{"id":"ici35-868-diprivan","safety":{"commonSideEffects":[{"rate":"26","effect":"Hypotension"},{"rate":"12","effect":"Apnea"},{"rate":"12","effect":"Bradycardia"},{"rate":"18","effect":"Injection site pain"},{"rate":"3","effect":"Hypertension"},{"rate":"2","effect":"Tachycardia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Propofol potentiates the effect of the inhibitory neurotransmitter GABA by binding to GABA-A receptors, leading to hyperpolarization of neuronal membranes and rapid onset of sedation and unconsciousness. It is commonly used for induction and maintenance of general anesthesia, as well as for sedation in intensive care settings.","oneSentence":"Propofol is a rapid-acting intravenous sedative-hypnotic agent that enhances inhibitory GABAergic neurotransmission in the central nervous system.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:42:05.235Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Induction of general anesthesia"},{"name":"Maintenance of general anesthesia"},{"name":"Sedation in mechanically ventilated patients in intensive care units"}]},"trialDetails":[],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":359,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"ICI35,868 (Diprivan)","genericName":"ICI35,868 (Diprivan)","companyName":"AstraZeneca","companyId":"astrazeneca","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Propofol is a rapid-acting intravenous sedative-hypnotic agent that enhances inhibitory GABAergic neurotransmission in the central nervous system. Used for Induction of general anesthesia, Maintenance of general anesthesia, Sedation in mechanically ventilated patients in intensive care units.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}