{"id":"idp-123-vehicle-lotion","safety":{"commonSideEffects":[{"rate":null,"effect":"Application site irritation"},{"rate":null,"effect":"Application site erythema"}]},"_chembl":{"chemblId":"CHEMBL2108661","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"IDP-123 Vehicle Lotion is a pharmaceutical delivery system (excipient/vehicle formulation) rather than an active drug itself. It is engineered to enhance percutaneous absorption and bioavailability of incorporated active ingredients through optimized emulsion chemistry and skin penetration enhancement. The vehicle formulation facilitates consistent drug delivery across the stratum corneum and viable epidermis.","oneSentence":"IDP-123 is a topical lotion vehicle formulation designed to deliver active pharmaceutical ingredients through the skin for localized or systemic therapeutic effect.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:15:27.955Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Vehicle formulation for topical dermatological applications (specific indication dependent on active ingredient)"}]},"trialDetails":[{"nctId":"NCT03168321","phase":"PHASE3","title":"A Phase 3, Vehicle-controlled Efficacy and Safety Study of IDP-123 Lotion in the Treatment of Acne Vulgaris (301)","status":"COMPLETED","sponsor":"Bausch Health Americas, Inc.","startDate":"2017-06-29","conditions":"Acne Vulgaris","enrollment":813},{"nctId":"NCT03168334","phase":"PHASE3","title":"A Phase 3, Vehicle-controlled Efficacy and Safety Study of IDP-123 Lotion in the Treatment of Acne Vulgaris (302)","status":"COMPLETED","sponsor":"Bausch Health Americas, Inc.","startDate":"2017-07-11","conditions":"Acne Vulgaris","enrollment":801},{"nctId":"NCT02938494","phase":"PHASE2","title":"Safety and Efficacy of IDP-123 Lotion to Tazorac® Cream, in the Treatment of Acne Vulgaris","status":"COMPLETED","sponsor":"Bausch Health Americas, Inc.","startDate":"2015-11","conditions":"Acne Vulgaris","enrollment":210},{"nctId":"NCT02525822","phase":"PHASE2","title":"Study to Compare the Safety and Efficacy of IDP-123 Lotion to Tazorac Cream in the Treatment of Acne Vulgaris","status":"UNKNOWN","sponsor":"Valeant Pharmaceuticals","startDate":"2015-09","conditions":"Acne Vulgaris","enrollment":210}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":30,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Vehicle"],"phase":"phase_3","status":"active","brandName":"IDP-123 Vehicle Lotion","genericName":"IDP-123 Vehicle Lotion","companyName":"Bausch Health Americas, Inc.","companyId":"bausch-health-americas-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"IDP-123 is a topical lotion vehicle formulation designed to deliver active pharmaceutical ingredients through the skin for localized or systemic therapeutic effect. Used for Vehicle formulation for topical dermatological applications (specific indication dependent on active ingredient).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":2,"withResults":2},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}