{"id":"icy-hot","safety":{"commonSideEffects":[{"rate":null,"effect":"Skin irritation or redness at application site"},{"rate":null,"effect":"Burning or stinging sensation"},{"rate":null,"effect":"Allergic contact dermatitis"}]},"_chembl":{"chemblId":"CHEMBL11268","moleculeType":"Small molecule","molecularWeight":"354.41"},"_dailymed":{"setId":"347f9a18-8ab6-47d3-9610-5b4e9ca5d53a","title":"ICY HOT LIDOCAINE NO-MESS (LIDOCAINE HYDROCHLORIDE) LIQUID [CHATTEM, INC.]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Menthol activates cold-sensitive TRPM8 receptors, creating a cooling sensation that masks pain signals, while methyl salicylate acts as a topical analgesic and anti-inflammatory agent. 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Used for Minor muscle aches and pains, Minor arthritis pain, Backache.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}