{"id":"idp-121-lotion","safety":{"commonSideEffects":[{"rate":null,"effect":"Application site reactions"},{"rate":null,"effect":"Pruritus"},{"rate":null,"effect":"Skin irritation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"IDP 121 is a calcineurin inhibitor-based topical therapy that works by suppressing T-cell activation and reducing inflammatory cytokine production in the epidermis and dermis. The lotion formulation allows for non-systemic delivery to affected skin areas, minimizing systemic exposure while providing localized anti-inflammatory effects.","oneSentence":"IDP 121 is a topical lotion formulation designed to treat inflammatory skin conditions by reducing inflammation and modulating immune response in the skin.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:15:32.143Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Atopic dermatitis"},{"name":"Other inflammatory skin conditions"}]},"trialDetails":[{"nctId":"NCT02965456","phase":"PHASE3","title":"Efficacy and Safety of IDP-121 and IDP-121 Vehicle Lotion in the Treatment of Acne Vulgaris","status":"COMPLETED","sponsor":"Bausch Health Americas, Inc.","startDate":"2015-11-04","conditions":"Acne","enrollment":820}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"IDP 121 Lotion","genericName":"IDP 121 Lotion","companyName":"Bausch Health Americas, Inc.","companyId":"bausch-health-americas-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"IDP 121 is a topical lotion formulation designed to treat inflammatory skin conditions by reducing inflammation and modulating immune response in the skin. Used for Atopic dermatitis, Other inflammatory skin conditions.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}