{"id":"ibuprofen-advil","safety":{"commonSideEffects":[{"rate":"5-15","effect":"Gastrointestinal upset (nausea, dyspepsia, abdominal pain)"},{"rate":"3-10","effect":"Heartburn"},{"rate":"1-3","effect":"Dizziness"},{"rate":"1-3","effect":"Rash"},{"rate":null,"effect":"Increased risk of cardiovascular events (with chronic use)"},{"rate":null,"effect":"Increased risk of gastrointestinal bleeding (with chronic use)"}]},"_chembl":{"chemblId":"CHEMBL521","moleculeType":"Small molecule","molecularWeight":"206.28"},"_dailymed":{"setId":"42c7dbec-2e53-70ae-e063-6294a90a16e6","title":"IBUPROFEN MINI DYE FREE ADVIL (IBUPROFEN) CAPSULE, LIQUID FILLED [CVS PHARMACY]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that non-selectively inhibits both COX-1 and COX-2 enzymes. By blocking these enzymes, it reduces prostaglandin synthesis, which are key mediators of inflammation, pain signaling, and fever regulation. This mechanism makes it effective for mild to moderate pain and inflammatory conditions.","oneSentence":"Ibuprofen inhibits cyclooxygenase (COX) enzymes to reduce the production of prostaglandins, thereby decreasing inflammation, pain, and fever.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:47:55.450Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Mild to moderate pain"},{"name":"Fever reduction"},{"name":"Inflammation associated with headache, muscular aches, backache, minor arthritis pain, menstrual cramps, and the common cold"}]},"trialDetails":[{"nctId":"NCT07498556","phase":"NA","title":"Immediate Restoration of a New Implant With High Primary Stability","status":"NOT_YET_RECRUITING","sponsor":"Universidade do Porto","startDate":"2026-03-01","conditions":"Dental Implants, Immediate Dental Implant Loading","enrollment":50},{"nctId":"NCT07493226","phase":"NA","title":"Efficacy of Chemically Distinct Nonsteroidal Anti-Inflammatory 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