Colitis","status":"UNKNOWN","sponsor":"Baptist Memorial Health Care Corporation","startDate":"2018-04-30","conditions":"Ulcerative Colitis","enrollment":30},{"nctId":"NCT02082223","phase":"NA","title":"Individualized Preoperative Rehabilitation Pilot","status":"COMPLETED","sponsor":"Mayo Clinic","startDate":"2014-03","conditions":"Quality of Life, Complex Gastrointestinal Surgery","enrollment":20},{"nctId":"NCT01471743","phase":"NA","title":"GI Surgery Pre-Operative Nutrition","status":"COMPLETED","sponsor":"James A. Haley Veterans Administration Hospital","startDate":"2011-11","conditions":"Immunonutrition","enrollment":108},{"nctId":"NCT02580214","phase":"PHASE2, PHASE3","title":"Immunonutrition in Total Hip Arthroplasty","status":"COMPLETED","sponsor":"Federal University of Mato Grosso","startDate":"2013-05","conditions":"Arthroplasty, Hip Replacement, Perioperative Care, Nutritional Support","enrollment":32},{"nctId":"NCT02048592","phase":"PHASE4","title":"Impact of Immunonutrition on the Patients With Cystic Fibrosis","status":"UNKNOWN","sponsor":"University Hospital, Motol","startDate":"2013-09","conditions":"Cystic Fibrosis, Malnutrition, Oxidative Stress","enrollment":30},{"nctId":"NCT01789073","phase":"NA","title":"Preoperative Oral Immunonutrition for Patients With Pancreatic Cancer Undergoing Elective Surgery - Effect on Complications and Length of Hospital Stay","status":"COMPLETED","sponsor":"University of Copenhagen","startDate":"2013-02","conditions":"Pancreatic Cancer","enrollment":35},{"nctId":"NCT01969110","phase":"PHASE4","title":"Additional Effects of Perioperative Immunonutrition in Patients Undergoing Pancreaticoduodenectomy","status":"UNKNOWN","sponsor":"Chiba University","startDate":"2013-01","conditions":"Pancreatic Tumor, Bile Duct Tumor","enrollment":60},{"nctId":"NCT00560846","phase":"NA","title":"Perioperative Nutrition in Upper Gastrointestinal (GI) Cancer Surgery","status":"TERMINATED","sponsor":"Dan Azagury","startDate":"2007-11","conditions":"Stomach Neoplasms, Esophageal Neoplasms","enrollment":43},{"nctId":"NCT01256034","phase":"PHASE4","title":"Effects of Preoperative Immunonutrition in Patients Undergoing Pancreaticoduodenectomy","status":"COMPLETED","sponsor":"Chiba University","startDate":"2009-05","conditions":"Pancreatic Cancer, Bile Duct Cancer","enrollment":50},{"nctId":"NCT00333099","phase":"PHASE4","title":"INEC Study: Immuno-modulating Enteral Nutrition in Cancer","status":"COMPLETED","sponsor":"University Hospital, Clermont-Ferrand","startDate":"2006-05","conditions":"Malnutrition, Esophageal Cancer, Head and Neck Cancer","enrollment":250},{"nctId":"NCT00512213","phase":"NA","title":"Immunonutrition Versus Standard Enteral Nutrition Before Major Surgery","status":"COMPLETED","sponsor":"University of Lausanne Hospitals","startDate":"2007-09","conditions":"Major Abdominal Surgery","enrollment":154},{"nctId":"NCT00559520","phase":"PHASE4","title":"The Role of Preoperative Oral Immunonutrition in Major Vascular Surgery","status":"COMPLETED","sponsor":"Centre Hospitalier Universitaire de Nice","startDate":"2002-02","conditions":"Undernutrition","enrollment":250},{"nctId":"NCT00668876","phase":"PHASE4","title":"Effects of Immunonutrition in Patients Undergoing Pancreaticoduodenectomy","status":"COMPLETED","sponsor":"Chiba University","startDate":"2006-05","conditions":"Pancreaticoduodenectomy","enrollment":30},{"nctId":"NCT00732849","phase":"PHASE4","title":"The Impact of the Type and Route of Nutritional Support on Infectious Complications After Upper Gastrointestinal Surgery","status":"COMPLETED","sponsor":"Jagiellonian University","startDate":"2002-06","conditions":"Gastrointestinal Surgery","enrollment":600},{"nctId":"NCT00495859","phase":"NA","title":"Effects of Preoperative Long-Term Immunonutrition in Patients Listed for Liver Transplantation","status":"UNKNOWN","sponsor":"Heidelberg University","startDate":"2008-04","conditions":"Newly Registered Patients for Primary Liver Transplantation","enrollment":156},{"nctId":"NCT00558155","phase":"PHASE4","title":"The Impact of Immunostimulating Nutrition on the Outcome of Surgery","status":"COMPLETED","sponsor":"Jagiellonian University","startDate":"2001-06","conditions":"Gastric Cancer, Pancreatic Cancer","enrollment":214},{"nctId":"NCT00339053","phase":"PHASE4","title":"Immunonutrition and Thoracoabdominal Aorta Aneurysm Repair","status":"UNKNOWN","sponsor":"St. Antonius Hospital","startDate":"2004-09","conditions":"Thoracic Aortic Aneurysm, Respiratory Insufficiency","enrollment":142},{"nctId":"NCT00247793","phase":"NA","title":"Immunonutrition in Cardiac Surgery","status":"COMPLETED","sponsor":"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)","startDate":"1996-07","conditions":"Thoracic Surgery, Cardiac Surgery, Cardiopulmonary Bypass","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":318,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Immunonutrition ( Impact)","genericName":"Immunonutrition ( Impact)","companyName":"St. Antonius Hospital","companyId":"st-antonius-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Impact is an immunonutrition formula that provides specialized nutrients (arginine, omega-3 fatty acids, and nucleotides) to enhance immune function and reduce inflammatory response in critically ill or post-surgical patients. Used for Nutritional support in critically ill patients, Post-surgical nutritional support, Immune function enhancement in hospitalized patients.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}