{"id":"igm-rich-immunoglobin","safety":{"commonSideEffects":[{"rate":null,"effect":"Infusion reactions (fever, chills, flushing)"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Myalgia"},{"rate":null,"effect":"Thrombotic events"},{"rate":null,"effect":"Renal dysfunction"}]},"_chembl":{"chemblId":"CHEMBL6068090","moleculeType":"Antibody"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"IgM is the first antibody produced during primary immune responses and is highly effective at activating the classical complement pathway. IgM-rich immunoglobulin preparations deliver exogenous IgM to boost innate immune defenses, particularly useful in immunocompromised patients or those with severe infections. This enhances pathogen neutralization and clearance through complement-mediated and antibody-dependent cellular mechanisms.","oneSentence":"IgM-rich immunoglobulin provides passive immune support by supplying IgM antibodies to enhance complement activation and opsonization of pathogens.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:48:03.763Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Immunoglobulin M deficiency"},{"name":"Sepsis and severe infections in immunocompromised patients"},{"name":"Post-operative infection prophylaxis"}]},"trialDetails":[{"nctId":"NCT03403530","phase":"PHASE4","title":"Efficacy of IgM Rich Immunoglobulin With Antibiotics for Bacterial Sepsis in Very Low Birth Weight Preterm Neonates","status":"COMPLETED","sponsor":"Sir Takhtasinhji General Hospital","startDate":"2018-01-30","conditions":"Neonatal SEPSIS, Very Low Birth Weight Baby","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Pentaglobin®"],"phase":"marketed","status":"active","brandName":"IgM rich Immunoglobin","genericName":"IgM rich Immunoglobin","companyName":"Sir Takhtasinhji General Hospital","companyId":"sir-takhtasinhji-general-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"IgM-rich immunoglobulin provides passive immune support by supplying IgM antibodies to enhance complement activation and opsonization of pathogens. Used for Immunoglobulin M deficiency, Sepsis and severe infections in immunocompromised patients, Post-operative infection prophylaxis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}