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It targets thymidine kinase, a key enzyme in viral replication, to treat herpes simplex keratitis. Approved by the FDA in 1963, Dendrid is off-patent and has no active Orange Book patents, making it available from generic manufacturers. However, there are currently no generic manufacturers listed. As an off-patent drug, its commercial status is subject to change.","approvals":[{"date":"1963-06-11","orphan":false,"company":"ALLERGAN","regulator":"FDA"}],"brandName":"Dendrid","ecosystem":[{"indication":"Herpes simplex keratitis","otherDrugs":[{"name":"trifluridine","slug":"trifluridine","company":"Monarch Pharms"},{"name":"vidarabine","slug":"vidarabine","company":""}],"globalPrevalence":491500000}],"mechanism":{"target":"Thymidine kinase, cytosolic","novelty":"First-in-class","targets":[{"gene":"TK1","source":"DrugCentral","target":"Thymidine kinase, cytosolic","protein":"Thymidine kinase, cytosolic"}],"modality":"Small Molecule","drugClass":"Nucleoside Analog Antiviral","explanation":"","oneSentence":"","technicalDetail":"Dendrid (Idoxuridine) is a thymidine analog that inhibits viral DNA synthesis by competing with thymidine for incorporation into viral DNA, thereby preventing the replication of the herpes simplex 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