{"id":"idct-rebonuputemcel","safety":{"commonSideEffects":[{"rate":null,"effect":"Back pain"},{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Leg pain"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Rebonuputemcel consists of allogeneic (donor-derived) juvenile chondrocytes that are administered directly into the intervertebral disc to promote cartilage regeneration and restore disc height and function. The cells are intended to replace damaged or degenerated disc tissue and slow or reverse the progression of degenerative disc disease by restoring the structural and functional integrity of the nucleus pulposus.","oneSentence":"IDCT (rebonuputemcel) is an allogeneic juvenile chondrocyte cell therapy designed to regenerate cartilage and restore joint function in degenerative disc disease.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:48:14.004Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Degenerative disc disease of the lumbar spine"}]},"trialDetails":[{"nctId":"NCT07254806","phase":"PHASE3","title":"A Study to Evaluate the Effectiveness of IDCT (Intradiscal Cell Therapy) in Subjects With One Level, Symptomatic Mild to Moderate Lumbar Degenerative Disc Disease","status":"RECRUITING","sponsor":"DiscGenics, Inc.","startDate":"2025-12-23","conditions":"Degenerative Disc Disease","enrollment":162}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"IDCT (rebonuputemcel)","genericName":"IDCT (rebonuputemcel)","companyName":"DiscGenics, Inc.","companyId":"discgenics-inc","modality":"Biologic","firstApprovalDate":"","aiSummary":"IDCT (rebonuputemcel) is an allogeneic juvenile chondrocyte cell therapy designed to regenerate cartilage and restore joint function in degenerative disc disease. Used for Degenerative disc disease of the lumbar spine.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}