{"id":"ileocolonic-release-peppermint-oil","safety":{"commonSideEffects":[{"rate":null,"effect":"Heartburn or reflux"},{"rate":null,"effect":"Perianal burning"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Abdominal discomfort"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Peppermint oil contains menthol and other volatile compounds that act as calcium channel antagonists and smooth muscle relaxants. The ileocolonic release formulation uses enteric coating to protect the oil from gastric degradation, ensuring targeted delivery to the distal small intestine and colon where it can reduce visceral pain, bloating, and abnormal motility associated with functional bowel disorders.","oneSentence":"Ileocolonic release peppermint oil delivers peppermint oil directly to the ileum and colon, where it exerts antispasmodic and anti-inflammatory effects on the lower gastrointestinal tract.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:15:36.179Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Irritable bowel syndrome (IBS) with abdominal pain and cramping"},{"name":"Functional bowel disorder symptoms"}]},"trialDetails":[{"nctId":"NCT02716285","phase":"PHASE3","title":"Peppermint Oil for the Treatment of Irritable Bowel Syndrome: Optimizing Therapeutic Strategies Using Targeted Delivery","status":"COMPLETED","sponsor":"Maastricht University Medical Center","startDate":"2016-08-17","conditions":"Irritable Bowel Syndrome, Abdominal Pain, Colonic Diseases, Functional","enrollment":190}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Ileocolonic release peppermint oil","genericName":"Ileocolonic release peppermint oil","companyName":"Maastricht University Medical Center","companyId":"maastricht-university-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ileocolonic release peppermint oil delivers peppermint oil directly to the ileum and colon, where it exerts antispasmodic and anti-inflammatory effects on the lower gastrointestinal tract. Used for Irritable bowel syndrome (IBS) with abdominal pain and cramping, Functional bowel disorder symptoms.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}