{"id":"ibuprofen-acetaminophen","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Dyspepsia"},{"rate":null,"effect":"Hepatotoxicity (acetaminophen component at high doses)"},{"rate":null,"effect":"Renal impairment (ibuprofen component)"}]},"_chembl":{"chemblId":"CHEMBL1647","moleculeType":"Small molecule","molecularWeight":"327.29"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that blocks COX-1 and COX-2 enzymes, reducing production of inflammatory prostaglandins and providing analgesic, antipyretic, and anti-inflammatory effects. Acetaminophen (paracetamol) works primarily through central inhibition of prostaglandin synthesis and modulation of pain and temperature regulation pathways. The combination provides complementary analgesic and antipyretic effects with potentially improved efficacy over either agent alone.","oneSentence":"Ibuprofen inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, while acetaminophen inhibits prostaglandin synthesis and modulates pain perception centrally.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:47:51.901Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Mild to moderate pain"},{"name":"Fever reduction"},{"name":"Headache"},{"name":"Musculoskeletal pain"}]},"trialDetails":[{"nctId":"NCT07094542","phase":"PHASE2","title":"Jaw Muscle Pain Post Wisdom Molar Surgery","status":"NOT_YET_RECRUITING","sponsor":"Rutgers, The State University of New Jersey","startDate":"2026-05","conditions":"Post Operative Pain, Impacted Third Molar Tooth, Muscle Pain","enrollment":80},{"nctId":"NCT07337902","phase":"NA","title":"Comparing Over the Counter Pain Medicines for Discomfort in 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