{"id":"ics-laba-and-montelukast","safety":{"commonSideEffects":[{"rate":null,"effect":"Tremor"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Palpitations"},{"rate":null,"effect":"Oral candidiasis"},{"rate":null,"effect":"Muscle pain"}]},"_chembl":{"chemblId":"CHEMBL1200681","moleculeType":"Small molecule","molecularWeight":"608.18"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The inhaled corticosteroid (ICS) component suppresses inflammatory pathways and reduces eosinophil recruitment in the airways. The long-acting beta-2 agonist (LABA) relaxes bronchial smooth muscle and provides sustained bronchodilation. Montelukast, a cysteinyl leukotriene receptor antagonist, blocks leukotriene-mediated inflammation and bronchoconstriction, providing complementary anti-inflammatory and bronchodilatory effects.","oneSentence":"This combination reduces airway inflammation and bronchoconstriction by suppressing inflammatory mediators and relaxing airway smooth muscle.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:48:02.904Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Asthma (maintenance and reliever therapy)"},{"name":"Chronic obstructive pulmonary disease (COPD) with asthmatic features"}]},"trialDetails":[{"nctId":"NCT04480242","phase":"","title":"Asthma Research in Children and Adolescents","status":"ACTIVE_NOT_RECRUITING","sponsor":"Parc de Salut Mar","startDate":"2017-07-26","conditions":"Persistent Asthma, Asthma in Children, Asthma Exacerbation","enrollment":525},{"nctId":"NCT04322422","phase":"NA","title":"Clinical Characteristics and Treatment of Chest Tightness Variant Asthma","status":"UNKNOWN","sponsor":"Second Affiliated Hospital, School of Medicine, Zhejiang University","startDate":"2020-06-01","conditions":"Asthma, Chest Syndrome, Clinical Anxiety","enrollment":300},{"nctId":"NCT01725360","phase":"PHASE4","title":"Change of Airway Hyperresponsiveness to Mannitol and Methacholine in Patients With Asthma","status":"COMPLETED","sponsor":"Cantonal Hosptal, Baselland","startDate":"2007-01","conditions":"Asthma","enrollment":17},{"nctId":"NCT01404013","phase":"PHASE4","title":"Effects of Leukotriene Modulator Montelukast on Cough Variant Asthma","status":"UNKNOWN","sponsor":"The First Affiliated Hospital of Guangzhou Medical University","startDate":"2012-02","conditions":"Asthma","enrollment":99},{"nctId":"NCT00699062","phase":"PHASE4","title":"Effect of Montelukast on the Airway Remodeling","status":"COMPLETED","sponsor":"Chinese Academy of Medical Sciences","startDate":"2010-01","conditions":"Asthma","enrollment":40}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Inhaled corticosteroid/β2 agonist: Symbicort Turbuhaler","Montelukast: Singulair"],"phase":"marketed","status":"active","brandName":"ICS/LABA and Montelukast","genericName":"ICS/LABA and Montelukast","companyName":"The First Affiliated Hospital of Guangzhou Medical University","companyId":"the-first-affiliated-hospital-of-guangzhou-medical-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination reduces airway inflammation and bronchoconstriction by suppressing inflammatory mediators and relaxing airway smooth muscle. Used for Asthma (maintenance and reliever therapy), Chronic obstructive pulmonary disease (COPD) with asthmatic features.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}