{"id":"iloprost-nebuliser-solution","safety":{"commonSideEffects":[{"rate":"30-50%","effect":"Headache"},{"rate":"20-30%","effect":"Dizziness"},{"rate":"10-20%","effect":"Nausea"},{"rate":"10-20%","effect":"Flushing"},{"rate":"5-10%","effect":"Palpitations"}]},"_chembl":{"chemblId":"CHEMBL5315118","moleculeType":"Small molecule","molecularWeight":"481.63"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Iloprost works by binding to and activating the prostacyclin receptor, leading to relaxation of vascular smooth muscle and inhibition of platelet aggregation. This results in vasodilation and improved blood flow to the lungs, which is beneficial for patients with pulmonary arterial hypertension.","oneSentence":"Iloprost is a prostacyclin analogue that acts as a vasodilator and inhibits platelet aggregation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:15:32.706Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Pulmonary arterial hypertension"}]},"trialDetails":[{"nctId":"NCT04598191","phase":"NA","title":"Effect of Intraoperative Iloprost Inhalant on Hemodynamic Stability in Patients Undergoing Off-pump Coronary Artery Bypass Graft Surgery","status":"UNKNOWN","sponsor":"Yonsei University","startDate":"2020-11-04","conditions":"Coronary Artery Occlusive Disease","enrollment":100},{"nctId":"NCT02482402","phase":"PHASE2","title":"Iloprost for Bridging to Heart Transplantation in PH","status":"WITHDRAWN","sponsor":"Heidelberg University","startDate":"2015-02","conditions":"Chronic Left Ventricular Failure, Pulmonary Hypertension","enrollment":""},{"nctId":"NCT02032836","phase":"PHASE1, PHASE2","title":"Comparative PK PD Study in PAH Patients (Fox vs. I-Neb)","status":"COMPLETED","sponsor":"Bayer","startDate":"2014-03-10","conditions":"Pulmonary Arterial Hypertension","enrollment":27},{"nctId":"NCT02826252","phase":"","title":"Examination of Ventavis (Iloprost) Inhalation Behavior Using the I-Neb AAD System in Patients With Pulmonary Arterial Hypertension When Switching the Iloprost Nebulizer Solution for Inhalation From 10 μg/mL (V10) to 20 μg/mL (V20)","status":"COMPLETED","sponsor":"Bayer","startDate":"2016-09-15","conditions":"Hypertension, Pulmonary","enrollment":64},{"nctId":"NCT01598441","phase":"PHASE3","title":"Multicenter Study of Iloprost Inhaled in Pulmonary Hypertension After Repair of Congenital Heart Diseases (CHD)","status":"COMPLETED","sponsor":"Shanghai Jiao Tong University School of Medicine","startDate":"2012-06","conditions":"Pulmonary Hypertension","enrollment":8},{"nctId":"NCT00741819","phase":"PHASE4","title":"Safety Evaluation of Inhaled Treprostinil Administration Following Transition From Inhaled Ventavis in Pulmonary Arterial Hypertension (PAH) Subjects","status":"COMPLETED","sponsor":"United Therapeutics","startDate":"2008-09","conditions":"Pulmonary Arterial Hypertension","enrollment":73},{"nctId":"NCT01320878","phase":"PHASE2","title":"Study of Inhaled Iloprost for the Treatment of Pulmonary Hypertension After Repair of Congenital Heart Disease","status":"COMPLETED","sponsor":"Shanghai Jiao Tong University School of Medicine","startDate":"2007-10","conditions":"Pulmonary Hypertension","enrollment":64}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Ventavis"],"phase":"phase_3","status":"active","brandName":"iloprost nebuliser solution","genericName":"iloprost nebuliser solution","companyName":"Shanghai Jiao Tong University School of Medicine","companyId":"shanghai-jiao-tong-university-school-of-medicine","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Iloprost is a prostacyclin analogue that acts as a vasodilator and inhibits platelet aggregation. Used for Pulmonary arterial hypertension.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}