{"id":"immediate-release-guaifenesin","safety":{"commonSideEffects":[{"rate":"10%","effect":"Nausea"},{"rate":"5%","effect":"Vomiting"},{"rate":"5%","effect":"Diarrhea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"It does this by inhibiting the action of surfactant protein A, which normally helps to reduce the surface tension of pulmonary surfactant, thereby facilitating the clearance of mucus from the airways.","oneSentence":"Guaifenesin is an expectorant that works by increasing the volume and reducing the viscosity of respiratory tract secretions.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T03:35:41.024Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute bronchitis"},{"name":"Chronic bronchitis"},{"name":"Acute upper respiratory tract infections"}]},"trialDetails":[{"nctId":"NCT03644095","phase":"PHASE1","title":"Bioequivalence Study Comparing Mucinex Extended-release 600 mg Tablets to Immediate-release Guaifenesin 600 mg in Healthy Volunteers","status":"COMPLETED","sponsor":"Reckitt Benckiser Inc.","startDate":"2009-01-16","conditions":"Healthy Subjects","enrollment":30},{"nctId":"NCT03642262","phase":"PHASE1","title":"Mucinex® ER 600 mg Bi-layer Tablet Versus Guaifenesin Immediate Release (IR) 200 mg q4h","status":"COMPLETED","sponsor":"Reckitt Benckiser Inc.","startDate":"2013-06-02","conditions":"Healthy Subjects","enrollment":30},{"nctId":"NCT03633448","phase":"PHASE1","title":"Study to Evaluate the Pharmacokinetics of Guaifenesin in Adults and Adolescents","status":"COMPLETED","sponsor":"Reckitt Benckiser LLC","startDate":"2011-06-18","conditions":"Healthy Subjects","enrollment":24},{"nctId":"NCT03643575","phase":"PHASE1","title":"Study to Characterize the Pharmacokinetics of 3 Marketed Products Containing 200 mg Guaifenesin in Healthy Volunteers.","status":"COMPLETED","sponsor":"Reckitt Benckiser Inc.","startDate":"2009-06-30","conditions":"Healthy Subjects","enrollment":30},{"nctId":"NCT02572375","phase":"PHASE1","title":"Codeine Phosphate/Guaifenesin ER Tablet 30 mg/600 mg Steady State Clinical Study","status":"COMPLETED","sponsor":"Nexgen Pharma, Inc","startDate":"2014-10","conditions":"Cough","enrollment":38},{"nctId":"NCT02157649","phase":"PHASE1","title":"Single Dose Trial of Extended Release Combination Tablet Codeine and Guaifenesin","status":"COMPLETED","sponsor":"Nexgen Pharma, Inc","startDate":"2014-06","conditions":"Cough","enrollment":26},{"nctId":"NCT01537081","phase":"PHASE2, PHASE3","title":"Safety and Efficacy of Mucinex and IR Guaifenesin the Treatment of Symptoms of Acute Upper Respiratory Tract Infections","status":"COMPLETED","sponsor":"Reckitt Benckiser LLC","startDate":"2011-09","conditions":"Acute Upper Respiratory Tract Infection","enrollment":2810},{"nctId":"NCT01062256","phase":"NA","title":"Study of Count Coughs in Subjects With Acute Upper Respiratory Tract Infections","status":"COMPLETED","sponsor":"Wyeth is now a wholly owned subsidiary of Pfizer","startDate":"2010-01","conditions":"Infection","enrollment":265}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["IR guaifenesin","IR GGE"],"phase":"phase_2","status":"active","brandName":"Immediate-release Guaifenesin","genericName":"Immediate-release Guaifenesin","companyName":"Reckitt Benckiser LLC","companyId":"reckitt-benckiser-llc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Immediate-release Guaifenesin is a small molecule with an unknown mechanism of action. It is used to treat cough and has been studied in clinical trials under various conditions, including fasted and fed states.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}