{"id":"ibuprofen-piconol","rwe":[{"pmid":"8902502","year":"1996","title":"Spontaneous comedones on the skin of hairless descendants of Mexican hairless dogs.","finding":"","journal":"Experimental animals","studyType":"Clinical Study"},{"pmid":"2013845","year":"1991","title":"Ibuprofen piconol hydrolysis in vitro in plasma, whole blood, and serum using different anticoagulants.","finding":"","journal":"Journal of pharmaceutical sciences","studyType":"Clinical Study"},{"pmid":"3365979","year":"1988","title":"Contact dermatitis from ibuprofen piconol.","finding":"","journal":"Contact dermatitis","studyType":"Clinical Study"}],"tags":[{"label":"Nonsteroidal Anti-inflammatory Drug","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Analgesics","category":"pharmacology"},{"label":"Analgesics, Non-Narcotic","category":"pharmacology"},{"label":"Anti-Inflammatory Agents","category":"pharmacology"},{"label":"Anti-Inflammatory Agents, Non-Steroidal","category":"pharmacology"},{"label":"Antirheumatic Agents","category":"pharmacology"},{"label":"Central Nervous System Agents","category":"pharmacology"},{"label":"Cyclooxygenase Inhibitors","category":"pharmacology"},{"label":"Enzyme Inhibitors","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Sensory System Agents","category":"pharmacology"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"staderm","offLabel":[],"synonyms":["ibuprofen piconol","pimeprofen","staderm"],"timeline":[],"approvals":[],"brandName":"Staderm","ecosystem":[],"mechanism":{"moaClass":"Cyclooxygenase Inhibitors","modality":"Small Molecule","drugClass":"Nonsteroidal Anti-inflammatory Drug","explanation":"Imagine your body's pain and inflammation response like a fire. Prostaglandins are like the fuel that keeps the fire burning. Staderm puts out the fire by blocking the production of prostaglandins, which helps to reduce pain and inflammation.","oneSentence":"Staderm works by inhibiting the enzyme cyclooxygenase (COX), which is responsible for producing prostaglandins that cause pain and inflammation.","technicalDetail":"Staderm, as a COX inhibitor, selectively blocks the activity of COX-1 and COX-2 enzymes, leading to a decrease in prostaglandin synthesis and subsequent reduction in pain and inflammation."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1409","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ibuprofen piconol","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T11:59:34.115876","biosimilars":[],"competitors":[],"genericName":"ibuprofen piconol","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"MMSL":"2133","NDDF":"002377","UNII":"B0F91K5U4N","CHEBI":"CHEBI:31685","VANDF":"4017840","INN_ID":"2118","RXNORM":"5640","UMLSCUI":"C0071068","ChEMBL_ID":"CHEMBL2106254","KEGG_DRUG":"D01122","DRUGBANK_ID":"DB16887","PDB_CHEM_ID":" IBP","PUBCHEM_CID":"3673","SNOMEDCT_US":"38268001","MESH_DESCRIPTOR_UI":"D007052","MESH_SUPPLEMENTAL_RECORD_UI":"C052308"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":3,"therapeuticAreas":["Pain"],"biosimilarFilings":[],"recentPublications":[{"date":"1996 Oct","pmid":"8902502","title":"Spontaneous comedones on the skin of hairless descendants of Mexican hairless dogs.","journal":"Experimental animals"},{"date":"1991 Jan","pmid":"2013845","title":"Ibuprofen piconol hydrolysis in vitro in plasma, whole blood, and serum using different anticoagulants.","journal":"Journal of pharmaceutical sciences"},{"date":"1988 Mar","pmid":"3365979","title":"Contact dermatitis from ibuprofen piconol.","journal":"Contact dermatitis"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Staderm, also known as ibuprofen piconol, is a nonsteroidal anti-inflammatory drug (NSAID) in the small molecule modality. It is a derivative of ibuprofen, a widely used medication for pain relief and inflammation. However, specific details about its target, FDA approval status, and commercial status are not available. As an NSAID, Staderm is likely used to treat conditions such as arthritis, menstrual cramps, and other pain-related disorders. Further research is needed to confirm its exact indications and safety profile.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}