{"id":"ibuprofen-guaiacol-ester","rwe":[{"pmid":"12168506","year":"2002","title":"Gateways to Clinical Trials. June 2002.","finding":"","journal":"Methods and findings in experimental and clinical pharmacology","studyType":"Clinical Study"},{"pmid":"6882531","year":"1983","title":"Additional pharmacological studies on ibuprofen guaiacol ester (AF 2259).","finding":"","journal":"Bollettino chimico farmaceutico","studyType":"Clinical Study"},{"pmid":"7184507","year":"1982","title":"A study of the absorption and tolerance of ibuprofen guaiacol ester in man after repeated oral administration.","finding":"","journal":"Bollettino chimico farmaceutico","studyType":"Clinical Study"},{"pmid":"7183325","year":"1982","title":"Studies on the oral absorption of ibuprofen guaiacol-ester in man.","finding":"","journal":"Bollettino chimico farmaceutico","studyType":"Clinical Study"},{"pmid":"6968463","year":"1980","title":"A toxicological and pharmacological study of ibuprofen guaiacol ester (AF 2259) in the rat.","finding":"","journal":"Toxicology and applied pharmacology","studyType":"Clinical Study"}],"tags":[{"label":"Nonsteroidal Anti-inflammatory Drug","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Analgesics","category":"pharmacology"},{"label":"Analgesics, Non-Narcotic","category":"pharmacology"},{"label":"Anti-Inflammatory Agents","category":"pharmacology"},{"label":"Anti-Inflammatory Agents, Non-Steroidal","category":"pharmacology"},{"label":"Antirheumatic Agents","category":"pharmacology"},{"label":"Central Nervous System Agents","category":"pharmacology"},{"label":"Cyclooxygenase Inhibitors","category":"pharmacology"},{"label":"Enzyme Inhibitors","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Sensory System Agents","category":"pharmacology"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"metoxibutropate","offLabel":[],"synonyms":["ibuprofen guaiacol ester","methoxybutropate","metoxibutropate"],"timeline":[],"approvals":[],"brandName":"Metoxibutropate","ecosystem":[],"mechanism":{"moaClass":"Cyclooxygenase Inhibitors","modality":"Small Molecule","drugClass":"Nonsteroidal Anti-inflammatory Drug","explanation":"Think of prostaglandins like messengers that tell your body to feel pain and become inflamed. When you take metoxibutropate, it blocks these messengers from being made, which can help reduce pain and swelling. This is similar to how other pain-relieving medications work, but metoxibutropate is a bit different because it's a special type of ibuprofen.","oneSentence":"Metoxibutropate works by blocking the production of prostaglandins, which are hormone-like substances that cause pain and inflammation.","technicalDetail":"Metoxibutropate is a prodrug that is metabolized to ibuprofen, which then inhibits the cyclooxygenase (COX) enzyme, specifically COX-1 and COX-2 isoforms, to reduce prostaglandin production and alleviate pain and inflammation."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1410","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ibuprofen guaiacol ester","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T13:54:59.802050","biosimilars":[],"competitors":[],"genericName":"ibuprofen guaiacol ester","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"MMSL":"2133","NDDF":"002377","UNII":"0N623MNK8Z","CHEBI":"CHEBI:135336","VANDF":"4017840","INN_ID":"2118","RXNORM":"5640","UMLSCUI":"C0066471","DRUGBANK_ID":"DB01050","PDB_CHEM_ID":" IBP","PUBCHEM_CID":"4464271","SNOMEDCT_US":"38268001","MESH_DESCRIPTOR_UI":"D007052","MESH_SUPPLEMENTAL_RECORD_UI":"C020176"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":5,"therapeuticAreas":["Pain"],"biosimilarFilings":[],"recentPublications":[{"date":"2002 Jun","pmid":"12168506","title":"Gateways to Clinical Trials. June 2002.","journal":"Methods and findings in experimental and clinical pharmacology"},{"date":"1983 Jan","pmid":"6882531","title":"Additional pharmacological studies on ibuprofen guaiacol ester (AF 2259).","journal":"Bollettino chimico farmaceutico"},{"date":"1982 Dec","pmid":"7184507","title":"A study of the absorption and tolerance of ibuprofen guaiacol ester in man after repeated oral administration.","journal":"Bollettino chimico farmaceutico"},{"date":"1982 Nov","pmid":"7183325","title":"Studies on the oral absorption of ibuprofen guaiacol-ester in man.","journal":"Bollettino chimico farmaceutico"},{"date":"1980 Jun 30","pmid":"6968463","title":"A toxicological and pharmacological study of ibuprofen guaiacol ester (AF 2259) in the rat.","journal":"Toxicology and applied pharmacology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Metoxibutropate, also known as ibuprofen guaiacol ester, is a nonsteroidal anti-inflammatory drug (NSAID) of the small molecule modality. Its exact target is unknown, but it is believed to work by inhibiting the enzyme cyclooxygenase (COX), which is involved in the production of prostaglandins that cause pain and inflammation. Metoxibutropate is not FDA-approved for any indications, and its commercial status is unclear. As an NSAID, it is likely to have similar safety considerations to other drugs in this class, including gastrointestinal side effects and potential interactions with other medications. Further research is needed to fully understand the properties and potential uses of metoxibutropate.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}