{"id":"icg-r15","safety":{"commonSideEffects":[{"rate":null,"effect":"Allergic reactions (rare)"},{"rate":null,"effect":"Transient hypotension"},{"rate":null,"effect":"Flushing"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"ICG R15 is a modified indocyanine green contrast agent that binds to plasma proteins and is rapidly taken up and excreted by hepatocytes. The near-infrared fluorescence allows surgeons to visualize liver perfusion, assess hepatic function intraoperatively, and identify areas of compromised blood supply in real time, enabling safer hepatic resection.","oneSentence":"ICG R15 is an indocyanine green (ICG) derivative that fluoresces in the near-infrared spectrum for real-time visualization of liver function and blood flow during surgery.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:40:38.000Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Intraoperative assessment of liver function and perfusion during hepatic surgery"},{"name":"Real-time visualization of hepatic blood flow and viability during liver resection"}]},"trialDetails":[{"nctId":"NCT05986383","phase":"","title":"Multi-center Clinical Study on the Decision Tree of Precision Hepatectomy in China Precision Hepatectomy Decision Tree","status":"UNKNOWN","sponsor":"Beijing Tsinghua Chang Gung Hospital","startDate":"2023-08","conditions":"Primary Liver Cancer, Metastatic Liver Cancer, Benign Liver Neoplasms","enrollment":820},{"nctId":"NCT05800561","phase":"","title":"Prognostic Role of HVPG and ICG-R15 in the Short- and Medium-term Results of the Surgery of HCC on Cirrhosis","status":"UNKNOWN","sponsor":"Federico II University","startDate":"2022-01-01","conditions":"Hepatocellular Carcinoma","enrollment":208},{"nctId":"NCT03295500","phase":"","title":"On the Cyberknife Dose Fraction of Liver Cancer Treatment","status":"COMPLETED","sponsor":"Beijing 302 Hospital","startDate":"2017-11-01","conditions":"CyberKnife Radiosurgery","enrollment":657},{"nctId":"NCT00827723","phase":"","title":"Indocyanine Green and Portal Pressure in Viral and Alcoholic Cirrhotic Patients With Hepatocarcinoma","status":"COMPLETED","sponsor":"University of Lausanne Hospitals","startDate":"2009-02","conditions":"Carcinoma, Hepatocellular, Alcoholic Cirrhosis, Viral Cirrhosis","enrollment":60},{"nctId":"NCT02854371","phase":"PHASE4","title":"Evaluation of Hepatic Function Using Gadoxetic Acid Enhanced MRI","status":"COMPLETED","sponsor":"Seoul National University Hospital","startDate":"2016-08","conditions":"Cirrhosis","enrollment":54},{"nctId":"NCT01490203","phase":"","title":"Evaluation of Remnant Liver Function Using Primovist-enhanced MRI Before Resection/Ablation of Hepatocellular Carcinoma","status":"COMPLETED","sponsor":"Seoul National University Hospital","startDate":"2011-12","conditions":"Carcinoma, Hepatocellular, Liver Dysfunction","enrollment":71},{"nctId":"NCT02552901","phase":"PHASE3","title":"Cardiox Liver Function Test Pivotal Trial","status":"WITHDRAWN","sponsor":"Cardiox Corporation","startDate":"2015-11","conditions":"Hepatic Failure, Liver Failure","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Indocyanine green retention test"],"phase":"marketed","status":"active","brandName":"ICG R15","genericName":"ICG R15","companyName":"Seoul National University Hospital","companyId":"seoul-national-university-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"ICG R15 is an indocyanine green (ICG) derivative that fluoresces in the near-infrared spectrum for real-time visualization of liver function and blood flow during surgery. Used for Intraoperative assessment of liver function and perfusion during hepatic surgery, Real-time visualization of hepatic blood flow and viability during liver resection.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}