{"id":"immedate-release-torsemide-tablets","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypokalemia"},{"rate":null,"effect":"Hyperuricemia"},{"rate":null,"effect":"Ototoxicity (at high doses)"},{"rate":null,"effect":"Dehydration"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Hyperglycemia"}]},"_chembl":{"chemblId":"CHEMBL1148","moleculeType":"Small molecule","molecularWeight":"348.43"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Torsemide blocks the Na-K-2Cl cotransporter in the thick ascending limb of the loop of Henle, preventing reabsorption of sodium, potassium, and chloride. This leads to increased urine output and reduced blood volume and pressure. The immediate-release formulation provides rapid onset of diuretic action, typically within 1 hour of oral administration.","oneSentence":"Torsemide is a loop diuretic that inhibits sodium and chloride reabsorption in the ascending limb of the loop of Henle, promoting urinary excretion of water and electrolytes.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:48:12.193Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Edema associated with congestive heart failure"},{"name":"Edema associated with renal disease"},{"name":"Hypertension"}]},"trialDetails":[{"nctId":"NCT06995144","phase":"PHASE4","title":"Comparing Natriuretic Effects of ER Torsemide to IR Torsemide in Patients With Heart Failure","status":"COMPLETED","sponsor":"Sarfez Pharmaceuticals, Inc.","startDate":"2025-05-28","conditions":"Heart Failure, Edema, Pulmonary Congestion","enrollment":20}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["IR Torsemide Tablets"],"phase":"marketed","status":"active","brandName":"Immedate Release Torsemide Tablets","genericName":"Immedate Release Torsemide Tablets","companyName":"Sarfez Pharmaceuticals, Inc.","companyId":"sarfez-pharmaceuticals-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Torsemide is a loop diuretic that inhibits sodium and chloride reabsorption in the ascending limb of the loop of Henle, promoting urinary excretion of water and electrolytes. Used for Edema associated with congestive heart failure, Edema associated with renal disease, Hypertension.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}