{"id":"im-epinephrine-1-1000","safety":{"commonSideEffects":[{"rate":null,"effect":"Tachycardia"},{"rate":null,"effect":"Hypertension"},{"rate":null,"effect":"Tremor"},{"rate":null,"effect":"Anxiety or nervousness"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Palpitations"},{"rate":null,"effect":"Arrhythmias (in susceptible patients)"}]},"_chembl":{"chemblId":"CHEMBL1256958","moleculeType":"Small molecule","molecularWeight":"333.29"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Epinephrine binds to alpha-1, alpha-2, beta-1, and beta-2 adrenergic receptors throughout the body. This activation increases cardiac output and peripheral vasoconstriction (alpha effects), relaxes bronchial smooth muscle (beta-2 effects), and inhibits mast cell degranulation and mediator release. The 1:1000 concentration (1 mg/mL) is the standard intramuscular formulation used for acute anaphylaxis.","oneSentence":"Epinephrine is a catecholamine that activates alpha and beta adrenergic receptors to increase heart rate, blood pressure, and bronchial dilation while suppressing immune mediator release.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:48:05.675Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Anaphylaxis (acute allergic reaction)"},{"name":"Severe angioedema"},{"name":"Acute bronchospasm"}]},"trialDetails":[{"nctId":"NCT01705964","phase":"PHASE4","title":"Intramuscular Epinephrine as an Adjunctive Treatment for Severe Pediatric Asthma Exacerbation","status":"COMPLETED","sponsor":"University of Louisville","startDate":"2013-06","conditions":"Asthma","enrollment":49}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":4,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"IM epinephrine 1:1000","genericName":"IM epinephrine 1:1000","companyName":"University of Louisville","companyId":"university-of-louisville","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Epinephrine is a catecholamine that activates alpha and beta adrenergic receptors to increase heart rate, blood pressure, and bronchial dilation while suppressing immune mediator release. Used for Anaphylaxis (acute allergic reaction), Severe angioedema, Acute bronchospasm.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}