{"id":"imipramine-pregabalin","safety":{"commonSideEffects":[{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Somnolence"},{"rate":null,"effect":"Dry mouth"},{"rate":null,"effect":"Weight gain"},{"rate":null,"effect":"Blurred vision"},{"rate":null,"effect":"Constipation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Imipramine blocks the reuptake of norepinephrine and serotonin at nerve terminals, increasing their synaptic concentrations. Pregabalin binds to the alpha-2-delta subunit of voltage-gated calcium channels, reducing calcium influx and subsequent neurotransmitter release. Together, these mechanisms address both mood and neuropathic pain pathways.","oneSentence":"This combination of a tricyclic antidepressant and a gabapentinoid works by increasing norepinephrine and serotonin availability while modulating calcium channels to reduce neuronal excitability.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:40:40.978Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Neuropathic pain with comorbid depression"},{"name":"Anxiety disorders with neuropathic pain"}]},"trialDetails":[{"nctId":"NCT04832100","phase":"","title":"Bio-significance of LPC16:0 in Fibromyalgia","status":"RECRUITING","sponsor":"Kaohsiung Medical University Chung-Ho Memorial Hospital","startDate":"2021-06-01","conditions":"Fibromyalgia, Primary, Pain, Soreness, Muscle","enrollment":245},{"nctId":"NCT04478526","phase":"NA","title":"Efficacy of Online CBT for GAD Compared to Pharmaceutical Interventions","status":"COMPLETED","sponsor":"Dr. Nazanin Alavi","startDate":"2020-04-29","conditions":"Generalized Anxiety Disorder","enrollment":115},{"nctId":"NCT02374567","phase":"PHASE3","title":"Pharmacovigilance in Gerontopsychiatric Patients","status":"TERMINATED","sponsor":"Hannover Medical School","startDate":"2015-01","conditions":"Dementia, Depression, Schizophrenia","enrollment":407},{"nctId":"NCT01047488","phase":"PHASE4","title":"Imipramine and Pregabalin Combination in Painful Polyneuropathy","status":"UNKNOWN","sponsor":"Odense University Hospital","startDate":"2010-02","conditions":"Polyneuropathy","enrollment":75}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":26,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Imipramin DAK","Lyrica"],"phase":"marketed","status":"active","brandName":"Imipramine, pregabalin","genericName":"Imipramine, pregabalin","companyName":"Odense University Hospital","companyId":"odense-university-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination of a tricyclic antidepressant and a gabapentinoid works by increasing norepinephrine and serotonin availability while modulating calcium channels to reduce neuronal excitability. Used for Neuropathic pain with comorbid depression, Anxiety disorders with neuropathic pain.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}