{"id":"ibuprofen-suppository","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal irritation"},{"rate":null,"effect":"Rectal irritation or discomfort"},{"rate":null,"effect":"Dyspepsia"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Headache"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that blocks COX-1 and COX-2 enzymes, which are responsible for producing prostaglandins that mediate inflammatory responses, pain signaling, and fever regulation. The suppository formulation delivers ibuprofen rectally for systemic absorption, providing an alternative route to oral administration, particularly useful in patients unable to take oral medications or requiring rapid onset of action.","oneSentence":"Ibuprofen inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation, pain, and fever.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:33:15.655Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Fever reduction"},{"name":"Mild to moderate pain"},{"name":"Inflammation"}]},"trialDetails":[{"nctId":"NCT05878262","phase":"NA","title":"The Effect of Pre-emptive Analgesia on the Postoperative Pain in Children Undergoing Pediatric Stomatology Day Surgeries","status":"COMPLETED","sponsor":"The Children's Hospital of Zhejiang University School of Medicine","startDate":"2022-09-01","conditions":"Ankyloglossia, Oral Mucoceles, Supernumerary Teeth","enrollment":120},{"nctId":"NCT04869046","phase":"PHASE4","title":"Levobupivacaine and Postoperative Pain Relief","status":"COMPLETED","sponsor":"Mother and Child Health Institute of Serbia Dr Vukan Cupic","startDate":"2013-03","conditions":"Postoperative Pain, Inguinal Hernia Unilateral","enrollment":100},{"nctId":"NCT04227652","phase":"NA","title":"Control of Fever in Septic Patients","status":"COMPLETED","sponsor":"University Hospital Ostrava","startDate":"2013-09-03","conditions":"Sepsis, Severe Sepsis, Septic Shock","enrollment":140},{"nctId":"NCT00921830","phase":"PHASE1","title":"Pharmacokinetics of 3 Formulations of Ibuprofen Suppositories","status":"COMPLETED","sponsor":"Johnson & Johnson Consumer and Personal Products Worldwide","startDate":"2004-04","conditions":"Healthy","enrollment":25},{"nctId":"NCT00729976","phase":"PHASE4","title":"Oral Versus Rectal Ibuprofen for Fever in Young Children - a Randomized Control Study.","status":"UNKNOWN","sponsor":"Assaf-Harofeh Medical Center","startDate":"2008-09","conditions":"Fever","enrollment":40},{"nctId":"NCT00938509","phase":"PHASE4","title":"Ibuprofen Suppositories Administration in Infants and Children","status":"UNKNOWN","sponsor":"Soroka University Medical Center","startDate":"2009-07","conditions":"Fever","enrollment":100},{"nctId":"NCT00568217","phase":"PHASE4","title":"Antipyretics for Preventing Recurrences of Febrile Seizures","status":"COMPLETED","sponsor":"University of Oulu","startDate":"1997-09","conditions":"Recurrence of Febrile Seizure","enrollment":231}],"_emaApprovals":[],"_faersSignals":[{"count":1,"reaction":"BRONCHIOLITIS"},{"count":1,"reaction":"KAWASAKI^S DISEASE"},{"count":1,"reaction":"RESPIRATORY TRACT INFECTION"},{"count":1,"reaction":"SEPSIS"}],"_approvalHistory":[],"publicationCount":6,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["no medicine"],"phase":"marketed","status":"active","brandName":"Ibuprofen suppository","genericName":"Ibuprofen suppository","companyName":"Assaf-Harofeh Medical Center","companyId":"assaf-harofeh-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ibuprofen inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation, pain, and fever. Used for Fever reduction, Mild to moderate pain, Inflammation.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}